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Autor:
Ladan Khodaparast, Laleh Khodaparast, Guiqin Wu, Emiel Michiels, Rodrigo Gallardo, Bert Houben, Teresa Garcia, Matthias De Vleeschouwer, Meine Ramakers, Hannah Wilkinson, Ramon Duran-Romaña, Johan Van Eldere, Frederic Rousseau, Joost Schymkowitz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract There is an arms race between beta-lactam antibiotics development and co-evolving beta-lactamases, which provide resistance by breaking down beta-lactam rings. We have observed that certain beta-lactamases tend to aggregate, which persists t
Externí odkaz:
https://doaj.org/article/577fe276aea04bb88f22a8e1a4973c8a
Autor:
Thanh T. Hoang, Yunsung Lee, Daniel L. McCartney, Elin T.G. Kersten, Christian M. Page, Paige M. Hulls, Mikyeong Lee, Rosie M. Walker, Charles E. Breeze, Brian D. Bennett, Adam B. Burkholder, James Ward, Anne Lise Brantsæter, Ida H. Caspersen, Alison A. Motsinger-Reif, Marie Richards, Julie D. White, Shanshan Zhao, Rebecca C. Richmond, Maria C. Magnus, Gerard H. Koppelman, Kathryn L. Evans, Riccardo E. Marioni, Siri E. Håberg, Stephanie J. London, Bastiaan Heijmans, Peter ’t Hoen, Joyce van Meurs, Rick Jansen, Lude Franke, Dorret Boomsma, René Pool, Jenny van Dongen, Jouke Hottenga, Marleen van Greevenbroek, Coen Stehouwer, Carla van der Kallen, Casper Schalkwijk, Cisca Wijmenga, Sasha Zhernakova, Ettje Tigchelaar, P. Eline Slagboom, Marian Beekman, Joris Deelen, Diana Van Heemst, Jan Veldink, Leonard van den Berg, Cornelia van Duijn, Bert Hofman, Aaron Isaacs, André Uitterlinden, P. Mila Jhamai, Michael Verbiest, H. Eka Suchiman, Marijn Verkerk, Ruud van der Breggen, Jeroen van Rooij, Nico Lakenberg, Hailiang Mei, Maarten van Iterson, Michiel van Galen, Jan Bot, Dasha Zhernakova, Peter van ‘t Hof, Patrick Deelen, Irene Nooren, Matthijs Moed, Martijn Vermaat, René Luijk, Marc Bonder, Freerk van Dijk, Wibowo Arindrarto, Szymon Kielbasa, Morris Swertz, Erik van Zwet
Publikováno v:
EBioMedicine, Vol 100, Iss , Pp 104956- (2024)
Summary: Background: Smoking impacts DNA methylation, but data are lacking on smoking-related differential methylation by sex or dietary intake, recent smoking cessation (
Externí odkaz:
https://doaj.org/article/3985b627485b4ff999b2ec073dfaf4e4
Autor:
Athina Keramidioti, Sandra Schneid, Christina Busse, Christoph Cramer von Laue, Bianca Bertulat, Willi Salvenmoser, Martin Hess, Olga Alexandrova, Kristine M Glauber, Robert E Steele, Bert Hobmayer, Thomas W Holstein, Charles N David
Publikováno v:
eLife, Vol 12 (2024)
The Hydra nervous system is the paradigm of a ‘simple nerve net’. Nerve cells in Hydra, as in many cnidarian polyps, are organized in a nerve net extending throughout the body column. This nerve net is required for control of spontaneous behavior
Externí odkaz:
https://doaj.org/article/9bd12375e7f144db8c94fd9959316d7a
Autor:
Luis Gutierrez, Beth Polidoro, David Obura, Francoise Cabada-Blanco, Christi Linardich, Emma Pettersson, Paul Pearce-Kelly, Krista Kemppinen, Juan Jose Alvarado, Lorenzo Alvarez-Filip, Anastazia Banaszak, Pilar Casado de Amezua, James Crabbe, Aldo Croquer, Joshua Feingold, Elizabeth Goergen, Stefano Goffredo, Bert Hoeksema, Danwei Huang, Emma Kennedy, Diego Kersting, Marcelo Kitahara, Petar Kružić, Margaret Miller, Flavia Nunes, Juan Pablo Quimbayo, Andrea Rivera-Sosa, Rosa Rodríguez-Martínez, Nadia Santodomingo, Michael Sweet, Mark Vermeij, Estrella Villamizar, Greta Aeby, Khatija Alliji, Daniel Bayley, Elena Couce, Benjamin Cowburn, C Isabel Nuñez Lendo, Sean Porter, Kaveh Samimi-Namin, Tom Shlesinger, Bryan Wilson
Publikováno v:
PLoS ONE, Vol 19, Iss 11, p e0309354 (2024)
Atlantic reef-building corals and coral reefs continue to experience extensive decline due to increased stressors related to climate change, disease, pollution, and numerous anthropogenic threats. To understand the impact of ocean warming and reef lo
Externí odkaz:
https://doaj.org/article/6a63c1b7488743878ab7ac8649c8d971
Autor:
Soo Downe, Ank de Jonge, Pim P Valentijn, Suzanne Thompson, Hester Rippen, Corine J M Verhoeven, Jolanda Liebregts, Bahareh Goodarzi, Jan Jaap Erwich, George Burchell, Ronald Batenburg, Eline F de Vries, Irene de Graaf, Puck van Heemstra, Jeroen Struijs, Susanne Zuidhof, Inge Boesveld, Anouk Kaiser, Mirjam Fransen, Durk Berks, Pauline Haga, Katarzyna Burzynska, Joland Vermolen, Lucienne Bakker, Mariëtte Hoogsteder, Lillian Peters, Conny Vreugdehil, Aimée Sparendam-Bruijnincx, Betty de Vries, Elle Struijf, Lillianne van der Velde, Bert Horlings, Marianne Nieuwenhuijze, Marc Roosenboom, Simone Plaizier
Publikováno v:
BMJ Open, Vol 14, Iss 1 (2024)
Introduction Integrated care is seen as an enabling strategy in organising healthcare to improve quality, finances, personnel and sustainability. Developments in the organisation of maternity care follow this trend. The way care is organised should s
Externí odkaz:
https://doaj.org/article/b8c5fc835c7b4132b404d4e4dcf041c4
Autor:
Toon Peeters, Bert Houben, Peter Cools, Yati Thys, Valentino D'Onofrio, Sandrina Martens, Martin Jaeger, Marije Doppenberg-Oosting, Mihai G. Netea, Inge C. Gyssens
Publikováno v:
Heliyon, Vol 9, Iss 4, Pp e15131- (2023)
Purpose: Acute appendicitis is a common abdominal emergency worldwide. This study aimed at characterizing environmental risk factors influencing the development and severity of acute appendicitis. Methods: Patients from a Belgian acute appendicitis c
Externí odkaz:
https://doaj.org/article/72a231b6c2fc44cc82a8bf01ed69647d
Autor:
Elizabeth A. Linton, J. B. Dyck, Brendan P. Glynn, Thomas Gfroerer, Daniel L. Azarnoff, Steven L. Shafer, Ronald Goldblum, Bert Ho, Martin S. Angst
Publikováno v:
Clinical Pharmacology & Therapeutics. 64:499-510
Objective Two clinical trials investigated the pharmacokinetics of human corticotropin-releasing factor (hCRF), resulting cortisol release, and associated hemodynamic changes. Methods In a 3 × 3 Latin square design, subjects were randomized to recei
Autor:
Emiel Michiels, Kenny Roose, Rodrigo Gallardo, Ladan Khodaparast, Laleh Khodaparast, Rob van der Kant, Maxime Siemons, Bert Houben, Meine Ramakers, Hannah Wilkinson, Patricia Guerreiro, Nikolaos Louros, Suzanne J. F. Kaptein, Lorena Itatí Ibañez, Anouk Smet, Pieter Baatsen, Shu Liu, Ina Vorberg, Guy Bormans, Johan Neyts, Xavier Saelens, Frederic Rousseau, Joost Schymkowitz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/c25558682e604351be0ae8e8c8234335
Autor:
Marion Lechable, Xuechen Tang, Stefan Siebert, Angelika Feldbacher, Monica L. Fernández-Quintero, Kathrin Breuker, Celina E. Juliano, Klaus R. Liedl, Bert Hobmayer, Markus Hartl
Publikováno v:
Cells, Vol 12, Iss 9, p 1265 (2023)
The proto-oncogene myc has been intensively studied primarily in vertebrate cell culture systems. Myc transcription factors control fundamental cellular processes such as cell proliferation, cell cycle control and stem cell maintenance. Myc interacts
Externí odkaz:
https://doaj.org/article/1b7c8b398acb43f889246597f843760b