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Akademický článek

Toxicological evaluation of the flavour ingredient N-(1-((4-amino-2,2-dioxido-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)-2-methylpropan-2-yl)-2,6-dimethylisonicotinamide (S2218)

Autor: Donald S. Karanewsky, Guy Servant, Hanghui Liu, Bert Chi, Lily Ida, Michael Saganich, Sara Werner, Joseph R. Fotsing, Andrew Patron, Catherine Tachdjian, Amy Arthur

Publikováno v: Toxicology Reports, Vol 4, Iss , Pp 507-520 (2017)

A toxicological evaluation of N-(1-((4-amino-2,2-dioxido-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)-2-methylpropan-2-yl)-2,6-dimethylisonicotinamide (S2218; CAS 1622458-34-7), a flavour with modifying properties, was completed for the purpose of assessin

Externí odkaz: https://doaj.org/article/e104bf811a6b41778b1fd0b467f96e72

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Akademický článek

Toxicological evaluation and metabolism of two N-alkyl benzamide umami flavour compounds: N-(heptan-4-yl)benzo[d][1,3]dioxole-5-carboxamide and (R)-N-(1-methoxy-4-methylpentan-2-yl)-3,4-dimethylbenzamide

Autor: Donald S. Karanewsky, Amy J. Arthur, Hanghui Liu, Bert Chi, Lily Ida

Publikováno v: Toxicology Reports, Vol 3, Iss , Pp 841-860 (2016)

Toxicological evaluations of two N-alkyl benzamide umami flavour compounds, N-(heptan-4-yl)benzo[d][1,3]dioxole-5-carboxamide (S807, CAS 745047-51-2) and (R)-N-(1-methoxy-4-methylpentan-2-yl)-3,4-dimethylbenzamide (S9229, CAS 851669-60-8), were compl

Externí odkaz: https://doaj.org/article/2a7c4d79dfb84c8291102490eb09963d

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Akademický článek

Toxicological evaluation of a novel umami flavour compound: 2-(((3-(2,3-Dimethoxyphenyl)-1H-1,2,4-triazol-5-yl)thio)methyl)pyridine

Autor: Donald S. Karanewsky, Amy J. Arthur, Hanghui Liu, Bert Chi, Lily Ida, Stacy Markison

Publikováno v: Toxicology Reports, Vol 3, Iss , Pp 501-512 (2016)

A toxicological evaluation of a umami flavour compound, 2-(((3-(2,3-dimethoxyphenyl)-1H-1,2,4-triazol-5-yl)thio)methyl)pyridine (S3643; CAS 902136-79-2), was completed for the purpose of assessing its safety for use in food and beverage applications.

Externí odkaz: https://doaj.org/article/dc58427212f94ef9866f9ec8d04ef7b6

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Akademický článek

Toxicological evaluation of two novel bitter modifying flavour compounds: 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(3-hydroxybenzyl)imidazolidine-2,4-dione and 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(3-hydroxybenzyl)-5,5-dimethylimidazolidine-2,4-dione

Autor: Donald S. Karanewsky, Amy J. Arthur, Hanghui Liu, Bert Chi, Lily Ida, Stacy Markison

Publikováno v: Toxicology Reports, Vol 3, Iss , Pp 310-327 (2016)

A toxicological evaluation of two novel bitter modifying flavour compounds, 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(3-hydroxybenzyl)imidazolidine-2,4-dione (S6821, CAS 1119831-25-2) and 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H

Externí odkaz: https://doaj.org/article/909c54b40a4347f3a82d42ea4319a457

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Akademický článek

Toxicological evaluation of a novel cooling compound: 2-(4-methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(2-thienylmethyl)acetamide

Autor: Donald S. Karanewsky, Amy J. Arthur, Hanghui Liu, Bert Chi, Stacy Markison

Publikováno v: Toxicology Reports, Vol 2, Iss C, Pp 1291-1309 (2015)

A toxicological evaluation of a novel cooling agent, 2-(4-methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(2-thienylmethyl) acetamide (S2227; CAS 1374760-95-8), was completed for the purpose of assessing its safety for use in food and beverage applications. S22

Externí odkaz: https://doaj.org/article/29af3a50ab834f12a39262c7460ad779

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Akademický článek

Toxicological evaluation of the flavour ingredient 4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid

Autor: Amy J. Arthur, Donald S. Karanewsky, Hanghui Liu, Bert Chi, Stacy Markison

Publikováno v: Toxicology Reports, Vol 2, Iss C, Pp 1255-1264 (2015)

A toxicological evaluation of 4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid(S9632; CAS 1359963-68-0), a flavour with modifying properties,was completed for the purpose of assessing its safety for use in

Externí odkaz: https://doaj.org/article/de7f947cf602457a920213136f2b4a94

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Toxicological evaluation of the flavour ingredient N -(1-((4-amino-2,2-dioxido-1 H -benzo[ c ][1,2,6]thiadiazin-5-yl)oxy)-2-methylpropan-2-yl)-2,6-dimethylisonicotinamide (S2218)

Autor: Bert Chi, Andrew Patron, Michael Saganich, Sara Werner, Catherine Tachdjian, Guy Servant, Amy J. Arthur, Joseph R. Fotsing, Lily Ida, Hanghui Liu, Donald S. Karanewsky

Publikováno v: Toxicology Reports, Vol 4, Iss, Pp 507-520 (2017)
Toxicology Reports

Graphical abstract The results of the ADME, genotoxicity, rodent toxicology and developmental toxicology studies conducted on a new flavour compound S2218 are reported. S2218 is a positive allosteric modifier (PAM) of the human sweet taste receptor a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcdef84c8da13f7445a16395430628f3
https://doi.org/10.1016/j.toxrep.2017.09.004

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Transient Ion-Pair Separations for Electrospray Mass Spectrometry

Autor: Akinde F. Kadjo, Bert Chi, Lily Lam, Purnendu K. Dasgupta, Hanghui Liu

Publikováno v: Analytical Chemistry. 88:2059-2064

We report a novel ion-pair chromatography (IPC) approach for liquid chromatography electrospray ionization mass spectrometry (LC-ESI-MS), where the eluent does not contain any ion-pairing reagent (IPR). The IPR is injected on the column, much like th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5624fd243b8e0e74c842ea927211cb6
https://doi.org/10.1021/acs.analchem.5b03202

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