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Autor:
Elizabeth A. Linton, J. B. Dyck, Brendan P. Glynn, Thomas Gfroerer, Daniel L. Azarnoff, Steven L. Shafer, Ronald Goldblum, Bert Ho, Martin S. Angst
Publikováno v:
Clinical Pharmacology & Therapeutics. 64:499-510
Objective Two clinical trials investigated the pharmacokinetics of human corticotropin-releasing factor (hCRF), resulting cortisol release, and associated hemodynamic changes. Methods In a 3 × 3 Latin square design, subjects were randomized to recei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62cc67cd9642021ed2e2a575129b1d53
https://doi.org/10.1016/s0009-9236(98)90133-3
https://doi.org/10.1016/s0009-9236(98)90133-3
Publikováno v:
Oceanography. 2018 Supplement, Vol. 31, p91-91. 1p.
Publikováno v:
Pharmaceutical biotechnology. 13
Control of chemical instability in protein pharmaceuticals continues to be a critical issue in developing stable formulations. While the effects of pH, buffer composition, ionic strength and temperature remain the most effective methods for controlli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2c8b221d01a295b770dfaf99ed088fda
https://pubmed.ncbi.nlm.nih.gov/11987755
https://pubmed.ncbi.nlm.nih.gov/11987755
Publikováno v:
Pharmaceutical Biotechnology ISBN: 9781461351313
Although most of the attention on the stability of protein and peptide pharmaceuticals has focused on denaturation and aggregation, chemical degradation cannot be ignored. A large number of possible chemical reactions have been identified as leading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::183e47e66e95455023f1317fe6ae3d40
https://doi.org/10.1007/978-1-4615-0557-0_4
https://doi.org/10.1007/978-1-4615-0557-0_4
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 16(1)
A selective HPLC/RIA procedure for the determination of dynorphin A1-13 (Dyn A1-13) and its major metabolites in human blood was developed. In order to block peptidase activity, blood samples were transferred into an aliquot of a blocking solution (5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d10705672755a3ec802296597e1bf94
https://pubmed.ncbi.nlm.nih.gov/9447557
https://pubmed.ncbi.nlm.nih.gov/9447557
Publikováno v:
Biochemical and Biophysical Research Communications. 149:319-325
The oxidation of 1,1,2,2-tetrachloroethane to dichloroacetic acid was investigated with rat liver microsomes and purified cytochrome P-450. Deuterium substitution had no effect on Km values, but both the inter- and intramolecular isotope effects ( k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3636a0fb10bb5ebca4c5904a850a083b
https://doi.org/10.1016/0006-291x(87)90369-x
https://doi.org/10.1016/0006-291x(87)90369-x
Publikováno v:
Analytical Biochemistry. 145:376-384
A dynamic headspace technique was developed to facilitate the identification and quantitation of low levels of volatile metabolites produced in vitro by subcellular preparations. The method is complementary to commonly used static headspace and solve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c552186f6c048b9d3834960c55b9f72
https://doi.org/10.1016/0003-2697(85)90377-x
https://doi.org/10.1016/0003-2697(85)90377-x
Autor:
Bert Ho, Neal Castagnoli
Publikováno v:
Journal of Medicinal Chemistry. 23:133-139
Incubations of 1-benzylpyrrolidine (4) and specifically deuterium-labeled analogues of 4 with rabbit liver microsomal preparations in the presence of cyanide ion have led to the characterization of 1-benzyl-2-cyanopyrrolidine (13), cis- and trans-1-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7eec09c2f8acea1f3779571e68964e
https://doi.org/10.1021/jm00176a006
https://doi.org/10.1021/jm00176a006
Publikováno v:
Journal of medicinal chemistry. 24(10)
The popular antihistamine methapyrilene [N,N-dimethyl-N'-(2-pyridyl)-N'-(2-thienylmethyl)-1,2-ethanediamine] recently has been shown to be a potent hepatocarcinogen. Metabolic studies with rabbit liver 100000g microsomal preparations have resulted in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa67c126ecba4eb3d1689bf9e596347
https://pubmed.ncbi.nlm.nih.gov/7328575
https://pubmed.ncbi.nlm.nih.gov/7328575