Thyroid hormone remodels cortex to coordinate body-wide metabolism and exploration.

Autor: Hochbaum DR; Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; Society of Fellows, Harvard University, Cambridge, MA 02138, USA., Hulshof L; Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Urke A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA., Wang W; Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Dubinsky AC; Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Farnsworth HC; Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Hakim R; Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Lin S; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Kleinberg G; Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Robertson K; Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Park C; Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Solberg A; Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Yang Y; Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Baynard C; Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Nadaf NM; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Beron CC; Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Girasole AE; Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Chantranupong L; Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Cortopassi MD; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA., Prouty S; Department of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA., Geistlinger L; Center for Computational Biomedicine, Harvard Medical School, Boston, MA 02215, USA., Banks AS; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA., Scanlan TS; Department of Chemical Physiology & Biochemistry, Oregon Health & Science University, Portland, OR 97239, USA., Datta SR; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Greenberg ME; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA., Boulting GL; Department of Neurobiology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA., Macosko EZ; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA., Sabatini BL; Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: bernardo_sabatini@hms.harvard.edu.

Publikováno v: Cell [Cell] 2024 Oct 03; Vol. 187 (20), pp. 5679-5697.e23. Date of Electronic Publication: 2024 Aug 22.

Thyroid hormone rewires cortical circuits to coordinate body-wide metabolism and exploratory drive.

Autor: Hochbaum DR, Dubinsky AC, Farnsworth HC, Hulshof L, Kleinberg G, Urke A, Wang W, Hakim R, Robertson K, Park C, Solberg A, Yang Y, Baynard C, Nadaf NM, Beron CC, Girasole AE, Chantranupong L, Cortopassi M, Prouty S, Geistlinger L, Banks A, Scanlan T, Greenberg ME, Boulting GL, Macosko EZ, Sabatini BL

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Aug 10. Date of Electronic Publication: 2023 Aug 10.

The Striatum Organizes 3D Behavior via Moment-to-Moment Action Selection.

Autor: Markowitz JE; Department of Neurobiology, Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA., Gillis WF; Department of Neurobiology, Harvard Medical School, Boston, MA, USA., Beron CC; Department of Neurobiology, Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA., Neufeld SQ; Department of Neurobiology, Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA., Robertson K; Department of Neurobiology, Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA., Bhagat ND; Department of Neurobiology, Harvard Medical School, Boston, MA, USA., Peterson RE; Department of Neurobiology, Harvard Medical School, Boston, MA, USA., Peterson E; Department of Neurobiology, Harvard Medical School, Boston, MA, USA., Hyun M; Department of Neurobiology, Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA., Linderman SW; Grossman Center for the Statistics of Mind, Columbia University, New York, NY, USA; Departments of Statistics and Computer Science, Columbia University, New York, NY, USA., Sabatini BL; Department of Neurobiology, Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA., Datta SR; Department of Neurobiology, Harvard Medical School, Boston, MA, USA. Electronic address: srdatta@hms.harvard.edu.

Publikováno v: Cell [Cell] 2018 Jun 28; Vol. 174 (1), pp. 44-58.e17. Date of Electronic Publication: 2018 May 17.