Zobrazeno 1 - 10
of 933
pro vyhledávání: '"Bertram Wiedenmann"'
Autor:
Naveen Kumar, Pon Ganish Prakash, Christian Wentland, Shilpa Mary Kurian, Gaurav Jethva, Volker Brinkmann, Hans-Joachim Mollenkopf, Tobias Krammer, Christophe Toussaint, Antoine-Emmanuel Saliba, Matthias Biebl, Christian Jürgensen, Bertram Wiedenmann, Thomas F. Meyer, Rajendra Kumar Gurumurthy, Cindrilla Chumduri
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The gastroesophageal squamocolumnar junction (GE-SCJ) is a critical tissue interface between the esophagus and stomach, with significant relevance in the pathophysiology of gastrointestinal diseases. Despite this, the molecular mechanisms un
Externí odkaz:
https://doaj.org/article/92e5c859ad5a452d9912442eb093da20
Autor:
Simon L. April-Monn, Philipp Kirchner, Katharina Detjen, Konstantin Bräutigam, Mafalda A. Trippel, Tobias Grob, Cyril Statzer, Renaud S. Maire, Attila Kollàr, Aziz Chouchane, Catarina A. Kunze, David Horst, Martin C. Sadowski, Jörg Schrader, Ilaria Marinoni, Bertram Wiedenmann, Aurel Perren
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-14 (2024)
Abstract There are no therapeutic predictive biomarkers or representative preclinical models for high-grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN), a highly aggressive, fatal, and heterogeneous malignancy. We established patient-de
Externí odkaz:
https://doaj.org/article/4501b816ee864b8c8c471a5b031bef76
Autor:
Felix Bolduan, Alexandra Wetzel, Yvonne Giesecke, Ines Eichhorn, Natalia Alenina, Michael Bader, Thomas E. Willnow, Bertram Wiedenmann, Michael Sigal
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
A subset of neuroendocrine tumors (NETs) can cause an excessive secretion of hormones, neuropeptides, and biogenic amines into the bloodstream. These so-called functional NETs evoke a hormone-related disease and lead to several different syndromes, d
Externí odkaz:
https://doaj.org/article/b881f1739a044e80897f6303970ea413
Publikováno v:
Cancer Medicine, Vol 12, Iss 13, Pp 13978-13990 (2023)
Abstract Hepatocellular carcinoma (HCC) is a major cause of death among patients with liver cirrhosis. The rise of immuno‐oncology has revolutionized treatment for advanced HCC. However, most pivotal randomized controlled trials have excluded patie
Externí odkaz:
https://doaj.org/article/747696b1fb5b4f988dbf26409b98fa8a
Autor:
Raik Otto, Katharina M. Detjen, Pamela Riemer, Melanie Fattohi, Carsten Grötzinger, Guido Rindi, Bertram Wiedenmann, Christine Sers, Ulf Leser
Publikováno v:
Cancers, Vol 15, Iss 3, p 936 (2023)
Pancreatic neuroendocrine neoplasms (panNENs) are a rare yet diverse type of neoplasia whose precise clinical–pathological classification is frequently challenging. Since incorrect classifications can affect treatment decisions, additional tools wh
Externí odkaz:
https://doaj.org/article/ac50b708828547168f96f3edc616fba1
Autor:
Bertram Wiedenmann, Tom Luedde, Frank Tacke, Linda Hammerich, Christoph Roderburg, Katharina Detjen, Raik Otto, Yvonne Giesecke, Lukas Geisler, Pamela Riemer, Henning Jann, Carsten Grötzinger, Christine Sers, Ulf Leser, Michael Sigal
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/157eb3c3b6aa4679bea3534f33cc367c
Autor:
Sachindra Sachindra, Teresa Hellberg, Samantha Exner, Sonal Prasad, Nicola Beindorff, Stephan Rogalla, Richard Kimura, Sanjiv Sam Gambhir, Bertram Wiedenmann, Carsten Grötzinger
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
IntroductionPancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignant neoplasms, as many cases go undetected until they reach an advanced stage. Integrin αvβ6 is a cell surface receptor overexpressed in PDAC. Consequently, it
Externí odkaz:
https://doaj.org/article/18078cbd95024e42825a22c9aa53eef7
Secretin Receptor as a Target in Gastrointestinal Cancer: Expression Analysis and Ligand Development
Publikováno v:
Biomedicines, Vol 10, Iss 3, p 536 (2022)
Secretin was originally discovered as a gastrointestinal peptide that stimulates fluid secretion from the pancreas and liver and delays gastric emptying. In disease, a secretin receptor (SCTR) was found to occur as a splice variant in gastrinoma and
Externí odkaz:
https://doaj.org/article/0b82e9c7af0343fcb9ecc25aa21ffe6f
Autor:
Katharina M. Detjen, Raik Otto, Yvonne Giesecke, Lukas Geisler, Pamela Riemer, Henning Jann, Carsten Grötzinger, Christine Sers, Andreas Pascher, Tom Lüdde, Ulf Leser, Bertram Wiedenmann, Michael Sigal, Frank Tacke, Christoph Roderburg, Linda Hammerich
Publikováno v:
Cancers, Vol 13, Iss 17, p 4463 (2021)
Background: The clinical management of high-grade gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) is challenging due to disease heterogeneity, illustrating the need for reliable biomarkers facilitating patient stratification and guiding tre
Externí odkaz:
https://doaj.org/article/4ed6e4c7be6b4003a676e2a8522be1ad
Autor:
Uli Fehrenbach, Siyi Xin, Alexander Hartenstein, Timo Alexander Auer, Franziska Dräger, Konrad Froböse, Henning Jann, Martina Mogl, Holger Amthauer, Dominik Geisel, Timm Denecke, Bertram Wiedenmann, Tobias Penzkofer
Publikováno v:
Cancers, Vol 13, Iss 11, p 2726 (2021)
Background: Rapid quantification of liver metastasis for diagnosis and follow-up is an unmet medical need in patients with secondary liver malignancies. We present a 3D-quantification model of neuroendocrine liver metastases (NELM) using gadoxetic-ac
Externí odkaz:
https://doaj.org/article/5adadcb5bb3a4ff480fbfd2dbb5ef4df