Výsledky vyhledávání - "Bertil Hille"

This retrospective traces the hypothesis of ion channels from an early statement in a 1970 essay in this journal (Hille, B., 1970, Prog. Biophys. Mol. Biol. 21, 1–32) to its realization today in biophysical, molecular, biochemical, and structural t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6877afe858b4180958cfec145f9e54ce
https://doi.org/10.1016/j.pbiomolbio.2021.11.003

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Akademický článek

Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis

Autor: Alexander M Walter, Rainer Müller, Bassam Tawfik, Keimpe DB Wierda, Paulo S Pinheiro, André Nadler, Anthony W McCarthy, Iwona Ziomkiewicz, Martin Kruse, Gregor Reither, Jens Rettig, Martin Lehmann, Volker Haucke, Bertil Hille, Carsten Schultz, Jakob Balslev Sørensen

Publikováno v: eLife, Vol 6 (2017)

Phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] is essential for exocytosis. Classical ways of manipulating PI(4,5)P2 levels are slower than its metabolism, making it difficult to distinguish effects of PI(4,5)P2 from those of its metabolites. We d

Externí odkaz: https://doaj.org/article/aabde6eab85749a18c97c983d851505d

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Akademický článek

Proximal clustering between BK and CaV1.3 channels promotes functional coupling and BK channel activation at low voltage

Autor: Oscar Vivas, Claudia M Moreno, Luis F Santana, Bertil Hille

Publikováno v: eLife, Vol 6 (2017)

CaV-channel dependent activation of BK channels is critical for feedback control of both calcium influx and cell excitability. Here we addressed the functional and spatial interaction between BK and CaV1.3 channels, unique CaV1 channels that activate

Externí odkaz: https://doaj.org/article/1c0ed96f9e2e4db5ac7c0ced337cab1a

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Biophysical physiology of phosphoinositide rapid dynamics and regulation in living cells

Autor: Jill B. Jensen, Bjoern H. Falkenburger, Eamonn J. Dickson, Lizbeth de la Cruz, Gucan Dai, Jongyun Myeong, Seung-Ryoung Jung, Martin Kruse, Oscar Vivas, Byung-Chang Suh, Bertil Hille

Publikováno v: The Journal of general physiology. 154(6)

Phosphoinositide membrane lipids are ubiquitous low-abundance signaling molecules. They direct many physiological processes that involve ion channels, membrane identification, fusion of membrane vesicles, and vesicular endocytosis. Pools of these lip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b95fafeb516458aaaf5e2e006e57b82
https://pubmed.ncbi.nlm.nih.gov/35583815

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Allosteric modulation of alternatively spliced Ca 2+ -activated Cl − channels TMEM16A by PI(4,5)P 2 and CaMKII

Autor: Seung-Ryoung Jung, Kwon-Woo Kim, Byung-Chang Suh, Bertil Hille, Joo Hyun Nam, Woori Ko, Jun-Hee Yeon, Cheon-Gyu Park

Publikováno v: Proceedings of the National Academy of Sciences. 117:30787-30798

Transmembrane 16A (TMEM16A, anoctamin1), 1 of 10 TMEM16 family proteins, is a Cl- channel activated by intracellular Ca2+ and membrane voltage. This channel is also regulated by the membrane phospholipid phosphatidylinositol 4,5-bisphosphate [PI(4,5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35e69c92c6be30c943f729374376db6e
https://doi.org/10.1073/pnas.2014520117

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