Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Berta Casar"'
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-10 (2024)
Abstract Cancer most frequently develops in self-renewal tissues that are the target of genetic alterations due to mutagens or intrinsic DNA replication errors. Histone γH2AX has a critical role in the cellular DNA repair pathway cascade and contrib
Externí odkaz:
https://doaj.org/article/6af40f575d6b41c5810df30a710f4af9
Autor:
Miguel Angel Merlos Rodrigo, Hana Michalkova, Vladislav Strmiska, Berta Casar, Piero Crespo, Vivian de los Rios, J. Ignacio Casal, Yazan Haddad, Roman Guran, Tomas Eckschlager, Petra Pokorna, Zbynek Heger, Vojtech Adam
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Metallothionein-3 has poorly characterized functions in neuroblastoma. Cisplatin-based chemotherapy is a major regimen to treat neuroblastoma, but its clinical efficacy is limited by chemoresistance. We investigated the impact of human metal
Externí odkaz:
https://doaj.org/article/c380e720965d4d49b73aadef566e6723
Autor:
Miguel Angel Merlos Rodrigo, Berta Casar, Hana Michalkova, Ana Maria Jimenez Jimenez, Zbynek Heger, Vojtech Adam
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
PurposeThe chick chorioallantoic membrane (CAM) assay can provide an alternative versatile, cost-effective, and ethically less controversial in vivo model for reliable screening of drugs. In the presented work, we demonstrate that CAM assay (in ovo a
Externí odkaz:
https://doaj.org/article/cb227be5fe354aacabdcb1816ddbcb0f
Autor:
Berta Casar, Andrew P. Badrock, Iñaki Jiménez, Imanol Arozarena, Paula Colón-Bolea, L. Francisco Lorenzo-Martín, Irene Barinaga-Rementería, Jorge Barriuso, Vincenzo Cappitelli, Daniel J. Donoghue, Xosé R. Bustelo, Adam Hurlstone, Piero Crespo
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
RAS isoforms are associated with the plasma membrane and endomembranes, but how their localization contributes to tumorigenesis is unclear. Here, the authors show that RAS signals from Golgi complex antagonize tumour formation by inducing apoptosis v
Externí odkaz:
https://doaj.org/article/1f3887098b28416d9c9f3a9d72788b25
Autor:
Fani Karagianni, Christina Piperi, Berta Casar, Dalia de la Fuente-Vivas, Rocío García-Gómez, Kyriaki Lampadaki, Vasiliki Pappa, Evangelia Papadavid
Publikováno v:
Cancers, Vol 14, Iss 4, p 1070 (2022)
The combination of Resminostat (HDACi) and Ruxolitinib (JAKi) exerted cytotoxic effects and inhibited proliferation of CTCL cell lines (MyLa, SeAx) in previously published work. A xenograft tumor formation was produced by implanting the MyLa or SeAx
Externí odkaz:
https://doaj.org/article/044908ae2dde4d579320ef660da9f764
Publikováno v:
Biomolecules, Vol 11, Iss 11, p 1554 (2021)
Metastasis is a complex process by which cancer cells escape from the primary tumor to colonize distant organs. RAC1 is a member of the RHO family of small guanosine triphosphatases that plays an important role in cancer migration, invasion, angiogen
Externí odkaz:
https://doaj.org/article/51e13b68bf2940e4a3bc15a599bab654
Autor:
Yaiza García-Ibáñez, Garcilaso Riesco-Eizaguirre, Pilar Santisteban, Berta Casar, Piero Crespo
Publikováno v:
Cancers, Vol 12, Iss 9, p 2588 (2020)
RAS mutations are the second most common genetic alteration in thyroid tumors. However, the extent to which they are associated with the most aggressive phenotypes is still controversial. Regarding their malignancy, the majority of RAS mutant tumors
Externí odkaz:
https://doaj.org/article/4ad1269a87f54448a47a42240d4644d6
Autor:
Piero Crespo, BERTA CASAR
Publikováno v:
Bio-Protocol, Vol 6, Iss 20 (2016)
Metastasis is a complex process that includes several steps: neoplastic progression, angiogenesis, cell migration and invasion, intravasation into nearby blood vessels, survival in the circulatory system, extravasation followed by homing into distant
Externí odkaz:
https://doaj.org/article/b4dcd6fe9fdf4997bdb565d6f0d84d7f
Scaffold coupling: ERK activation by trans-phosphorylation across different scaffold protein species
Autor:
Ana Martín-Vega, Laura Ruiz-Peinado, Rocío García-Gómez, Ana Herrero, Dalia de la Fuente-Vivas, Swetha Parvathaneni, Rubén Caloto, Marta Morante, Alex von Kriegsheim, Xosé R. Bustelo, David B. Sacks, Berta Casar, Piero Crespo
Publikováno v:
Martín-Vega, A, Ruiz-Peinado, L, García-Gómez, R, Herrero, A, de la Fuente-Vivas, D, Parvathaneni, S, Caloto, R, Morante, M, von Kriegsheim, A, R Bustelo, X, B Sacks, D, Casar, B & Crespo, P 2023, ' Scaffold coupling: ERK activation by trans-phosphorylation across different scaffold protein species. ', Science Advances . https://doi.org/10.1126/sciadv.add7969
Resumen del trabajo presentado en el II Congreso Anual de la Red Conexión Cáncer, celebrado en Alicante (España) del 23 al 25 de enero de 2023.
ERK 1/2 proteregulatory proteins like scaffold proteins, that link the components of MAP kinases s
ERK 1/2 proteregulatory proteins like scaffold proteins, that link the components of MAP kinases s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c63c8a143439c0528183ed58d7d619fa
https://hdl.handle.net/20.500.11820/1687b1b2-f437-4754-93cf-4a7ff14f6c4f
https://hdl.handle.net/20.500.11820/1687b1b2-f437-4754-93cf-4a7ff14f6c4f
Autor:
Alejandro A. Gru, José P. Vaqué, Marta Gut, M. Rodriguez, Nuria García-Díaz, Ignacio Varela, Miguel A. Piris, María Carmen González-Vela, José Luis Rodríguez-Peralto, Ivo Gut, Ruth Alonso-Alonso, Laura Quevedo, Anna Esteve-Codina, Berta Casar, Fulgencio Ruso-Julve, Pablo L. Ortiz-Romero
Developing mechanistic rationales can improve the clinical management of cutaneous T-cell lymphomas. There is considerable genetic and biological evidence of a malignant network of signaling mechanisms, highly influenced by deregulated TCR/PLCγ1 act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167c34340b0fe031ba720b4370e3a198
http://hdl.handle.net/10261/285078
http://hdl.handle.net/10261/285078