Výsledky vyhledávání - "Bernice Kuca"

Akademický článek

A phase I/II study on intracerebroventricular tralesinidase alfa in patients with Sanfilippo syndrome type B

Autor: Nicole Muschol, Anja Koehn, Katharina von Cossel, Ilyas Okur, Fatih Ezgu, Paul Harmatz, Maria J. de Castro Lopez, Maria Luz Couce, Shuan-Pei Lin, Spyros Batzios, Maureen Cleary, Martha Solano, Igor Nestrasil, Brian Kaufman, Adam J. Shaywitz, Stephen M. Maricich, Bernice Kuca, Joseph Kovalchin, Eric Zanelli

Publikováno v: The Journal of Clinical Investigation, Vol 133, Iss 2 (2023)

Background Sanfilippo type B is a mucopolysaccharidosis (MPS) with a major neuronopathic component characterized by heparan sulfate (HS) accumulation due to mutations in the NAGLU gene encoding alfa-N-acetyl-glucosaminidase. Enzyme replacement therap

Externí odkaz: https://doaj.org/article/3ded75f715844309990af3452c9afcb6

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A phase 1/2 study on intracerebroventricular tralesinidase alfa in patients with Sanfilippo syndrome type B

Autor: Nicole, Muschol, Anja, Koehn, Katharina, von Cossel, Ilyas, Okur, Fatih, Ezgu, Paul, Harmatz, Maria Jose, de Castro Lopez, Maria Luz, Couce, Shuan-Pei, Lin, Spyros, Batzios, Maureen, Cleary, Martha, Solano, Igor, Nestrasil, Brian D, Kaufman, Adam J, Shaywitz, Stephen M, Maricich, Bernice, Kuca, Joseph, Kovalchin, Eric H, Zanelli

Publikováno v: The Journal of clinical investigation.

Sanfilippo type B is a mucopolysaccharidosis (MPS) with a major neuronopathic component characterized by heparan sulfate (HS) accumulation due to mutations in the NAGLU gene encoding for alfa-N-acetyl-glucosaminidase. Enzyme replacement therapy for n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ba973441d24cec11806948a9a8f39f70
https://pubmed.ncbi.nlm.nih.gov/36413418

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Longitudinal Natural History of Pediatric Subjects Affected with Mucopolysaccharidosis IIIB

Publikováno v: The Journal of pediatrics. 249

To characterize the longitudinal natural history of disease progression in pediatric subjects affected with mucopolysaccharidosis (MPS) IIIB.Sixty-five children with a confirmed diagnosis of MPS IIIB were enrolled into 1 of 2 natural history studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ad41235c50033b04013663829af070
https://pubmed.ncbi.nlm.nih.gov/35709957

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Lasmiditan is an effective acute treatment for migraine

Autor: Bernice, Kuca, Stephen D, Silberstein, Linda, Wietecha, Paul H, Berg, Gregory, Dozier, Richard B, Lipton, Thomas, Wolf

Publikováno v: Neurology. 91:e2222-e2232

ObjectiveTo assess the efficacy and safety of lasmiditan in the acute treatment of migraine.MethodsAdult patients with migraine were randomized (1:1:1) to a double-blind dose of oral lasmiditan 200 mg, lasmiditan 100 mg, or placebo and were asked to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad021d8a7e986d4e8d2d6cfacb90a21
https://doi.org/10.1212/wnl.0000000000006641

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Phase 3 randomized, placebo-controlled, double-blind study of lasmiditan for acute treatment of migraine

Autor: Sheena K. Aurora, Linda Wietecha, Ellen B. Dennehy, Peter J. Goadsby, Michael Case, Bernice Kuca, Charly Gaul

Publikováno v: Brain

Lasmiditan is a selective 5-HT1F receptor agonist without vasoconstrictive activity. In this phase 3 double-blind placebo-controlled study, Goadsby et al. show that lasmiditan is efficacious and relatively well tolerated in the acute treatment of mig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9de84849f37671ebdb3970da7fa35c
https://pubmed.ncbi.nlm.nih.gov/31132795

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Efficacy and Tolerability of Lasmiditan, an Oral 5-HT1F Receptor Agonist, for the Acute Treatment of Migraine: A Phase 3 Randomized, Placebo-Controlled, Double-Blind Study

Autor: Charly Gaul, Sheena K. Aurora, Linda Wietecha, Ellen B. Dennehy, Michael Case, Peter J. Goadsby, Bernice Kuca

Publikováno v: SSRN Electronic Journal.

Background: Lasmiditan, a serotonin 5-HT1F receptor agonist, was effective for acute treatment of patients with migraine in phase 2 studies. We aimed to replicate these findings in a population that includes patients with migraine and cardiovascular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::095d6a1bc0593f2f7c0e309241d44a35
https://doi.org/10.2139/ssrn.3228912

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A phase I trial of recombinant human interleukin-11 (neumega rhIL-11 growth factor) in women with breast cancer receiving chemotherapy

Autor: George W. Sledge, Kathleen J. Beach, John Loewy, Linda A. Battiato, Worta McCaskill-Stevens, Elyse Breeden, Ron Hoffman, Bernice Kuca, James A. Kaye, David Loesch, Michael S. Gordon

Publikováno v: Blood. 87:3615-3624

We performed a phase I trial of recombinant human interleukin-11 (rhIL- 11) in women with breast cancer. Cohorts of three to five women were accrued to five dosage levels of rhIL-11 (10, 25, 50, 75, and 100 micrograms/kg/d). rhIL-11 alone was adminis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78ea61d5a08d9a6af486132377c343ea
https://doi.org/10.1182/blood.v87.9.3615.bloodjournal8793615

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