Zobrazeno 1 - 10
of 290
pro vyhledávání: '"Bertil Samuelsson"'
Autor:
Jade L. Ross, Urszula Grabowska, Karen Fuller, Kevin M. Lawrence, Masahiro Shiroo, Timothy J. Chambers, Bertil Samuelsson
Publikováno v:
Bone. 145:115354
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2d9653df1b835d85cf32e09df2b33d6
https://doi.org/10.1016/j.bone.2020.115354
https://doi.org/10.1016/j.bone.2020.115354
Publikováno v:
2017 International Symposium on Electrical Insulating Materials (ISEIM).
The high voltage condenser bushing is a critical component found in all electrical networks and whose failure can have serious consequences. Thermal and electrical stresses, ambient conditions, and other factors place high demands on bushings. Proper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20ae0454a9c594bc0e58791cbe0c3134
https://doi.org/10.23919/iseim.2017.8166596
https://doi.org/10.23919/iseim.2017.8166596
Autor:
Hans Wallberg, Mats Larhed, Anders Hallberg, Johan Unge, Jean-Baptiste Veron, Bertil Samuelsson, Advait Arun Joshi, Åsa Rosenquist
Publikováno v:
Journal of Medicinal Chemistry. 56:8999-9007
To study P1-P3 macrocyclizations of previously reported tertiary-alcohol-comprising HIV-1 protease inhibitors (PIs), three new 14- and 15-member macrocyclic PIs were designed, synthesized by ring-closing metathesis, and evaluated alongside with 10 no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce6fc17f6916252a2c3fa2f6d2bc2df2
https://doi.org/10.1021/jm400811d
https://doi.org/10.1021/jm400811d
Autor:
Jimmy Lindberg, Veronica Sandgren, Per-Ola Johansson, Bertil Samuelsson, Tatiana Agback, Oscar Belda, Anders Dahlgren, Ingemar Kvarnström
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:4377-4389
A series of P1-P3 linked macrocyclic BACE-1 inhibitors containing a hydroxyethylamine (HEA) isostere scaffold has been synthesized. All inhibitors comprise a toluene or N-phenylmethanesulfonamide P2 moiety. Excellent BACE-1 potencies, both in enzymat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18d5fc4bd480a7a3d040ed0dfd1b0c8a
https://doi.org/10.1016/j.bmc.2012.05.039
https://doi.org/10.1016/j.bmc.2012.05.039
Autor:
Johan Unge, Alejandro Trejos, Xiongyu Wu, Mats Larhed, Per Öhrngren, Lotta Vrang, Åsa Rosenquist, Advait Arun Joshi, Magnus Persson, Hans Wallberg, Riina K. Arvela, Bertil Samuelsson
Publikováno v:
Journal of Medicinal Chemistry
In an effort to identify a new class of druglike HIV-1 protease inhibitors, four different stereopure β-hydroxy γ-lactam-containing inhibitors have been synthesized, biologically evaluated, and cocrystallized. The impact of the tether length of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e08f363ec392aa48e91c23e6a9917f
http://europepmc.org/articles/PMC3310203
http://europepmc.org/articles/PMC3310203
Autor:
Pierre Raboisson, Sophie Lachau-Durand, Åsa Rosenquist, Gregory Fanning, Bertil Samuelsson, Tim Hugo Maria Jonckers, Magnus Nilsson, Laurent Leclercq, Leen Vijgen, Pascale Dehertogh, Megan H. Powdrill, Svea Rawe, Christel Van den Eynde, Elena Sjuvarsson, Jan Martin Berke, Els Fransen, Staffan Eriksson, Tse-I Lin, Matthias Götte
Publikováno v:
Antimicrobial Agents and Chemotherapy. 55:3812-3820
Chronic infection with hepatitis C virus (HCV) is a major global health burden and is associated with an increased risk of liver cirrhosis and hepatocellular carcinoma. Current therapy for HCV infection has limited efficacy, particularly against geno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ef2c3207d3c628a9891139fdceb21f
https://doi.org/10.1128/aac.00214-11
https://doi.org/10.1128/aac.00214-11
Autor:
Daniel Wiktelius, Oscar Belda, Susanne Sedig, Katarina Jansson, Bertil Samuelsson, Tatiana Agback, Neera Borkakoti, Elizabeth Hamelink, Anders Eneroth, Dean Derbyshire, Ian R. Henderson, Christian Sund, Christer Sahlberg, Lotta Vrang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:358-362
Two types of P1-P3-linked macrocyclic renin inhibitors containing the hydroxyethylene isostere (HE) scaffold just outside the macrocyclic ring have been synthesized. An aromatic or aliphatic substituent (P3sp) was introduced in the macrocyclic ring a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e33fedf686b780e1bf07b8731feb8bf3
https://doi.org/10.1016/j.bmcl.2010.10.140
https://doi.org/10.1016/j.bmcl.2010.10.140
Autor:
Fredrik Wångsell, Jimmy Lindberg, Mats Larhed, Bertil Samuelsson, Patrik Nordeman, Åsa Rosenquist, Jonas Sävmarker, Rikard Emanuelsson, Katarina Jansson
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:145-155
Inhibition of the BACE-1 protease enzyme has over the recent decade developed into a promising drug strategy for Alzheimer therapy. In this report, more than 20 new BACE-1 protease inhibitors based on α-phenylnorstatine, α-benzylnorstatine, iso-ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4429b92e15243f0b1464ba9a0f14b833
https://doi.org/10.1016/j.bmc.2010.11.042
https://doi.org/10.1016/j.bmc.2010.11.042
Autor:
Charlotta Lindquist, Stefan Lindström, Tse-I Lin, Magnus Nilsson, Tatiana Agback, Horst Wähling, Pierre Jean-Marie Bernard Raboisson, Mikael Pelcman, Wigerinck Piet Tom Bert Paul, Pia Cecilia Kahnberg, Kurt Benkestock, Herman de Kock, Michael Edlund, Anders Eneroth, Elizabeth Hamelink, Anna Karin Belfrage, Susana Ayesa, Ylva Terelius, Kristina Wikström, Åsa Rosenquist, Lotta Vrang, Kenneth Simmen, Bertil Samuelsson, Christina Rydergård
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4004-4011
Novel NS3/4A protease inhibitors comprising quinazoline derivatives as P2 substituent were synthesized. High potency inhibitors displaying advantageous PK properties have been obtained through the optimization of quinazoline P2 substituents in three
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd304710cfabba8d5ae2d3233ceb229
https://doi.org/10.1016/j.bmcl.2010.05.029
https://doi.org/10.1016/j.bmcl.2010.05.029
Autor:
Anders Karlén, Advait Arun Joshi, Bertil Samuelsson, Mats Larhed, Lotta Vrang, Anders Hallberg, Anna Ax, Kristina M. Orrling
Publikováno v:
Tetrahedron. 66:4049-4056
A set of 11 non-symmetric cyclic sulfamide HIV-1 protease inhibitors were synthesized and evaluated. The use of a key microwave-assisted silver(I) oxide mediated selective mono N-benzylation reacti ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abc402d3402ec3df760561da054add2b
https://doi.org/10.1016/j.tet.2010.04.023
https://doi.org/10.1016/j.tet.2010.04.023