Association of the thrombomodulin gene c.1418C>T polymorphism with thrombomodulin levels and with venous thrombosis risk

Autor: Navarro S, Medina P, Bonet E, Corral J, Martínez-Sales V, Martos L, Rivera M, Roselló-Lletí E, Alberca I, Roldán V, Mira Y, Ferrando F, Estellés A, Vicente V, Bertina RM, España F

Publikováno v: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname

To investigate the association of the THBD c.1418C>T polymorphism, which encodes for the replacement of Ala455 by Val in thrombomodulin (TM), with venous thromboembolism (VTE), plasma soluble TM, and activated protein C levels. In addition, human umb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::6a06d9ecf88895932846e6ef5d39a536
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=1385

Haplotypes of the EPCR gene, prothrombin levels, and the risk of venous thrombosis in carriers of the prothrombin G20210A mutation

Autor: Navarro S, Medina P, Mira Y, Estelles A, Villa P, Ferrando F, Vayá A, Bertina RM, España F

Publikováno v: HAEMATOLOGICA
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname

Haplotypes A1 and A3 in the endothelial protein C receptor (EPCR) gene are tagged by 4678G/C and 4600A/G respectively. We assessed whether these haplotypes modify the risk of venous thromboembolism in carriers of the prothrombin 20210A allele.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::e3b161323d7b6d7a7a94de18e9981936
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=4079

Influence of the 4600A/G and 4678G/C polymorphisms in the endothelial protein C receptor (EPCR) gene on the risk of venous thromboembolism in carriers of factor V Leiden

Autor: Medina P, Navarro S, Estelles A, Vayá A, Bertina RM, España F

Publikováno v: THROMBOSIS AND HAEMOSTASIS
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname

Two polymorphisms in the endothelial protein C receptor (EPCR) gene, 4600A/G and 4678G/C, have been reported to influence the risk of venous thromboembolism (VTE). The objective of this study was to assess whether these polymorphisms modify the risk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::32b3e53be4ae7cde78f9e8ced3efe819
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=4085

Association between thrombin activatable fibrinolysis inhibitor genotype and levels in plasma: Comparison of different assays

Autor: Guimeras, A, van Tilburg, NH, Vos, HL, Bertina, RM, Rijken, Dick

Publikováno v: British Journal of Haematology, 5, 124, 659-665
British Journal of Haematology, 124, 659-665. Wiley-Blackwell Publishing Ltd

Thrombin activatable fibrinolysis inhibitor (TAFI) antigen levels exhibit a large interindividual variability in which genetic control seems to play a major role. However, recent reports have questioned the association between TAFI concentration and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::22dc9e4185eca14ebf9d01c71be406fe
http://resolver.tudelft.nl/uuid:2aec4834-79d7-4f44-89ca-4fc8aa12dace

Identification of evolutionarily invariant sequences in the protein C gene promoter

Autor: C A Spek, Bertina Rm, Reitsma Ph

Publikováno v: Journal of molecular evolution, 47(6), 663-669. Springer New York

Recent studies on human protein C gene expression have revealed the presence of three transcription factor binding sites in close proximity to the transcription start site. Binding sites for the liver-enriched hepatocyte nuclear factors 1 and 3 (HNF-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a2dd80aefa5c8d8c8cbaea9ac0155aa
https://pubmed.ncbi.nlm.nih.gov/9847407