Individual Organ Failure and Concomitant Risk of Mortality Differs According to the Type of Admission to ICU - A Retrospective Study of SOFA Score of 23,795 Patients.

Autor: Tobias M Bingold, Rolf Lefering, Kai Zacharowski, Patrick Meybohm, Christian Waydhas, Peter Rosenberger, Bertram Scheller, DIVI Intensive Care Registry Group

Publikováno v: PLoS ONE, Vol 10, Iss 8, p e0134329 (2015)

Organ dysfunction or failure after the first days of ICU treatment and subsequent mortality with respect to the type of intensive care unit (ICU) admission is poorly elucidated. Therefore we analyzed the association of ICU mortality and admission for

Externí odkaz: https://doaj.org/article/b97a517db33147a29ec23b53e58fda0e

The early activation of toll-like receptor (TLR)-3 initiates kidney injury after ischemia and reperfusion.

Autor: Patrick Paulus, Katrin Rupprecht, Patrick Baer, Nicholas Obermüller, Daniela Penzkofer, Christin Reissig, Bertram Scheller, Johannes Holfeld, Kai Zacharowski, Stefanie Dimmeler, Joelle Schlammes, Anja Urbschat

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e94366 (2014)

Acute kidney injury (AKI) is one of the most important complications in hospitalized patients and its pathomechanisms are not completely elucidated. We hypothesize that signaling via toll-like receptor (TLR)-3, a receptor that is activated upon bindi

Externí odkaz: https://doaj.org/article/a64b766c332d4f09a8e40d45a458e1e6

Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat.

Autor: Patrick Paulus, Pia Ockelmann, Sabine Tacke, Nora Karnowski, Peter Ellinghaus, Bertram Scheller, Johannes Holfeld, Anja Urbschat, Kai Zacharowski

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e39265 (2012)

The main goal of adequate organ preservation is to avoid further cellular metabolism during the phase of ischemia. However, modern preservation solutions do rarely achieve this target. In donor organs hypoxia and ischemia induce a broad spectrum of p

Externí odkaz: https://doaj.org/article/655c43de2e764a419255523a0b8825c6

Systemic TLR2 Antibody Application in Renal Ischaemia and Reperfusion Injury Decreases AKT Phosphorylation and Increases Apoptosis in the Mouse Kidney

Autor: Bertram Scheller, Vera Sprunck, Florian J Raimann, Thorsten J. Maier, Anja Urbschat, Rainer Hofmann, Axel Hegele, Jan Mersmann, Kai Zacharowski, Patrick C. Baer

Publikováno v: Urbschat, A, Baer, P, Zacharowski, K, Sprunck, V, Scheller, B, Raimann, F, Maier, T J, Hegele, A, Hofmann, R & Mersmann, J 2018, ' Systemic TLR2 Antibody Application in Renal Ischaemia and Reperfusion Injury Decreases AKT Phosphorylation and Increases Apoptosis in the Mouse Kidney ', Basic & Clinical Pharmacology & Toxicology, vol. 122, no. 2, pp. 223-232 . https://doi.org/10.1111/bcpt.12896

Acute kidney injury remains an important cause of renal dysfunction. In this context, Toll-like receptors have been demonstrated to play a critical role in the induction of innate and inflammatory responses. Among these, Toll-like receptor 2 (TLR2) i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8740b20e0ad1a3d1f08d1bc65ac5ff56
https://doi.org/10.1111/bcpt.12896

Mortality of Septic Mice Strongly Correlates With Adrenal Gland Inflammation

Autor: Waldemar Kanczkowski, Bertram Scheller, Lars Heerdegen, Stefan R. Bornstein, Nguyen Tran, Ajith Kantharajah, Kai Zacharowski, Stefan Dröse, Carla Jennewein

Publikováno v: Critical Care Medicine. 44:e190-e199

OBJECTIVES Sepsis and septic shock are commonly present in the ICU and accompanied by significant morbidity, mortality, and cost. The frequency of secondary adrenal insufficiency in sepsis remains open to debate and a challenge to identify and treat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1908bcd547d0b018595a46d4a1acd8ce
https://doi.org/10.1097/ccm.0000000000001373