Výsledky vyhledávání - "Berta Henriquez"

Akademický článek

PSD95 suppresses dendritic arbor development in mature hippocampal neurons by occluding the clustering of NR2B-NMDA receptors.

Autor: Fernando J Bustos, Lorena Varela-Nallar, Matias Campos, Berta Henriquez, Marnie Phillips, Carlos Opazo, Luis G Aguayo, Martin Montecino, Martha Constantine-Paton, Nibaldo C Inestrosa, Brigitte van Zundert

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e94037 (2014)

Considerable evidence indicates that the NMDA receptor (NMDAR) subunits NR2A and NR2B are critical mediators of synaptic plasticity and dendritogenesis; however, how they differentially regulate these processes is unclear. Here we investigate the rol

Externí odkaz: https://doaj.org/article/51288436b9df4ac6a4cf47d40c73b7ba

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Epigenetic control of the EWS‑FLI1 promoter in Ewing's sarcoma

Autor: Jorge Rodríguez, Alejandra Cañas, C. Montoya, Adriana Rojas, Berta Henriquez, Laura Rey, María José Fernández, D. Troncoso, Olga Moreno

Publikováno v: Oncology Reports

Ewing sarcoma (ES) is a primary bone marrow tumor that very rarely develops in extra‑osseous tissues, such as lung. The hallmark of ES tumors is a translocation between chromosomes 11 and 22, resulting in a fusion protein, commonly referred to as E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc33fb371ff7b590c5c7b5432a80ad95
https://doi.org/10.3892/or.2020.7489

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Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer’s disease mice

Publikováno v: Brain
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Brain, 140, 3252-3268. Oxford University Press

The Dlg4 gene encodes for post-synaptic density protein 95 (PSD95), a major synaptic protein that clusters glutamate receptors and is critical for plasticity. PSD95 levels are diminished in ageing and neurodegenerative disorders, including Alzheimer�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcf35288aa530f463ca33aae315838f
https://doi.org/10.1093/brain/awx272

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Mll-COMPASS complexes mediate H3K4me3 enrichment and transcription of the osteoblast master gene Runx2/p57 in osteoblasts

Autor: Fernando J. Bustos, Andre J. van Wijnen, Gino Nardocci, Gary S. Stein, Jane B. Lian, Tatiana Opazo, Janet L. Stein, Brigitte van Zundert, Miguel L. Allende, Adriana Rojas, Rodrigo Aguilar, Martin Montecino, Berta Henriquez, Hugo Sepulveda

Publikováno v: J Cell Physiol

Expression of Runx2/p57 is a hallmark of the osteoblast-lineage identity. Although several regulators that control the expression of Runx2/p57 during osteoblast-lineage commitment have been identified, the epigenetic mechanisms that sustain this expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b50e7bff96b2e89bde06e5e41fc5818b
https://pubmed.ncbi.nlm.nih.gov/30256410

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Primary lung cancer cell culture from transthoracic needle biopsy samples

Autor: Alejandra Cañas, Juan Andres Mejia, Adriana Rojas, Angélica Herreño, Olga Moreno, Berta Henriquez, Martin Montecino, Laura Rey, María José Fernández

Publikováno v: Cogent Medicine, Vol 5, Iss 1 (2018)

Lung cancer is the leading cause of cancer death in the world. The high mortality rate of this pathology is directly related to its late detection, since its symptoms can be masked by other diseases of lower risk. Although in recent years the number

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d5f0bfe7411e0950b46757b69067d5
https://doi.org/10.1080/2331205x.2018.1503071

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The 1α,25-dihydroxy Vitamin D3 receptor preferentially recruits the coactivator SRC-1 during up-regulation of the osteocalcin gene

Autor: Gary S. Stein, Sergio A. Onate, Janet L. Stein, Andre J. Van Wijnen, Loreto Carvallo, Juan Olate, Jane B. Lian, Berta Henriquez, Martin Montecino

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 103:420-424

Binding of 1alpha,25-dihydroxy Vitamin D3 to the C-terminal domain (LBD) of its receptor (VDR), induces a conformational change that enables interaction of VDR with transcriptional coactivators such as the members of the p160/SRC family or the DRIP (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1332662b5d70c73b7185fb48749a97f5
https://doi.org/10.1016/j.jsbmb.2006.12.022

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Epigenetic Control of the Bone-master Runx2 Gene during Osteoblast-lineage Commitment by the Histone Demethylase JARID1B/KDM5B

Autor: Janet L. Stein, Adriana Rojas, Brigitte van Zundert, Andre J. van Wijnen, Rodrigo Aguilar, Berta Henriquez, Miguel L. Allende, Gary S. Stein, Martin Montecino, Jane B. Lian

Publikováno v: J Biol Chem
Artículos CONICYT
CONICYT Chile
instacron:CONICYT

Transcription factor Runx2 controls bone development and osteoblast differentiation by regulating expression of a significant number of bone-related target genes. Here, we report that transcriptional activation and repression of the Runx2 gene via it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e314341e741ec2f94a4ac441104185b

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Recruitment and subnuclear distribution of the regulatory machinery during 1α,25-dihydroxy vitamin D3-mediated transcriptional upregulation in osteoblasts

Autor: Daniel Moena, Berta Henriquez, Jane B. Lian, Martin Montecino, Paola Merino, Gloria Arriagada, Janet L. Stein, Cinthya Ruiz-Tagle, Gary S. Stein

Publikováno v: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
Artículos CONICYT
CONICYT Chile
instacron:CONICYT

The architectural organization of the genome and regulatory proteins within the nucleus supports gene expression in a physiologically regulated manner. In osteoblastic cells ligand activation induces a nuclear punctate distribution of the 1alpha,25-d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2197a9788cc997ce50bda795b8731899
https://doi.org/10.1016/j.jsbmb.2010.02.013

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Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons

Autor: Fernando J. Bustos, Martin Montecino, Rodrigo Aguilar, Alvaro Becerra, Brigitte van Zundert, Berta Henriquez, Felipe Simon

Publikováno v: Molecular and Cellular Neurosciences
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
MOLECULAR AND CELLULAR NEUROSCIENCE

Polycomb Repressive Complex 2 (PRC2) mediates transcriptional silencing by catalyzing histone H3 lysine 27 trimethylation (H3K27me3), but its role in the maturation of postmitotic mammalian neurons remains largely unknown. We report that the PRC2 par

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95214b301c2520510057f497c2d64f5b
https://pubmed.ncbi.nlm.nih.gov/23932971

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C/EBPβ binds the P1 promoter of the Runx2 gene and up-regulates Runx2 transcription in osteoblastic cells

Autor: Andre J. Van Wijnen, Matias I. Hepp, Hugo Sepulveda, Martin Montecino, Paola Merino, Berta Henriquez, Jane B. Lian, Gary S. Stein, Janet L. Stein

Publikováno v: Journal of Cellular Physiology
Artículos CONICYT
CONICYT Chile
instacron:CONICYT

The Runx2 factor is an essential component of the regulatory mechanisms that control transcription during skeletogenesis. Runx2/p57 expression in osteoblastic cells is controlled by the P1 promoter, which is recognized by key regulators of osteoblast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47149d293ffd5806e22403126f382ca8
https://europepmc.org/articles/PMC3449309/

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