Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Bert-Jan Baas"'
Autor:
Jan-Ytzen van der Meer, Harshwardhan Poddar, Bert-Jan Baas, Yufeng Miao, Mehran Rahimi, Andreas Kunzendorf, Ronald van Merkerk, Pieter G. Tepper, Edzard M. Geertsema, Andy-Mark W. H. Thunnissen, Wim J. Quax, Gerrit J. Poelarends
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
The Michael-type addition reaction is used for carbon-carbon bond formation; however biocatalytic methods for this reaction are rare. Here, the authors generate and exploit mutability landscapes of 4-oxalocrotonate tautomerase to direct the redesign
Externí odkaz:
https://doaj.org/article/9cfd7194e093495a81ae07646995d9a2
Publikováno v:
FEBS Open Bio, Vol 4, Iss C, Pp 651-658 (2014)
4-Oxalocrotonate tautomerase (4-OT) catalyzes the enol-keto tautomerization of 2-hydroxymuconate, utilizing its N-terminal proline (Pro-1) as general base catalyst. Substituting Pro-1 with bulky or charged residues will result in poor or no post-tran
Externí odkaz:
https://doaj.org/article/cd60daf32ad04a45afd0ee320d364529
Autor:
Emily B. Lancaster, Wanjie Yang, William H. Johnson, Bert-Jan Baas, Yan Jessie Zhang, Christian P. Whitman
Publikováno v:
Biochemistry. 61:1136-1148
Autor:
Christian P. Whitman, Bert-Jan Baas, Tamer S. Kaoud, Patricia C. Babbitt, Kaci Erwin, R. Yvette Moreno, Jake LeVieux, Marieke de Ruijter, Yan Jessie Zhang, William H. Johnson, Emily B. Lancaster, Brenda P. Medellin
Publikováno v:
Biochemistry
The tautomerase superfamily (TSF) is a collection of enzymes and proteins that share a simple β-α-β structural scaffold. Most members are constructed from a single-core β-α-β motif or two consecutively fused β-α-β motifs in which the N-termi
Autor:
Rebecca Davidson, Patricia C. Babbitt, Tamer S. Kaoud, Christian P. Whitman, Bert-Jan Baas, Jake LeVieux, Yan Jessie Zhang
Publikováno v:
Archives of Biochemistry and Biophysics. 636:50-56
A Pseudomonas sp. UW4 protein (UniProt K9NIA5) of unknown function was identified as similar to 4-oxalocrotonate tautomerase (4-OT)-like and cis-3-chloroacrylic acid dehalogenase (cis-CaaD)-like subgroups of the tautomerase superfamily (TSF). This pr
Autor:
Patricia C. Babbitt, Jake LeVieux, Eyal Akiva, Yan Jessie Zhang, Rebecca Davidson, Collin R. Pullara, Christian P. Whitman, Bert-Jan Baas, Benjamin J. Polacco, Gemma L. Holliday
Publikováno v:
The Journal of Biological Chemistry
The tautomerase superfamily (TSF) consists of more than 11,000 nonredundant sequences present throughout the biosphere. Characterized members have attracted much attention because of the unusual and key catalytic role of an N-terminal proline. These
Autor:
Yan Jessie Zhang, Brenda P. Medellin, Patricia C. Babbitt, Marieke de Ruijter, Christian P. Whitman, Bert-Jan Baas, Jake LeVieux, Eyal Akiva, Shoshana D. Brown
Publikováno v:
Biochemistry. 58(22)
A 4-oxalocrotonate tautomerase (4-OT) trimer has been isolated from Burkholderia lata, and a kinetic, mechanistic, and structural analysis has been performed. The enzyme is the third described oligomer state for 4-OT along with a homo- and heterohexa
Autor:
Bert-Jan Baas, Harshwardhan Poddar, Jan-Ytzen van der Meer, Gerrit J. Poelarends, Edzard M. Geertsema, Mehran Rahimi
Publikováno v:
ChemBioChem, 17(13), 1225-1228. WILEY-V C H VERLAG GMBH
The enzyme 4-oxalocrotonate tautomerase (4-OT), which catalyzes enol-keto tautomerization as part of a degradative pathway for aromatic hydrocarbons, promiscuously catalyzes various carbon-carbon bond-forming reactions. These include the aldol conden
Autor:
Pieter G. Tepper, Edzard M. Geertsema, Wim J. Quax, Andreas Kunzendorf, Mehran Rahimi, Yufeng Miao, Bert-Jan Baas, Jan-Ytzen van der Meer, Andy-Mark W. H. Thunnissen, Gerrit J. Poelarends, Ronald van Merkerk, Harshwardhan Poddar
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Nature Communications
Nature Communications, 7:10911. Nature Publishing Group
Nature Communications
Nature Communications, 7:10911. Nature Publishing Group
The Michael-type addition reaction is widely used in organic synthesis for carbon–carbon bond formation. However, biocatalytic methodologies for this type of reaction are scarce, which is related to the fact that enzymes naturally catalysing carbon
Autor:
Johan te Biesebeek, Frank J. Dekker, Stephanie Thee, Nikolaos Eleftheriadis, Bert-Jan Baas, Petra E van der Wouden
Publikováno v:
European Journal of Medicinal Chemistry, 94, 265-275. ELSEVIER MASSON, CORPORATION OFFICE
Lipoxygenases metabolize polyunsaturated fatty acids into signalling molecules such as leukotrienes and lipoxins. 15-lipoxygenase-1 (15-LOX-1) is an important mammalian lipoxygenase and plays a crucial regulatory role in several respiratory diseases