Výsledky vyhledávání - "Berthold J Vilner"

Structural similitudes between cytotoxic antiestrogen-binding site (AEBS) ligands and cytotoxic sigma receptor ligands. Evidence for a relationship between cytotoxicity and affinity for AEBS or sigma-2 receptor but not for sigma-1 receptor

Autor: Marc Poirot, Sylvie Daunes, Jean-Charles Faye, Wayne D. Bowen, Berthold J Vilner, Blandine Kedjouar, Alain Klaebe

Publikováno v: Biochemical Pharmacology
Biochemical Pharmacology, 1999, 58, pp.1927-39
Biochemical Pharmacology, Elsevier, 1999, 58, pp.1927-39

1-Benzyl-4-(N-2-pyrrolidinylethoxy)benzene (PBPE) is a cytotoxic derivative of the antitumoral drug tamoxifen. PBPE binds with high-affinity and specificity to the microsomal antiestrogen-binding site (AEBS). PBPE, as well as some other high-affinity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c87edff330fa8a49b4bf7e6243c2d7a
https://www.hal.inserm.fr/inserm-00090780

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