Gallbladder Cancer Risk and Indigenous South American Mapuche Ancestry: Instrumental Variable Analysis Using Ancestry-Informative Markers.

Autor: Zollner L; Statistical Genetics Research Group, Institute of Medical Biometry, Heidelberg University, 69120 Heidelberg, Germany.; Division of Proteomics of Stem Cells and Cancer, German Cancer Research Center, 69120 Heidelberg, Germany., Boekstegers F; Statistical Genetics Research Group, Institute of Medical Biometry, Heidelberg University, 69120 Heidelberg, Germany., Barahona Ponce C; Statistical Genetics Research Group, Institute of Medical Biometry, Heidelberg University, 69120 Heidelberg, Germany., Scherer D; Statistical Genetics Research Group, Institute of Medical Biometry, Heidelberg University, 69120 Heidelberg, Germany., Marcelain K; Department of Basic and Clinical Oncology, Medical Faculty, University of Chile, Santiago 8380000, Chile., Gárate-Calderón V; Statistical Genetics Research Group, Institute of Medical Biometry, Heidelberg University, 69120 Heidelberg, Germany.; Department of Basic and Clinical Oncology, Medical Faculty, University of Chile, Santiago 8380000, Chile., Waldenberger M; Research Unit Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Neuherberg, Germany., Morales E; Hospital Regional de Talca, Talca 3460000, Chile.; Facultad de Medicina, Universidad Católica del Maule, Talca 3460000, Chile., Rojas A; Facultad de Medicina, Universidad Católica del Maule, Talca 3460000, Chile., Munoz C; Hospital Regional de Talca, Talca 3460000, Chile.; Facultad de Medicina, Universidad Católica del Maule, Talca 3460000, Chile., Retamales J; Instituto Nacional del Cáncer, Santiago 7500650, Chile., De Toro G; Hospital de Puerto Montt, Puerto Montt 5480000, Chile.; Escuela de Tecnología Médica, Universidad Austral de Chile sede Puerto Montt, Puerto Montt 5480000, Chile., Kortmann AV; Hospital de Puerto Montt, Puerto Montt 5480000, Chile., Barajas O; Department of Basic and Clinical Oncology, Medical Faculty, University of Chile, Santiago 8380000, Chile.; Hospital Clínico Universidad de Chile, Santiago 8380456, Chile., Rivera MT; Hospital del Salvador, Santiago 7500922, Chile., Cortés A; Hospital del Salvador, Santiago 7500922, Chile., Loader D; Hospital Padre Hurtado, Santiago 8880456, Chile., Saavedra J; Hospital Padre Hurtado, Santiago 8880456, Chile., Gutiérrez L; Hospital San Juan de Dios, Santiago 8320000, Chile., Ortega A; Hospital Regional, Arica 1000000, Chile., Bertrán ME; Unidad Registro Hospitalario de Cáncer, Hospital Base de Valdivia, Valdivia 5090146, Chile., Bartolotti L; Hospital Base de Valdivia, Valdivia 5090000, Chile., Gabler F; Hospital San Borja Arriarán, Santiago 8320000, Chile., Campos M; Hospital San Borja Arriarán, Santiago 8320000, Chile., Alvarado J; Hospital Regional Guillermo Grant Benavente, Concepción 4070386, Chile., Moisán F; Hospital Regional Guillermo Grant Benavente, Concepción 4070386, Chile., Spencer L; Hospital Regional Guillermo Grant Benavente, Concepción 4070386, Chile., Nervi B; Departamento de Hematología y Oncología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago 8330077, Chile., Carvajal D; Facultad de Medicina, Clínica Alemana Universidad del Desarrollo, Santiago 7650568, Chile., Losada H; Departamento de Cirugía, Universidad de la Frontera, Temuco 4780000, Chile., Almau M; Hospital de Rancagua, Rancagua 2820000, Chile., Fernández P; Hospital de Rancagua, Rancagua 2820000, Chile., Olloquequi J; Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain.; Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Talca 3460000, Chile., Carter AR; MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 1UD, UK., Miquel Poblete JF; Departamento de Gastroenterología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago 8320000, Chile., Bustos BI; Ken and Ruth Davee Department of Neurology and Simpson Querrey Center for Neurogenetics, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA., Fuentes Guajardo M; Departamento de Tecnología Médica, Facultad de Ciencias de la Salud, Tarapacá University, Arica 1000815, Chile., Gonzalez-Jose R; Instituto Patagónico de Ciencias Sociales y Humanas, Centro Nacional Patagónico, CONICET, Puerto Madryn U9120ACD, Argentina., Bortolini MC; Instituto de Biociências, Universidad Federal do Rio Grande do Sul, Puerto Alegre 15053, Brazil., Acuña-Alonzo V; National Institute of Anthropology and History, Mexico City 06600, Mexico., Gallo C; Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima 15102, Peru., Ruiz Linares A; Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center of Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai 200434, China.; ADES (Anthropologie Bio-Culturelle, Droit, Éthique et Santé), UFR de Médecine, Aix-Marseille University, 13007 Marseille, France.; Department of Genetics, Evolution and Environment and UCL Genetics Institute, University College London, London WC1E 6BT, UK., Rothhammer F; Instituto de Alta Investigación, Tarapacá University, Arica 1000000, Chile., Lorenzo Bermejo J; Statistical Genetics Research Group, Institute of Medical Biometry, Heidelberg University, 69120 Heidelberg, Germany.; Department of Biostatistics for Precision Oncology, Institut de Cancérologie Strasbourg Europe, 67200 Strasbourg, France.

Publikováno v: Cancers [Cancers (Basel)] 2023 Aug 09; Vol. 15 (16). Date of Electronic Publication: 2023 Aug 09.

Gallstones, Body Mass Index, C-Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and European Genotype Data.

Autor: Barahona Ponce C; Statistical Genetics Group, Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany.; Department of Basic and Clinical Oncology, Medical Faculty, University of Chile, Santiago de Chile, Chile., Scherer D; Statistical Genetics Group, Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany., Brinster R; Statistical Genetics Group, Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany., Boekstegers F; Statistical Genetics Group, Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany., Marcelain K; Department of Basic and Clinical Oncology, Medical Faculty, University of Chile, Santiago de Chile, Chile., Gárate-Calderón V; Statistical Genetics Group, Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany.; Department of Basic and Clinical Oncology, Medical Faculty, University of Chile, Santiago de Chile, Chile., Müller B; Servicio de Oncología Médica, Instituto Nacional del Cáncer, Santiago, Chile., de Toro G; Escuela de Tecnologia Medica, Universidad Austral de Chile sede Puerto Montt, Puerto Montt, Chile.; Servicio de Anatomía Patológica, Hospital de Puerto Montt, Puerto Montt, Chile., Retamales J; Servicio de Oncología Médica, Instituto Nacional del Cáncer, Santiago, Chile., Barajas O; Department of Basic and Clinical Oncology, Medical Faculty, University of Chile, Santiago de Chile, Chile.; Department of Basic and Clinical Oncology, Medical Faculty, University of Chile, Santiago, Chile.; Oncology Department, Hospital Clínico Universidad de Chile, Santiago, Chile., Ahumada M; Department of Basic and Clinical Oncology, Medical Faculty, University of Chile, Santiago de Chile, Chile.; Department of Basic and Clinical Oncology, Medical Faculty, University of Chile, Santiago, Chile.; Oncology Department, Hospital Clínico Universidad de Chile, Santiago, Chile., Morales E; Facultad de Medicina, Universidad Católica del Maule, Talca, Chile.; Unidad de Anatomía Patológica del Hospital Regional de Talca, Talca, Chile., Rojas A; Laboratorio de Investigaciones Biomédicas en la Facultad de Medicina, Universidad Católica del Maule, Talca, Chile., Sanhueza V; Servicio de Anatomía Patológica, Hospital Padre Hurtado, Santiago, Chile., Loader D; Servicio de Anatomía Patológica, Hospital Padre Hurtado, Santiago, Chile., Rivera MT; Servicio de Anatomía Patológica, Hospital del Salvador, Santiago, Chile., Gutiérrez L; Servicio de Anatomía Patológica, Hospital San Juan de Dios, Santiago, Chile., Bernal G; Laboratory of Molecular and Cellular Biology of Cancer (CancerLab), Department of Biomedical Sciences, Faculty of Medicine, Universidad Católica del Norte, Coquimbo, Chile., Ortega A; Servicio de Anatomía Patológica, Hospital Regional, Arica, Chile., Montalvo D; Department of Surgery, Hospital Juan Noe Crevani, Arica, Chile., Portiño S; Department of Basic and Clinical Oncology, Medical Faculty, University of Chile, Santiago, Chile.; Oncology Department, Hospital Clínico Universidad de Chile, Santiago, Chile., Bertrán ME; Secretaría Regional Ministerial de Salud, Ministerio de Salud, Valdivia, Chile., Gabler F; Servicio de Anatomía Patológica, Hospital San Borja Arriarán, Santiago, Chile., Spencer L; Servicio de Anatomía Patológica, Hospital Regional Guillermo Grant Benavente, Concepción, Chile., Olloquequi J; Laboratory of Cellular and Molecular Pathology, Instituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Talca, Chile., Fischer C; Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany., Jenab M; International Agency for Research on Cancer, Lyon, France., Aleksandrova K; Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Germany., Katzke V; Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany., Weiderpass E; International Agency for Research on Cancer, World Health Organization, Lyon, France., Bonet C; Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Barcelona, Spain., Moradi T; Division of Epidemiology, Department of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Fischer K; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Bossers W; The Lifelines Cohort Study, Groningen, Netherlands., Brenner H; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.; Division of Preventive Oncology, German Cancer Research Center, National Center for Tumor Diseases, Heidelberg, Germany.; German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany., Hveem K; The Nord-Trøndelag Health Research Centre, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Public Health and Nursing, K.G. Jebsen Centre for Genetic Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway., Eklund N; Genomics and Biobank, National Institute for Health and Welfare, Helsinki, Finland., Völker U; Interfakultäres Institut für Genetik und Funktionelle Genomforschung, Universitätsmedizin Greifswald, Germany., Waldenberger M; Research Unit of Molecular Epidemiology and Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Fuentes Guajardo M; Instituto de Alta Investigación, Tarapacá University, Arica, Chile., Gonzalez-Jose R; Centro Nacional Patagónico, Instituto Patagónico de Ciencias Sociales y Humanas, CONICET, Puerto Madryn, Argentina., Bedoya G; Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia, Medellín, Colombia., Bortolini MC; Instituto de Biociências, Universidad Federal do Rio Grande do Sul, Puerto Alegre, Brazil., Canizales-Quinteros S; Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de México, México., Gallo C; Unidad de Neurobiología Molecular y Genética, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru., Ruiz-Linares A; Ministry of Education Key Laboratory of Contemporary Anthropology and Collaborative Innovation Center of Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai, China.; Aix-Marseille Université, CNRS, EFS, ADES, Marseille, France.; Department of Genetics, Evolution and Environment, and UCL Genetics Institute, University College London, London, UK., Rothhammer F; Instituto de Alta Investigación, Tarapacá University, Arica, Chile., Lorenzo Bermejo J; Statistical Genetics Group, Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany.

Publikováno v: Hepatology (Baltimore, Md.) [Hepatology] 2021 May; Vol. 73 (5), pp. 1783-1796.