Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Bert A. 't Hart"'
Autor:
Antonio Luchicchi, Gema Muñoz‐Gonzalez, Saar T. Halperin, Eva Strijbis, Laura H. M. vanDijk, Chrisa Foutiadou, Florence Uriac, Piet M. Bouman, Maxime A. N. Schouten, Jason Plemel, Bert A. 't Hart, Jeroen J. G. Geurts, Geert J. Schenk
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 4, Pp 973-988 (2024)
Abstract Objective Multiple sclerosis (MS) is a chronic central nervous system disease whose white matter lesion origin remains debated. Recently, we reported subtle changes in the MS normal appearing white matter (NAWM), presenting with an increase
Externí odkaz:
https://doaj.org/article/d8d2dffb6da843f480f1c9a84eb1ea1f
Autor:
Peter K. Stys, Shigeki Tsutsui, Arie R. Gafson, Bert A. ‘t Hart, Shibeshih Belachew, Jeroen J. G. Geurts
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Multiple sclerosis (MS) is a frequently disabling neurological disorder characterized by symptoms, clinical signs and imaging abnormalities that typically fluctuate over time, affecting any level of the CNS. Prominent lymphocytic inflammation, many g
Externí odkaz:
https://doaj.org/article/c57060beacc04081b04c01066f7e86ab
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 8, Pp 1709-1719 (2021)
Abstract The neuroinflammatory disease multiple sclerosis is driven by autoimmune pathology in the central nervous system. However, the trigger of the autoimmune pathogenic process is unknown. MS models in immunologically naïve, specific‐pathogen
Externí odkaz:
https://doaj.org/article/60bc53c765fe4325b8ff4803e9746646
Autor:
Maria Elisa Perez-Muñoz, Scott Sugden, Hermie J.M. Harmsen, Bert A. ‘t Hart, Jon D. Laman, Jens Walter
Publikováno v:
iScience, Vol 24, Iss 7, Pp 102709- (2021)
Summary: Studies in experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis, have shown potential links between diet components, microbiome composition, and modulation of immune responses. In this review, we reanalyze
Externí odkaz:
https://doaj.org/article/b1bd2e637a94468ebbc7b275129c07aa
Publikováno v:
EBioMedicine, Vol 68, Iss , Pp 103392- (2021)
Multiple sclerosis (MS) is after trauma the most important neurological disease in young adults, affecting 1 per 1000 individuals. With currently available medications, most of these targeting the immune system, satisfactory results have been obtaine
Externí odkaz:
https://doaj.org/article/5e413e86f6bf46689e78b9d22d475dec
Autor:
Claire-Maëlle Fovet, Lev Stimmer, Vanessa Contreras, Philippe Horellou, Audrey Hubert, Nabila Seddiki, Catherine Chapon, Sabine Tricot, Carole Leroy, Julien Flament, Julie Massonneau, Nicolas Tchitchek, Bert A. 't Hart, Sandra Zurawski, Peter Klucar, Philippe Hantraye, Kumaran Deiva, Gerard Zurawski, SangKon Oh, Roger Le Grand, Ché Serguera
Publikováno v:
EBioMedicine, Vol 47, Iss , Pp 492-505 (2019)
Background: Autoimmune demyelinating diseases (ADD) are a major cause of neurological disability due to autoreactive cellular and humoral immune responses against brain antigens. A cure for chronic ADD could be obtained by appropriate immunomodulatio
Externí odkaz:
https://doaj.org/article/8dcb23ba52be4f9b83ca67c40e294427
Publikováno v:
Biomedicines, Vol 10, Iss 3, p 606 (2022)
Multiple sclerosis (MS) is a neurodegenerative disease of the central nervous system (CNS), traditionally considered a chronic autoimmune attack against the insulating myelin sheaths around axons. However, the exact etiology has not been identified a
Externí odkaz:
https://doaj.org/article/0f15e98eab704fa4b919db9c03a5f4f1
Autor:
Marije K. Verheul, Michel P. M. Vierboom, Bert A. ’t Hart, Rene E. M. Toes, Leendert A. Trouw
Publikováno v:
Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-7 (2017)
Abstract Background Rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA) and anti-carbamylated protein (anti-CarP) antibodies are rheumatoid arthritis (RA)-associated autoantibodies. Besides their presence in human serum, anti-CarP an
Externí odkaz:
https://doaj.org/article/9af160a230664570a3b6469659a26340
Autor:
Mario Losen, Aran F. Labrijn, Vivianne H. van Kranen-Mastenbroek, Maarten L. Janmaat, Krista G. Haanstra, Frank J. Beurskens, Tom Vink, Margreet Jonker, Bert A. ‘t Hart, Marina Mané-Damas, Peter C. Molenaar, Pilar Martinez-Martinez, Eline van der Esch, Janine Schuurman, Marc H. de Baets, Paul W. H. I. Parren
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Autoantibodies against ion channels are the cause of numerous neurologic autoimmune disorders. Frequently, such pathogenic autoantibodies have a restricted epitope-specificity. In such cases, competing antibody formats devoid of pathogenic e
Externí odkaz:
https://doaj.org/article/24f5b6bf021946909f7c67a223ec548b
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Multiple sclerosis (MS) is an autoimmune neurological disease characterized by chronic inflammation of the central nervous system (CNS), leading to demyelination, axonal damage, and symptoms such as fatigue and disability. Although the cause of MS is
Externí odkaz:
https://doaj.org/article/a22fcc42df844141bed3dfdc8d78e848