Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Berthold Drexler"'
Publikováno v:
BMC Anesthesiology, Vol 24, Iss 1, Pp 1-7 (2024)
Abstract Background Remimazolam is a relatively new benzodiazepine with growing use in procedural sedation and general anaesthesia. Initiated by case reports, the physical incompatibility of remimazolam with ringer’s acetated and ringer’s lactate
Externí odkaz:
https://doaj.org/article/c0ac51e92af442b9af7626ce37629808
Autor:
Matthias Kreuzer, Paul S. García, Verena Brucklacher-Waldert, Rebecca Claassen, Gerhard Schneider, Bernd Antkowiak, Berthold Drexler
Publikováno v:
BMC Neuroscience, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background The pharmacodynamic results of diazepam and ethanol administration are similar, in that each can mediate amnestic and sedative-hypnotic effects. Although each of these molecules effectively reduce the activity of central neurons,
Externí odkaz:
https://doaj.org/article/da43cec4337c42aab35ffe531f96c779
Autor:
Ana Kowark, Rolf Rossaint, András P. Keszei, Petra Bischoff, Michael Czaplik, Berthold Drexler, Peter Kienbaum, Moritz Kretzschmar, Christopher Rex, Thomas Saller, Gerhard Schneider, Martin Soehle, Mark Coburn, I-PROMOTE study group
Publikováno v:
Trials, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Introduction Premedication of surgical patients with benzodiazepines has become questionable regarding risk-benefit ratio and lack of evidence. Though preoperative benzodiazepines might alleviate preoperative anxiety, a higher risk for adver
Externí odkaz:
https://doaj.org/article/ca818d6b8db3459293b1337d309f9e79
Autor:
Björn Weiss, David Hilfrich, Gerald Vorderwülbecke, Maria Heinrich, Julius J. Grunow, Nicolas Paul, Jochen Kruppa, Bruno Neuner, Berthold Drexler, Felix Balzer, Claudia D. Spies
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 18, p 4091 (2021)
The benzodiazepine, midazolam, is one of the most frequently used sedatives in intensive care medicine, but it has an unfavorable pharmacokinetic profile when continuously applied. As a consequence, patients are frequently prolonged and more deeply s
Externí odkaz:
https://doaj.org/article/e4d21392f0ee4c88bddd223dc8fc3a7b
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract The benzodiazepine midazolam is widely used in critical care medicine. Midazolam has a clinically active metabolite, 1-hydroxymidazolam. The contribution of 1-hydroxymidazolam to the effects of midazolam is controversial. The aim of the curr
Externí odkaz:
https://doaj.org/article/369b1971f7f640e9b842c17fbe13f0a6
Autor:
Elena Neumann, Uwe Rudolph, Daniel E. Knutson, Guanguan Li, James M. Cook, Harald Hentschke, Bernd Antkowiak, Berthold Drexler
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2019)
Introduction: High frequency neuronal activity in the cerebral cortex can be induced by noxious stimulation during surgery, brain injury or poisoning. In this scenario, it is essential to block cortical hyperactivity to protect the brain against dama
Externí odkaz:
https://doaj.org/article/525d2cc5199f4e32ae8a8ec99135231c
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 7399 (2020)
The neurosteroid allopregnanolone (ALLO) causes unconsciousness by allosteric modulation of γ-aminobutyric acid type A (GABAA) receptors, but its actions on the spinal motor networks are unknown. We are therefore testing the hypothesis that ALLO att
Externí odkaz:
https://doaj.org/article/2966b55bd3c34aa6b413d9959b5eb4fc
Autor:
Matthias Kreuzer, Sergejus Butovas, Paul S García, Gerhard Schneider, Cornelius Schwarz, Uwe Rudolph, Bernd Antkowiak, Berthold Drexler
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 16, p 5844 (2020)
Background: General anesthetics depress neuronal activity. The depression and uncoupling of cortico-hippocampal activity may contribute to anesthetic-induced amnesia. However, the molecular targets involved in this process are not fully characterized
Externí odkaz:
https://doaj.org/article/e6939ba4ad384f50a4910415b8c4ad62
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60286 (2013)
BACKGROUND: The ventral horn is a major substrate in mediating the immobilizing properties of the volatile anesthetic sevoflurane in the spinal cord. In this neuronal network, action potential firing is controlled by GABA(A) and glycine receptors. Bo
Externí odkaz:
https://doaj.org/article/494512e6484e4b9386e8f875ffa44824
Autor:
Franziska M. Konrad, Angela S. Mayer, Lina M. Serna-Higuita, Helene Hurth, Marcos Tatagiba, Jörg Reutershan, Peter Rosenberger, Berthold Drexler
Publikováno v:
World Neurosurgery. 163:e335-e340
At our institution, patients undergoing neurosurgical procedures in the posterior cranial fossa are placed either in the semisitting or in the supine position. The major risk of the semisitting positioning is a venous air embolism (VAE), which may, h