Výsledky vyhledávání - "Bert Kazemier"

Akademický článek

Broad Epitope Coverage of Therapeutic Multi-Antibody Combinations Targeting SARS-CoV-2 Boosts In Vivo Protection and Neutralization Potency to Corner an Immune-Evading Virus

Publikováno v: Biomedicines, Vol 12, Iss 3, p 642 (2024)

Therapeutic antibodies (Abs) which act on a broader range of epitopes may provide more durable protection against the genetic drift of a target, typical of viruses or tumors. When these Abs exist concurrently on the targeted antigen, several mechanis

Externí odkaz: https://doaj.org/article/459ec3803da944938bf01fc46431f58a

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Implementation of High Throughput Screening on iPS cells

Autor: Bert Kazemier

Pivot Park Screening Centre is a CRO specialized in high throughput screening and operates as the beating heart of the European Lead Factory (ELF). ELF is a pan-European platform for drug discovery, supported by IMI, which was launched 3 years ago to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e79990d8eff2f2d142343a25b0359e46

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X-ray Structures of Progesterone Receptor Ligand Binding Domain in Its Agonist State Reveal Differing Mechanisms for Mixed Profiles of 11β-Substituted Steroids

Autor: Marcel van Duin, Rita Azevedo, Hans Hamersma, Diep Vu-Pham, Arthur Oubrie, Scott J. Lusher, Rolien Bosch, Bert Kazemier, Hans C.A. Raaijmakers, Jacob de Vlieg, Koen J. Dechering, Ross McGuire

Publikováno v: Journal of Biological Chemistry, 287, 20333-20343
Journal of Biological Chemistry, 287, 24, pp. 20333-20343

Contains fulltext : 103894.pdf (Publisher’s version ) (Open Access) We present here the x-ray structures of the progesterone receptor (PR) in complex with two mixed profile PR modulators whose functional activity results from two differing molecula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5603237fee702c88c44068b45f204787
https://doi.org/10.1074/jbc.m111.308403

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High-resolution crystal structures of factor XIa coagulation factor in complex with nonbasic high-affinity synthetic inhibitors

Autor: Anja Jestel, Stephan Krapp, Maureen Dempster, Xavier Fradera, Susanna Nagel, Emma Carswell, Andrew J. Cooke, William Hamilton, Bert Kazemier, Arthur Oubrie

Publikováno v: Acta Crystallographica Section F Structural Biology and Crystallization Communications. 68:404-408

Factor XI (FXI) is a key enzyme in the coagulation pathway and an attractive target for the development of anticoagulant drugs. A small number of high-resolution crystal structures of FXIa in complex with small synthetic inhibitors have been publishe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbb9445d69885ca908101db6115fb6f4
https://doi.org/10.1107/s1744309112009037

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Vernier zone residue 4 of mouse subgroup II kappa light chains is a critical determinant for antigen recognition

Autor: Piet J. Boender, Hans J. W. de Haard, Bert Kazemier, Jan-Willem Arends, Bob van Gemen, P. Oudshoorn, Arie van der Bent

Publikováno v: Immunotechnology 4 (1999) 3-4
Immunotechnology, 4(3-4), 203-215

Background: During the conversion of murine monoclonal antibodies directed against the human chorionic gonadotropin (hCG) into bacterially expressed single chain fragments (scFv), we found a major reduction of binding activity upon introduction of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9caa511812a0391d146b1874c4669946
https://doi.org/10.1016/s1380-2933(98)00021-9

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Selection of human anti-human immunodeficiency virus type 1 envelope single-chain antibodies from a peripheral blood cell-based phage repertoire

Autor: Marck J. M. Koolen, Piet J. Boender, B. van Gemen, Bert Kazemier, G. van der Groen, Hennie R. Hoogenboom, J. J. W. De Haard, P. Oudshoorn, Jan-Willem Arends

Publikováno v: Journal of General Virology. 79:2883-2894

Monoclonal antibodies play an important role in the development of diagnostic assays. Instead of using hybridoma technology to isolate human immunodeficiency virus type 1-specific antibodies, a phage-displayed antibody library was generated from a sm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c147b08365a88a0242b2ff9c0e6d3104
https://doi.org/10.1099/0022-1317-79-12-2883

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Selection of Recombinant, Library-Derived Antibody Fragments against p24 for Human Immunodeficiency Virus Type 1 Diagnostics

Autor: Marck J. M. Koolen, Hans J. W. de Haard, Hennie R. Hoogenboom, Bob van Gemen, Liekle J. Nijholt, Jan-Willem Arends, Rob H. Meloen, Bert Kazemier

Publikováno v: Clinical Diagnostic Laboratory Immunology. 5:636-644

By application of combinatorial library technology, we generated the first recombinant antibody fragments directed against the major capsid protein p24 of human immunodeficiency virus type 1 (HIV-1). A library of single-chain Fv fragments (scFvs) was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26565298ef0a627fa66bec6f53f249f9
https://doi.org/10.1128/cdli.5.5.636-644.1998

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Novel ATP competitive MK2 inhibitors with potent biochemical and cell-based activity throughout the series

Autor: Arthur Oubrie, Carsten Schultz-Fademrecht, Vera de Kimpe, Bas van de Kar, Tjeerd Barf, Bert Kazemier, Niels Hoogenboom, Rianne Goorden, Judith Borsboom, Edwin de Zwart, Allard Kaptein, Michiel Scheffers, Jos Lommerse, Jeroen A.D.M. de Roos, Ruud van der Heijden, Maaike van Hoek

Publikováno v: Bioorganicmedicinal chemistry letters. 22(1)

Optimization of our previously described pyrrolopiperidone series led to the identification of a new benzamide sub-series, which exhibits consistently high potency in biochemical and cell-based assays throughout the series. Strong inhibition of LPS-i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f7a874ec708632ed3e0fca030302d8
https://pubmed.ncbi.nlm.nih.gov/22119462

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Discovery of selective and orally available spiro-3-piperidyl ATP-competitive MK2 inhibitors

Publikováno v: Bioorganicmedicinal chemistry letters. 21(12)

The identification of a potent, selective, and orally available MK2 inhibitor series is described. The initial absence of oral bioavailability was successfully tackled by moving the basic nitrogen of the spiro-4-piperidyl moiety towards the electron-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f22fbd250c5e4013286b26a2ff642b
https://pubmed.ncbi.nlm.nih.gov/21565498

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