Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Bert N. La Du"'
Autor:
Dragomir I. Draganov, John F. Teiber, Audrey Speelman, Yoichi Osawa, Roger Sunahara, Bert N. La Du
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 6, Pp 1239-1247 (2005)
The paraoxonase (PON) gene family in humans has three members, PON1, PON2, and PON3. Their physiological role(s) and natural substrates are uncertain. We developed a baculovirus-mediated expression system, suitable for all three human PONs, and optim
Externí odkaz:
https://doaj.org/article/4245723222124ec6a8c810c3b3c3c0ab
Publikováno v:
Journal of Lipid Research, Vol 45, Iss 12, Pp 2260-2268 (2004)
Purified serum paraoxonase (PON1) had been shown to attenuate the oxidation of LDL in vitro. We critically reevaluated the antioxidant properties of serum PON1 in the in vitro assays initiated with copper or the free radical generator 2,2′-azobis-2
Externí odkaz:
https://doaj.org/article/f7d0a3a46bb1470ab16394753521b5f8
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 6, Pp 951-958 (2001)
Human paraoxonase 1 (hPON1) is a lipid-associated enzyme transported on HDL. There is considerable interest in hPON1 because of its putative antioxidative/antiatherogenic properties. We have created a recombinant baculovirus (BV) to generate hPON1A i
Externí odkaz:
https://doaj.org/article/6c684238d6554cbe929dc74be9122b65
Autor:
Bert N. La Du, Yoichi Osawa, Audrey Speelman, Roger K. Sunahara, John F. Teiber, Dragomir I. Draganov
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 6, Pp 1239-1247 (2005)
The paraoxonase (PON) gene family in humans has three members, PON1, PON2, and PON3. Their physiological role(s) and natural substrates are uncertain. We developed a baculovirus-mediated expression system, suitable for all three human PONs, and optim
Autor:
Bert N. La Du, Charles L. Bisgaier, Mira Rosenblat, Michael Aviram, Catherine E. Watson, Dragomir I. Draganov
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 23:468-474
Objective— To determine whether paraoxonases (PONs) are expressed in macrophages and to analyze the oxidative stress effect on their expression and activities. Methods and Results— We demonstrated the presence (mRNA, protein, activity) of PON2 an
Autor:
Masakiyo Hosokawa, Palmer Taylor, William F. Bosron, Tetsuo Satoh, Bert N. La Du, Sonal P. Sanghani
Publikováno v:
Drug Metabolism and Disposition. 30:488-493
This article reports on a symposium sponsored by the American Society for Pharmacology and Experimental Therapeutics and held at the April 2001 Experimental Biology meeting. Current developments in molecular-based studies into the structure and funct
Publikováno v:
Journal of Lipid Research, Vol 42, Iss 6, Pp 951-958 (2001)
Human paraoxonase 1 (hPON1) is a lipid-associated enzyme transported on HDL. There is considerable interest in hPON1 because of its putative antioxidative/antiatherogenic properties. We have created a recombinant baculovirus (BV) to generate hPON1A i
Autor:
Catherine E. Watson, Charles L. Bisgaier, Bert N. La Du, Scott S. Billecke, Dragomir I. Draganov
Publikováno v:
Pharmacogenetics. 11:123-134
Serum paraoxonase (PON1) is a high-density lipoprotein (HDL)-associated enzyme that hydrolyses aromatic esters, organophosphates and lactones and can protect low-density lipoprotein (LDL) against oxidation. These properties are influenced by a well-c
Autor:
Graham F. Maguire, Arnis Kuksis, Bert N. La Du, Andrew Emili, Dragomir I. Draganov, Amir Ravandi, Philip W. Connelly, Zakaria Ahmed
Publikováno v:
Journal of Biological Chemistry. 276:24473-24481
High density lipoprotein (HDL) is rich in polyunsaturated phospholipids that are sensitive to oxidation. However, the effect of apolipoprotein A-I and paraoxonase-1 (PON-1) on phosphatidylcholine oxidation products has not been identified. We subject