Výsledky vyhledávání - "Bert F, Bernard"

Peptide Receptor Radionuclide Therapy: Preclinical Findings

Autor: Eric P. Krenning, Astrid Capello, Wouter A.P. Breeman, Bert F. Bernard, Marion de Jong

Publikováno v: Radionuclide Peptide Cancer Therapy ISBN: 9780429116674

Somatostatin is a cyclopeptide that has a broad inhibitory effect on the secretion of hormones such as growth hormone, glucagon, and insulin. The molecular basis of the use of radiolabeled octreotide in scintigraphy and radionuclide therapy is recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df118aaa64d662de24b44facc8579146
https://doi.org/10.3109/9781420016727-6

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Bone marrow dosimetry in peptide receptor radionuclide therapy with [Lu-177-DOTA(0),Tyr(3)]octreotate

Autor: P. P. M. Kooij, Eric P. Krenning, Bert F. Bernard, Willem H. Bakker, Mark Konijnenberg, Marion de Jong, Dik J. Kwekkeboom, Flavio Forrer, Jaap J.M. Teunissen, Wouter W. de Herder, Kirsten van Lom

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging
European Journal of Nuclear Medicine and Molecular Imaging, 36(7), 1138-1146. Springer-Verlag

Purpose Adequate dosimetry is mandatory for effective and safe peptide receptor radionuclide therapy (PRRT). Besides the kidneys, the bone marrow is a potentially dose-limiting organ. The radiation dose to the bone marrow is usually calculated accord

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b43cf320aa272cc60d183df0e72f501
https://hdl.handle.net/1765/24162

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Molecular imaging of reduced renal uptake of radiolabelled [DOTA(0),Tyr(3)]octreotate by the combination of lysine and Gelofusine in rats

Autor: Otto C. Boerman, Martin Gotthardt, Edgar J. Rolleman, J. W. Hoppin, M. De Jong, Wouter A.P. Breeman, E. de Blois, Flavio Forrer, Bert F. Bernard, E. P. Krenning

Publikováno v: Nuklearmedizin. Nuclear Medicine, 47, 3, pp. 110-5
Nuclear Medicine-Nuklearmedizin, 47(3), 110-115. Georg Thieme Verlag
Nuklearmedizin. Nuclear Medicine, 47, 110-5

SummaryAim: In peptide receptor radionuclide therapy (PRRT) using radiolabelled somatostatin analogues, kidney uptake of radiolabelled compound is the major dose-limiting factor. We studied the effects of Gelofusine (20 mg) and lysine (100 mg) and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d40f2e04a067544d51c4b276e492902
https://pure.eur.nl/en/publications/3f0aab80-0f6f-4215-8b0f-18fca710867e

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From outside to inside? Dose-dependent renal tubular damage after high-dose peptide receptor radionuclide therapy in rats measured with in vivo Tc-99m-DMSA-SPECT and molecular imaging

Autor: Eric P. Krenning, Marion de Jong, Flavio Forrer, Marleen Melis, Magda Bijster, Bert F. Bernard, Edgar J. Rolleman

Publikováno v: Cancer Biotherapy & Radiopharmaceuticals, 22(1), 40-49. Mary Ann Liebert Inc.

In peptide receptor radionuclide therapy (PRRT), the dose-limiting organ is, most often, the kidney. However, the precise mechanism as well as the exact localization of kidney damage during PRRT have not been fully elucidated. We studied renal damage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::839b193bdc960173f8cbe7a030d15a35
https://doi.org/10.1089/cbr.2006.353

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Long-term toxicity of [Lu-177-DOTA(0),Tyr(3)]octreotate in rats

Autor: Eric P. Krenning, Theo J. Visser, Magda Bijster, Bert F. Bernard, Marcel Vermeij, Edgar J. Rolleman, Jan Lindemans, Marion de Jong, Monique de Visser

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging, 34(2), 219-227. Springer-Verlag

Studies on peptide receptor radionuclide therapy (PRRT) using radiolabelled somatostatin analogues have shown promising results with regard to tumour control. The efficacy of PRRT is limited by uptake and retention in the proximal tubules of the kidn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d082dee83af7fef37cd7ff774224ba5
https://pure.eur.nl/en/publications/735a0644-cdae-4f6c-bfde-2cf156f2d053

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[99mTc]Demotate 2 in the detection of sst2-positive tumours: a preclinical comparison with [111In]DOTA-tate

Autor: Ria van den Berg, Wout A.P. Breeman, Paul Cordopatis, Eric P. Krenning, Jean Claude Reubi, Arthur van Gameren, Marion de Jong, Theodosia Maina, Berthold A. Nock, Bert F. Bernard

Publikováno v: Maina, Theodosia; Nock, Berthold A; Cordopatis, Paul; Bernard, Bert F; Breeman, Wout A P; van Gameren, Arthur; van den Berg, Ria; Reubi, Jean-Claude; Krenning, Eric P; de Jong, Marion (2006). [(99m)Tc]Demotate 2 in the detection of sst(2)-positive tumours: a preclinical comparison with [(111)In]DOTA-tate. European journal of nuclear medicine and molecular imaging, 33(7), pp. 831-40. Berlin: Springer 10.1007/s00259-006-0068-8

PURPOSE: The aim of this study was to evaluate [(99m)Tc]Demotate 2 ([(99m)Tc-N(4) (0-1),Asp(0),Tyr(3)]octreotate) as a candidate for in vivo imaging of sst(2)-positive tumours and to compare it with [(111)In]DOTA-tate ([(111)In-DOTA(0),Tyr(3)]octreot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f34974742fcd8243f9a8a79b5be45f4b
https://doi.org/10.1007/s00259-006-0068-8

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In vivo radionuclide uptake quantification using a multi-pinhole SPECT system to predict renal function in small animals

Autor: M. De Jong, Flavio Forrer, Roelf Valkema, Bert F. Bernard, J. W. Hoppin, E. P. Krenning, N. U. Schramm, Edgar J. Rolleman

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging, 33(10), 1214-1217. Springer-Verlag

In vivo quantification of radiopharmaceuticals has great potential as a tool in developing new drugs. We investigated the accuracy of in vivo quantification with multi-pinhole single-photon emission computed tomography (SPECT) in rats.Fifteen male Le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82927ab232d596453f34a3fddd8e3ef8
https://doi.org/10.1007/s00259-006-0178-3

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In-111-labelled somatostatin analogues in a rat tumour model: somatostatin receptor status and effects of peptide receptor radionuclide therapy

Autor: Eric P. Krenning, Wouter A.P. Breeman, Astrid Capello, Marcel de Jong, Bert F. Bernard, Jean Claude Reubi

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging, 32(11), 1288-1295. Springer-Verlag

Peptide receptor scintigraphy with the radioactive somatostatin analogue 111In-DTPA-octreotide is a sensitive and specific technique to show in vivo the presence of somatostatin receptors on various tumours. Since 111In emits not only gamma rays but

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5dd6f7de7c4fe064cb9fb56a02b68f3
https://pure.eur.nl/en/publications/42a52a1f-f896-44d7-a074-6f01ea359c71

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Radiolabeled RGD-DTPA-Tyr3-Octreotate for Receptor-Targeted Radionuclide Therapy

Autor: Martin van Hagen, Jack L. Erion, Astrid Capello, Eric P. Krenning, Ananth Srinivasan, Wout A.P. Breeman, Marion de Jong, Bert F. Bernard, Arthur van Gameren, Michelle A. Schmidt

Publikováno v: Cancer Biotherapy & Radiopharmaceuticals, 19(2), 173-180. Mary Ann Liebert Inc.

The aim of this study was to develop and investigate a radiopeptide for the treatment of cancers which overexpress cell surface somatostatin receptors. The new radiopharmaceutical is composed of a somatostatin receptor-targeting peptide, a chelator (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af536be697caa420d832b7d131b703c7
https://doi.org/10.1089/108497804323071940

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