Production of a high purity, C-tagged hepatitis B surface antigen fusion protein VLP vaccine for malaria expressed in Pichia pastoris under cGMP conditions

Autor: Mukhopadhyay, E, Brod, F, Angell-Manning, P, Green, N, Tarrant, RD, Detmers, FJ, Bolam, EJ, Baleanu, IN, Hobson, M, Whale, G, Morris, SJ, Ashfield, R, Gilbert, SC, Jin, J, Draper, SJ, Moyle, SP, Berrie, EL, Hill, AVS

Virus-like particles (VLPs) induce strong humoral and cellular responses and have formed the basis of some currently licensed vaccines. Here, we present the method used for the production of R21, a VLP-based anti-sporozoite malaria vaccine, under cur

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Production of a high purity, C-tagged hepatitis B surface antigen fusion protein VLP vaccine for malaria expressed in Pichia pastoris under cGMP conditions.

Autor: Mukhopadhyay E; Clinical BioManufacturing Facility, The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Brod F; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Angell-Manning P; Clinical BioManufacturing Facility, The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Green N; Clinical BioManufacturing Facility, The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Tarrant RD; Clinical BioManufacturing Facility, The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Detmers FJ; Thermo Fisher Scientific, Leiden, The Netherlands., Bolam EJ; Clinical BioManufacturing Facility, The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Baleanu IN; Clinical BioManufacturing Facility, The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Hobson M; Clinical BioManufacturing Facility, The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Whale G; Clinical BioManufacturing Facility, The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Morris SJ; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Ashfield R; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Gilbert SC; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Jin J; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Draper SJ; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Moyle SP; Clinical BioManufacturing Facility, The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Berrie EL; Clinical BioManufacturing Facility, The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Hill AVS; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Publikováno v: Biotechnology and bioengineering [Biotechnol Bioeng] 2022 Oct; Vol. 119 (10), pp. 2784-2793. Date of Electronic Publication: 2022 Jul 22.

Hybrid human immunodeficiency virus Gag particles as an antigen carrier system: induction of cytotoxic T-cell and humoral responses by a Gag:V3 fusion.

Autor: Griffiths JC; British Bio-technology Ltd., Cowley, Oxford, United Kingdom., Harris SJ, Layton GT, Berrie EL, French TJ, Burns NR, Adams SE, Kingsman AJ

Publikováno v: Journal of virology [J Virol] 1993 Jun; Vol. 67 (6), pp. 3191-8.

A cytotoxic T-lymphocyte line propagated from a rabbit infected with sheep associated malignant catarrhal fever.

Autor: Reid HW, Buxton D, Pow I, Finlayson J, Berrie EL

Publikováno v: Research in veterinary science [Res Vet Sci] 1983 Jan; Vol. 34 (1), pp. 109-13.