Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Berta Strulovici"'
Autor:
Carlo Toniatti, Aimee L. Jackson, Michele A. Cleary, Erica Stec, Stacey Szymanski, Peter S. Linsley, Francesca Santini, Steven R. Bartz, Marc Ferrer, Berta Strulovici, Michael Carleton, Rachel H. V. Needham, Anthony Palmieri, Louis Locco
Publikováno v:
SLAS Discovery. 17:1316-1328
Gene silencing by RNA interference has become a powerful tool to help identify genes that regulate biological processes. However, the complexity of the biology probed and the incomplete validation of the reagents used make it difficult to interpret t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb291a7cc23c382aa0baeb9b1fdb64ad
https://doi.org/10.1177/1087057112453071
https://doi.org/10.1177/1087057112453071
Autor:
Berta Strulovici, Raul Lacson, Anthony Kreamer, Francesca Santini, Marc Ferrer, Jason Cassaday, Donna McLaren, Edward Hudak, Richard Peltier, Ignacio Munoz-Sanjuan, David A. Ross, Yaping Liu
Publikováno v:
SLAS Discovery. 14:319-329
Adult mouse subventricular zone (SVZ) neural stem/progenitor cells are multipotent self-renewing cells that retain the capacity to generate the major cell types of the central nervous system in vitro and in vivo. The relative ease of expanding SVZ ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5361ccd1f6aa78eb64fa34fff6a6185
https://doi.org/10.1177/1087057109332596
https://doi.org/10.1177/1087057109332596
Autor:
Adam Gates, Erica Stec, Daniel J. Holder, Yingxue C. Liu, Marc Ferrer, Joseph F. Heyse, Berta Strulovici, Min Xu, Pei Fen Kuan, Xiaohua Douglas Zhang, Priya Kunapuli, Shane D. Marine, Amy S. Espeseth, Xiaohua Shu
Publikováno v:
Nucleic Acids Research
RNA interference (RNAi) is a modality in which small double-stranded RNA molecules (siRNAs) designed to lead to the degradation of specific mRNAs are introduced into cells or organisms. siRNA libraries have been developed in which siRNAs targeting vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9853d0dfc74ccaa4f72c217730ddaf46
https://doi.org/10.1093/nar/gkn435
https://doi.org/10.1093/nar/gkn435
Publikováno v:
ASSAY and Drug Development Technologies. 6:327-337
Members of the superfamily of seven transmembrane receptors, known as G protein-coupled receptors (GPCRs), are important targets for many therapeutic areas in drug discovery. A homogeneous guanosine 5'-O-(3-[(35)S]thio)triphosphate ([(35)S]GTPgammaS)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2697b27b209a185a2c655b0dea62ca4
https://doi.org/10.1089/adt.2007.113
https://doi.org/10.1089/adt.2007.113
Integrating Experimental and Analytic Approaches to Improve Data Quality in Genome-wide RNAi Screens
Autor:
Eric M. Stec, Eric N. Johnson, Jayne Chin, Adam Gates, Dan Holder, Lyndon J. Mitnaul, Berta Strulovici, Marc Ferrer, Jenny Tian, Priya Kunapuli, Joseph F. Heyse, Shane Marine, Xiaohua Douglas Zhang, Amy S. Espeseth
Publikováno v:
SLAS Discovery. 13:378-389
RNA interference (RNAi) not only plays an important role in drug discovery but can also be developed directly into drugs. RNAi high-throughput screening (HTS) biotechnology allows us to conduct genome-wide RNAi research. A central challenge in genome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ad15756491d54edc34ea617a525899
https://doi.org/10.1177/1087057108317145
https://doi.org/10.1177/1087057108317145
Autor:
Justin Murray, Denise K. Young, James Feasby, Richard Peltier, Eric N. Johnson, Berta Strulovici, Amita Patel, Bethel V. Sharma, Stacey Szymanski, Kevin W. Huff, Alison Rush
Publikováno v:
JALA: Journal of the Association for Laboratory Automation. 13:136-144
As the drug discovery process evolves and demands more challenging and relevant assays, we have experienced a recent and significant escalation in the number of cell-based high-throughput assays for both small molecule and target identification scree
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3e862ecf11f06455909f655f3b675b1
https://doi.org/10.1016/j.jala.2007.12.010
https://doi.org/10.1016/j.jala.2007.12.010
Autor:
Maria L. Garcia, Berta Strulovici, Kelli Solly, Jason Cassaday, Laszlo Kiss, John P. Felix, Marc Ferrer
Publikováno v:
ASSAY and Drug Development Technologies. 6:225-234
The K(ir) family of potassium-selective ion channels is characterized by their inward (anomalous) rectifying current-voltage relationship. K(ir) channels are widely expressed in mammalian cells and through their role in regulation of the cell membran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c4b1801d70ab951334de8cc7654b11
https://doi.org/10.1089/adt.2008.123
https://doi.org/10.1089/adt.2008.123
Autor:
Louis Locco, Pei Fen Kuan, Steven R. Bartz, Anthony Kreamer, Xiaohua Douglas Zhang, Namjin Chung, Marc Ferrer, Berta Strulovici, Peter S. Linsley
Publikováno v:
SLAS Discovery. 13:149-158
High-throughput screening (HTS) of large-scale RNA interference (RNAi) libraries has become an increasingly popular method of functional genomics in recent years. Cell-based assays used for RNAi screening often produce small dynamic ranges and signif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42a6e54fe2594d0ed8e22c6ee1dda83f
https://doi.org/10.1177/1087057107312035
https://doi.org/10.1177/1087057107312035
Autor:
Steven R. Bartz, Peter S. Linsley, Berta Strulovici, Namjin Chung, Louis Locco, Kevin W. Huff, Marc Ferrer
Publikováno v:
SLAS Discovery. 13:142-148
RNA interference (RNAi), combined with the availability of genome sequences, provides an unprecedented opportunity for the massive and parallel investigations of gene function. Small interfering RNA (siRNA) represents a popular and quick approach of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f35e8fd6c724b891fd94f6ce38948f
https://doi.org/10.1177/1087057107312032
https://doi.org/10.1177/1087057107312032
Autor:
Suzanne S. Eveland, Paul Zuck, Sheryl A. Hyland, Wesley Tanaka, Marc Ferrer, Berta Strulovici, Omar F Laterza, Ying Chen, Matt S. Anderson, Qiu Guo, John A. Wagner, Samuel D. Wright, Laurence B. Peterson, Gregory O'Donnell, Carl P. Sparrow, Denise P. Milot, Sylvie Jezequel-Sur, Deborah Hilliard
Publikováno v:
Analytical Biochemistry. 368:239-249
Cholesteryl ester transfer protein (CETP) is a serum component responsible for both cholesteryl ester and triglyceride trafficking between high-density lipoprotein (HDL) and the apolipoprotein B (apoB)-containing very low-density lipoprotein (VLDL) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::123d05e7f98c3e31163cda0f9a5ae4c8
https://doi.org/10.1016/j.ab.2007.06.003
https://doi.org/10.1016/j.ab.2007.06.003