The Fibrin Cleavage Product Bβ15-42 Channels Endothelial and Tubular Regeneration in the Post-acute Course During Murine Renal Ischemia Reperfusion Injury

Autor: Dania Fischer, Christopher Seifen, Patrick Baer, Michaela Jung, Christina Mertens, Bertram Scheller, Kai Zacharowski, Rainer Hofmann, Thorsten J. Maier, Anja Urbschat

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

Early and adequate restoration of endothelial and tubular renal function is a substantial step during regeneration after ischemia reperfusion (IR) injury, occurring, e.g., in kidney transplantation, renal surgery, and sepsis. While tubular epithelial

Externí odkaz: https://doaj.org/article/a8d5a08322b14f9fb460cd753ffdb188

The small fibrinopeptide Bβ15-42 as renoprotective agent preserving the endothelial and vascular integrity in early ischemia reperfusion injury in the mouse kidney.

Autor: Anja Urbschat, Kai Zacharowski, Nicholas Obermüller, Katrin Rupprecht, Daniela Penzkofer, Carla Jennewein, Nguyen Tran, Bertram Scheller, Stefanie Dimmeler, Patrick Paulus

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e84432 (2014)

Disruption of the renal endothelial integrity is pivotal for the development of a vascular leak, tissue edema and consequently acute kidney injury. Kidney ischemia amplifies endothelial activation and up-regulation of pro-inflammatory mechanisms. Aft

Externí odkaz: https://doaj.org/article/9b9c95015f8b4b5b84c3849bcd0bd1ae

Prednisolone as preservation additive prevents from ischemia reperfusion injury in a rat model of orthotopic lung transplantation.

Autor: Patrick Paulus, Johannes Holfeld, Anja Urbschat, Haitham Mutlak, Pia Alexandra Ockelmann, Sabine Tacke, Kai Zacharowski, Christin Reissig, David Stay, Bertram Scheller

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e73298 (2013)

The lung is, more than other solid organs, susceptible for ischemia reperfusion injury after orthotopic transplantation. Corticosteroids are known to potently suppress pro-inflammatory processes when given in the post-operative setting or during reje

Externí odkaz: https://doaj.org/article/bd2ce137a9a84f3eb43fbba4ff3ce8b2

Systemic TLR2 Antibody Application in Renal Ischaemia and Reperfusion Injury Decreases AKT Phosphorylation and Increases Apoptosis in the Mouse Kidney

Autor: Bertram Scheller, Vera Sprunck, Florian J Raimann, Thorsten J. Maier, Anja Urbschat, Rainer Hofmann, Axel Hegele, Jan Mersmann, Kai Zacharowski, Patrick C. Baer

Publikováno v: Urbschat, A, Baer, P, Zacharowski, K, Sprunck, V, Scheller, B, Raimann, F, Maier, T J, Hegele, A, Hofmann, R & Mersmann, J 2018, ' Systemic TLR2 Antibody Application in Renal Ischaemia and Reperfusion Injury Decreases AKT Phosphorylation and Increases Apoptosis in the Mouse Kidney ', Basic & Clinical Pharmacology & Toxicology, vol. 122, no. 2, pp. 223-232 . https://doi.org/10.1111/bcpt.12896

Acute kidney injury remains an important cause of renal dysfunction. In this context, Toll-like receptors have been demonstrated to play a critical role in the induction of innate and inflammatory responses. Among these, Toll-like receptor 2 (TLR2) i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8740b20e0ad1a3d1f08d1bc65ac5ff56
https://doi.org/10.1111/bcpt.12896

Mortality of Septic Mice Strongly Correlates With Adrenal Gland Inflammation

Autor: Waldemar Kanczkowski, Bertram Scheller, Lars Heerdegen, Stefan R. Bornstein, Nguyen Tran, Ajith Kantharajah, Kai Zacharowski, Stefan Dröse, Carla Jennewein

Publikováno v: Critical Care Medicine. 44:e190-e199

OBJECTIVES Sepsis and septic shock are commonly present in the ICU and accompanied by significant morbidity, mortality, and cost. The frequency of secondary adrenal insufficiency in sepsis remains open to debate and a challenge to identify and treat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1908bcd547d0b018595a46d4a1acd8ce
https://doi.org/10.1097/ccm.0000000000001373