Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Berthold Schenkel"'
Autor:
Julien Haber, Hannes Ausserwoeger, Claudio Lehmann, Lauriane Pillet, Berthold Schenkel, Bertrand Guélat
Publikováno v:
Organic Process Research & Development. 26:2456-2463
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ee78f00700f75c0b47b80b4d54223a5
https://doi.org/10.1021/acs.oprd.2c00123
https://doi.org/10.1021/acs.oprd.2c00123
Autor:
Paolo Filipponi, Francesco Venturoni, Roger Suremann, Alexander Streit, Silke Schoenebeck, Berthold Schenkel, Jutta Polenk, Lorenzo Piccioni, Ruairi O'Meadhra, Serena Mostarda, Julien Haber, Bertrand Guelat, Stefan Wegmann
Publikováno v:
CHIMIA, Vol 73, Iss 10 (2019)
Continuous processing has been demonstrated to be a superior approach when applied to fast and energetic chemical transformations. Indeed, whereas classical batch or semi-batch methods require cryogenic conditions and slow addition rates of reactive
Externí odkaz:
https://doaj.org/article/8b45399f595444dfb65a87015a87aa4e
Autor:
Berthold Schenkel, Jutta Polenk, Bertrand Guelat, Paolo Filipponi, Frederik Mortzfeld, Francesco Venturoni
Publikováno v:
Organic Process Research & Development. 24:2004-2016
A new method for the calorimetric characterization of high-energetic, fast reactions in flow mode has been developed. The use of an engineered flow reactor in combination with a process modelling software allowed the deconvolution of the reaction ent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dab25fc2c4adf6498699bc77b9370256
https://doi.org/10.1021/acs.oprd.0c00117
https://doi.org/10.1021/acs.oprd.0c00117
Autor:
Jakub Polak, Moritz von Stosch, Michael Sokolov, Lorenzo Piccioni, Alexander Streit, Berthold Schenkel, Bertrand Guelat
Publikováno v:
Computers & Chemical Engineering. 170:108127
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c39a1a4c3e0ee79515619fc0834d3818
https://doi.org/10.1016/j.compchemeng.2022.108127
https://doi.org/10.1016/j.compchemeng.2022.108127
Publikováno v:
Organicbiomolecular chemistry. 19(11)
We herein report two complementary strategies employing organolithium chemistry for the synthesis of glyoxal derivatives. Micro-mixer technology allows for the generation of unstable organometallic intermediates and their instantaneous in-line quench
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f82a39944011f5ef73618adc6b2d3636
https://pubmed.ncbi.nlm.nih.gov/33646230
https://pubmed.ncbi.nlm.nih.gov/33646230
Autor:
Ojo, Ebenezer, Osman, Musab, Mnemo, Mitchelle, Anwar, Ali, Houson, Ian, O'Meahdra, Ruairi, Berthold, Schenkel, Florence, Alastair
Publikováno v:
CMAC Annual Open Day
Early decision making of batch vs continuous and which type of crystalliser to select is a key decision point. Four different lab-scale (100’s ml) crystallisers were investigated and compared for multistage, multi--zone, antisolvent-cooling crystal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::31b4f7af893e617ce74ea94557a3b8ac
https://strathprints.strath.ac.uk/77231/1/Ojo_etal_CMAC_2020_Multistage_multi_zones_antisolvent_cooling_crystallisation_of_a_proprietary_API.pdf
https://strathprints.strath.ac.uk/77231/1/Ojo_etal_CMAC_2020_Multistage_multi_zones_antisolvent_cooling_crystallisation_of_a_proprietary_API.pdf
Autor:
Susanne Glowienke, Mark Meisenbach, Jerome Andre, Berthold Schenkel, Fabio Lima, Benjamin Martin, Alexander Marziale, Andreas Greb, Joerg Sedelmeier
Publikováno v:
Organic letters. 22(15)
An enabling continuous flow setup for handling of unstable organolithium intermediates and synthesis of heteroaryl sulfinates on a multigram scale is described. The developed continuous flow process allows for the synthesis and simple isolation of he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c1a7fb08980529d112326e54f273a84
https://pubmed.ncbi.nlm.nih.gov/32705872
https://pubmed.ncbi.nlm.nih.gov/32705872
Autor:
Wietfeld Bernhard, Florian Kleinbeck, Jingjing Wu, Liqun Zhao, Francesco Venturoni, Weichun Liu, Xiangguang Tian, Gai Yu, Paolo Filipponi, Thomas Ruch, Nikola Kovacic, Bertrand Guelat, Philippe Piechon, Guanghua Jia, Xi Luo, Junjie Sun, Feng Gao, Xin Gu, Jianghua Zhang, Hai Dong, Thierry Schlama, Nadine Derrien, Thomas Allmendinger, Xiaoquan Lu, Bo Yu, Hongwei Yang, Huijuan Gu, Xuesong Zhang, Huaimin Wang, Yunzhong Li, Pascale Hoehn, Like Chen, Yingtao Tian, Su Xu, Luca Hermann, Berthold Schenkel, Shengqing Ye, Yan Wang, Xingxian Gu, Xufan Wang, Meng Chang, Min Zhongcheng, Jibin Zhao
Publikováno v:
The Journal of organic chemistry. 85(11)
LCZ696 is a novel treatment for patients suffering from heart failure that combines the two active pharmaceutical ingredients sacubitril and valsartan in a single chemical compound. While valsartan is an established drug substance, a new manufacturin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5984c8d356cd451e16b476cf7a210b50
https://pubmed.ncbi.nlm.nih.gov/32412751
https://pubmed.ncbi.nlm.nih.gov/32412751
Autor:
Berthold Schenkel, Xiangguang Tian, Hongwei Yang, Like Chen, Benjamin Martin, Hansjoerg Lehmann, Jutta Polenk
Publikováno v:
Current Opinion in Green and Sustainable Chemistry. 11:27-33
The paper outlines the application of continuous manufacturing to hazardous chemistries, with particular application to early-phase pharmaceutical chemistry. Three case studies are shared with a view to highlighting the factors which render continuou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6130ec8a735ee4a850a042278ebc173f
https://doi.org/10.1016/j.cogsc.2018.03.005
https://doi.org/10.1016/j.cogsc.2018.03.005
Publikováno v:
Organic Process Research & Development. 22:446-456
Diazomethane is an exceptionally versatile C1 building block in organic synthesis. However, reactions involving the use of diazomethane impose significant challenges for safe scale-up. This review aims to highlight the recent developments in processe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97498bcbcf07c92460377e6d19c42c33
https://doi.org/10.1021/acs.oprd.7b00302
https://doi.org/10.1021/acs.oprd.7b00302