Výsledky vyhledávání - "Bertrand Bellier"

Akademický článek

Interleukin-1 regulates follicular T cells during the germinal center reaction

Autor: Aude Belbezier, Paul Engeroff, Gwladys Fourcade, Hélène Vantomme, Romain Vaineau, Bruno Gouritin, Bertrand Bellier, Isabelle Brocheriou, Nicolas Tchitchek, Stephanie Graff-Dubois, David Klatzmann

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionAntibody production and the generation of memory B cells are regulated by T follicular helper (Tfh) and T follicular regulatory (Tfr) cells in germinal centers. However, the precise role of Tfr cells in controlling antibody production is

Externí odkaz: https://doaj.org/article/1970145b093f439fac4b1076c56464d0

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Akademický článek

A Thermostable Oral SARS-CoV-2 Vaccine Induces Mucosal and Protective Immunity

Autor: Bertrand Bellier, Alicia Saura, Lucas A. Luján, Cecilia R. Molina, Hugo D. Luján, David Klatzmann

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

An ideal protective vaccine against SARS-CoV-2 should not only be effective in preventing disease, but also in preventing virus transmission. It should also be well accepted by the population and have a simple logistic chain. To fulfill these criteri

Externí odkaz: https://doaj.org/article/358d2206ce0f4133aa9e7ac0a3412f92

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Akademický článek

Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins

Autor: Marianela C. Serradell, Lucía L. Rupil, Román A. Martino, César G. Prucca, Pedro G. Carranza, Alicia Saura, Elmer A. Fernández, Pablo R. Gargantini, Albano H. Tenaglia, Juan P. Petiti, Renata R. Tonelli, Nicolás Reinoso-Vizcaino, José Echenique, Luciana Berod, Eliane Piaggio, Bertrand Bellier, Tim Sparwasser, David Klatzmann, Hugo D. Luján

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

Giardia lamblia express a dense coat of variant-specific surface proteins (VSPs) on trophozoites that protects the parasite inside the host´s intestine. Here the authors show that stability and immunomodulatory properties of VSPs can be exploited to

Externí odkaz: https://doaj.org/article/e1faa7844c394e018f3b0bfaf2625985

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Akademický článek

Different immunogenicity but similar antitumor efficacy of two DNA vaccines coding for an antigen secreted in different membrane vesicle-associated forms

Autor: Christine Sedlik, James Vigneron, Lea Torrieri-Dramard, Fabien Pitoiset, Jordan Denizeau, Caroline Chesneau, Philippe de la Rochere, Olivier Lantz, Clotilde Thery, Bertrand Bellier

Publikováno v: Journal of Extracellular Vesicles, Vol 3, Iss 0, Pp 1-13 (2014)

The induction of an active immune response to control or eliminate tumours is still an unfulfilled challenge. We focused on plasmid DNA vaccines using an innovative approach whereby the antigen is expressed in association with extracellular vesicles

Externí odkaz: https://doaj.org/article/90ad55465d674ba9b020cc69846af4f1

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Akademický článek

Early Transcriptome Signatures from Immunized Mouse Dendritic Cells Predict Late Vaccine-Induced T-Cell Responses.

Autor: Nicolas Dérian, Bertrand Bellier, Hang Phuong Pham, Eliza Tsitoura, Dorothea Kazazi, Christophe Huret, Penelope Mavromara, David Klatzmann, Adrien Six

Publikováno v: PLoS Computational Biology, Vol 12, Iss 3, p e1004801 (2016)

Systems biology offers promising approaches for identifying response-specific signatures to vaccination and assessing their predictive value. Here, we designed a modelling strategy aiming to predict the quality of late T-cell responses after vaccinat

Externí odkaz: https://doaj.org/article/6685f8efcda44805b44c1437fdccdc9f

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Interleukin-1 regulates follicular T cells during the germinal center reaction

Autor: Aude Belbezier, Paul Engeroff, Gwladys Fourcade, Helene Vantomme, Romain Vaineau, Bruno Gouritin, Bertrand Bellier, Isabelle Brocheriou, Nicolas Tchitchek, Stephanie Graff-Dubois, David Klatzmann

Antibody production by plasma cells and generation of long-term memory B-cells are positively regulated by Tfh cells and negatively regulated by Tfr cells in germinal centers. However, the precise role of Tfr cells in controlling antibody production

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6342ac163c6bae16d86c95fd20030ea2
https://doi.org/10.1101/2023.03.29.534687

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A thermostable oral SARS-CoV-2 vaccine induces mucosal and protective immunity

Autor: Hugo D. Lujan, Cecilia Molina, Lucas Lujan, Bertrand Bellier, Alicia Saura, David Klatzmann

Publikováno v: Bellier, Bertrand, Saura, Alicia ORCID: https://orcid.org/0000-0003-1537-506X , Luján, Lucas A. ORCID: https://orcid.org/0000-0003-4235-4301 , Molina, Cecilia R., Luján, Hugo Daniel ORCID: https://orcid.org/0000-0002-3797-8315 and Klatzmann, David (2022) A Thermostable Oral SARS-CoV-2 Vaccine Induces Mucosal and Protective Immunity. Frontiers in Immunology, 13. ISSN 1664-3224

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a952a8c207cccf1f630f804032693693
https://doi.org/10.1101/2021.09.09.459634

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Regulatory T-cell development and function are impaired in mice lacking membrane expression of full length intercellular adhesion molecule-1

Autor: Bertrand Bellier, Nicolas Prevel, Gaelle Gottrand, Véronique Thomas-Vaslin, Thomas Vazquez, Tristan Courau, Bruno M. Colombo, Maria Grazia Ruocco, Bénédicte Lambrecht, David Klatzmann

Publikováno v: Immunology. 146:657-670

To further investigate the contribution of intercellular adhesion molecule-1 (ICAM-1) to adaptive immune responses, we analysed T-cell development and function in mice lacking full-length ICAM-1 (ICAM-1(tm1Jcgr) ). Compared with wild-type (ICAM-1(WT)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f22a855ab79a6b35050097c8402a698
https://doi.org/10.1111/imm.12533

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SAT0023 Direct-acting antiviral-based therapy restores immune tolerance in hepatitis c-induced cryoglobulinemia vasculitis

Autor: A-C Desbois, M. Rosenzwajg, Laurent Alric, Si Nafa Si Ahmed, Patrice Cacoub, Cloé Comarmond, David Klatzmann, Bertrand Bellier, M. Garrido, D. Saadoun, A Maciejewski, Lucile Musset, M Garff-Tavernier Le, Hélène Fontaine, Thierry Poynard, M Costopoulos

Publikováno v: Poster Presentations.

Objectives Interferon-free direct-acting antiviral (DAA)-based therapy has proven to be very effective in patients with hepatitis C virus-cryoglobulinemia vasculitis (HCV-CV). However, their mechanisms of action and their effects on cellular immunity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aff89dd4607fc181041381feadcae104
https://doi.org/10.1136/annrheumdis-2017-eular.3911

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The regulatory dendritic cell marker C1q is a potent inhibitor of allergic inflammation

Autor: Nathalie Berjont, Charlotte Gary, Bernhard Ryffel, Laurent Mascarell, Claire Gueguen, David Klatzmann, Sabi Airouche, Philippe Moingeon, Bertrand Bellier, V Baron-Bodo, Gwladys Fourcade, Dieudonnée Togbe

Publikováno v: Mucosal Immunology
Mucosal Immunology, Nature Pub. Group, 2017, 10 (3), pp.695-704. ⟨10.1038/mi.2016.87⟩
Mucosal Immunology, 2017, 10 (3), pp.695-704. ⟨10.1038/mi.2016.87⟩

The complement subunit C1q was recently identified as a marker for monocyte-derived regulatory dendritic cells supporting the differentiation of interleukin (IL)-10-secreting CD4+ T cells with a suppressive activity. Furthermore, C1q expression is up

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3020e0725ca460045a84958a8ef2e95
https://hal-cnrs.archives-ouvertes.fr/hal-02126459

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