Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Bert J C, Janssen"'
Autor:
Christos Gogou, J. Wouter Beugelink, Cátia P. Frias, Leanid Kresik, Natalia Jaroszynska, Uwe Drescher, Bert J. C. Janssen, Robert Hindges, Dimphna H. Meijer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Neuronal network formation is facilitated by recognition between synaptic cell adhesion molecules at the cell surface. Alternative splicing of cell adhesion molecules provides additional specificity in forming neuronal connections. For the t
Externí odkaz:
https://doaj.org/article/7755a7b835704dd8869e2fbd3bcc9be6
Autor:
Lucas M. P. Chataigner, Christos Gogou, Maurits A. den Boer, Cátia P. Frias, Dominique M. E. Thies-Weesie, Joke C. M. Granneman, Albert J. R. Heck, Dimphna H. Meijer, Bert J. C. Janssen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
In this work the authors show how a combination of glycosylations, rigid and flexible parts within neurofascin 155 and contactin 1 define a 7.4 nm distance at the myelin-axon interface and allow bridging of three-fold larger distances in the synapse.
Externí odkaz:
https://doaj.org/article/513723d5ffb7423c95683e8e1a05d211
Autor:
Matthieu R. Zeronian, Sofia Doulkeridou, Paul M. P. van Bergen en Henegouwen, Bert J. C. Janssen
Publikováno v:
BMC Molecular and Cell Biology, Vol 23, Iss 1, Pp 1-10 (2022)
Abstract Background The epidermal growth factor receptor (EGFR) is involved in various developmental processes, and alterations of its extracellular segment are associated with several types of cancers, in particular glioblastoma multiforme (GBM). Th
Externí odkaz:
https://doaj.org/article/97e603dd6d3c4ad188f414b157bf599d
Publikováno v:
BMC Molecular and Cell Biology, Vol 20, Iss 1, Pp 1-15 (2019)
Abstract Background Olfactomedin-1 (Olfm1; also known as Noelin or Pancortin) is a highly-expressed secreted brain and retina protein and its four isoforms have different roles in nervous system development and function. Structural studies showed tha
Externí odkaz:
https://doaj.org/article/e4c38507be8b460d94ef7e5fbfbe5896
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Type-I transmembrane proteins represent a large group of 1,412 proteins in humans with a multitude of functions in cells and tissues. They are characterized by an extracellular, or luminal, N-terminus followed by a single transmembrane helix and a cy
Externí odkaz:
https://doaj.org/article/3939649fae2e4a37bdc8f156f7725dbe
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
The Sortilin-related CNS-expressed receptor 2 (SorCS2)–proneurotrophin signaling system regulates neuronal plasticity and its dysfunction is linked to schizophrenia. Here the authors present the structures of the SorCS2 ectodomain alone and in comp
Externí odkaz:
https://doaj.org/article/a272131e31ee4e99a1f0ca5d3e9dd5cb
Autor:
Verity A. Jackson, Dimphna H. Meijer, Maria Carrasquero, Laura S. van Bezouwen, Edward D. Lowe, Colin Kleanthous, Bert J. C. Janssen, Elena Seiradake
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Teneurins are cell-cell adhesion receptors that evolved through horizontal gene transfer in which a bacterial YD-repeat protein fused to a eukaryotic receptor. Here the authors present crystallographic and cryo-EM structures of two Teneurins, reveali
Externí odkaz:
https://doaj.org/article/6e704646bfad422d89f023858d91ce18
Autor:
Xiangjie Su, Mercedes Ramírez-Escudero, Feilong Sun, Joep B. van den Dikkenberg, Mies J. van Steenbergen, Roland J. Pieters, Bert J. C. Janssen, Peter M. van Hasselt, Wim E. Hennink, Cornelus F. van Nostrum
Publikováno v:
Pharmaceutics, Vol 13, Iss 12, p 2022 (2021)
The aim of this study was to get insight into the internalization and transport of PEGylat-ed mixed micelles loaded by vitamin K, as mediated by Scavenger Receptor B1 (SR-B1) that is abundantly expressed by intestinal epithelium cells as well as by d
Externí odkaz:
https://doaj.org/article/2931ba0aee4f41da9a65ccb15016fa44
Autor:
Nadia Leloup, Philip Lössl, Dimphna H. Meijer, Martha Brennich, Albert J. R. Heck, Dominique M. E. Thies-Weesie, Bert J. C. Janssen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Sortilin is an endocytosis receptor with a luminal β-propeller domain. Here the authors present the structures of the β-propeller domain at neutral and acidic pH, which reveal that sortilin dimerises and undergoes conformational changes at low pH a
Externí odkaz:
https://doaj.org/article/6012de2c7ca2445a89156e52dab21cee
Autor:
Matti F. Pronker, Suzanne Lemstra, Joost Snijder, Albert J. R. Heck, Dominique M. E. Thies-Weesie, R. Jeroen Pasterkamp, Bert J. C. Janssen
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Myelin-associated glycoprotein (MAG) maintains myelin-axon spacing. Here, the authors report the crystal structures of the MAG full ectodomain in complex with oligosaccharide, and use additional assays to provide insights into the mechanism of MAG-me
Externí odkaz:
https://doaj.org/article/47da9cf46c964aaaa66b8ca1a8ddde26