Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Bernice, H Wong"'
Autor:
Cheen Fei Chin, Dwight L.A. Galam, Liang Gao, Bryan C. Tan, Bernice H. Wong, Geok-Lin Chua, Randy Y.J. Loke, Yen Ching Lim, Markus R. Wenk, Miao-Shan Lim, Wei-Qiang Leow, George B.B. Goh, Federico Torta, David L. Silver
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 17 (2023)
The liver has a high demand for phosphatidylcholine (PC), particularly in overnutrition, where reduced phospholipid levels have been implicated in the development of nonalcoholic fatty liver disease (NAFLD). Whether other pathways exist in addition t
Externí odkaz:
https://doaj.org/article/65986795ef3e486290872e1e79aa32e1
Autor:
Randy Y.J. Loke, Cheen Fei Chin, Gao Liang, Bernice H. Wong, Dwight L.A. Galam, Bryan C. Tan, Geok-Lin Chua, Shintaro Minegishi, Norihiko Morisawa, Iulia Sidorov, Bram Heijs, Jens Titze, Markus R. Wenk, Federico Torta, David L. Silver
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 8, Pp 100416- (2023)
Acute kidney injury (AKI) is a global public health concern with high mortality and morbidity. In ischemic–reperfusion injury (IRI), a main cause of AKI, the brush border membrane of S3 proximal tubules (PT) is lost to the tubular lumen. How injure
Externí odkaz:
https://doaj.org/article/672d13e383c743709655a740077d87eb
Autor:
Vetrivel Sengottuvel, Monalisa Hota, Jeongah Oh, Dwight L. Galam, Bernice H. Wong, Markus R. Wenk, Sujoy Ghosh, Federico Torta, David L. Silver
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)
Patients with autosomal recessive microcephaly 15 caused by deficiency in the sodium-dependent lysophosphatidylcholine (LPC) transporter major facilitator superfamily domain–containing 2a (Mfsd2a) present with both microcephaly and hypomyelination,
Externí odkaz:
https://doaj.org/article/cd1d39b36ed14cd1b8bcc803ac7d39ca
Autor:
Geok-Lin Chua, Bryan C. Tan, Randy Y. J. Loke, Menglan He, Cheen-Fei Chin, Bernice H. Wong, Alvin C. Y. Kuk, Mei Ding, Markus R. Wenk, Lan Guan, Federico Torta, David L. Silver
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Major Facilitator Superfamily Domain containing 2a (Mfsd2a) is a sodium-dependent lysophosphatidylcholine (LPC) transporter expressed at the blood–brain barrier that constitutes the main pathway by which the brain obtains omega-3 fatty acids, such
Autor:
Jia Pei Chan, Bernice H Wong, Cheen Fei Chin, Dwight L A Galam, Juat Chin Foo, Loo Chin Wong, Sujoy Ghosh, Markus R Wenk, Amaury Cazenave-Gassiot, David L Silver
Publikováno v:
PLoS Biology, Vol 16, Iss 8, p e2006443 (2018)
Brain development requires a massive increase in brain lipogenesis and accretion of the essential omega-3 fatty acid docosahexaenoic acid (DHA). Brain acquisition of DHA is primarily mediated by the transporter Major Facilitator Superfamily Domain co
Externí odkaz:
https://doaj.org/article/544aa20fbc204aaf8689028e21a55a66
Autor:
Jun Cheng Er, Nam-Young Kang, David L. Silver, Bernice H. Wong, Veluchamy A Barathi, Young-Tae Chang, Sungjin Park, Xiao Liu, Queenie Tan Shu Woon
Publikováno v:
ChemBioChem. 22:1915-1919
The retina is part of the central nerve system (CNS) and has various interneurons and sensory neurons such as photoreceptor cells. Retinitis pigmentosa (RP) is an inherited condition that is characterized by photoreceptor degeneration. Herein, we dev
Autor:
Greg M. Delgoffe, Ashley V. Menk, Simon C. Watkins, Juat Chin Foo, Amaury Cazenave-Gassiot, Bernice H. Wong, David L. Silver, Heather M. Buechel, Lisa Y. Beppu, Ann R Piccirillo, Callen T. Wallace, William F. Hawse, Markus R. Wenk, Louise M. D’Cruz, Eric J. Hyzny
Publikováno v:
The Journal of Immunology. 203:117-126
Access to nutrients is critical for an effective T cell immune response to infection. Although transporters for sugars and amino acids have previously been described in the context of the CD8+ T cell immune response, the active transport of exogenous
Autor:
Geok Lin Chua, Joseph G. Pepe, James E. Keener, Cheen Fei Chin, David L. Silver, Michael T. Marty, Rosemary J. Cater, Oliver B. Clarke, Satchal K. Erramilli, Giacomo Parisi, Brendon C. Choy, Brian Kloss, Filippo Mancia, George Khelashvili, Piotr Tokarz, Anthony A. Kossiakoff, Debra Q Y Quek, Bernice H. Wong
Publikováno v:
Nature
Docosahexaenoic acid is an omega-3 fatty acid that is essential for neurological development and function, and it is supplied to the brain and eyes predominantly from dietary sources1–6. This nutrient is transported across the blood–brain and blo
Autor:
Bernice H. Wong, Ding Mei, Geok Lin Chua, Dwight L. Galam, Markus R. Wenk, Federico Torta, David L. Silver
Publikováno v:
Journal of Biological Chemistry. 298:101709
Pulmonary surfactant is a lipoprotein complex essential for lung function, and insufficiency or altered surfactant composition is associated with major lung diseases, such as acute respiratory distress syndromes, idiopathic pulmonary fibrosis, and ch
Autor:
Bernice H, Wong, David L, Silver
Publikováno v:
Advances in experimental medicine and biology. 1276
Lipids and essential fatty acids are required for normal brain development and continued photoreceptor membrane biogenesis for the maintenance of vision. The blood-brain barrier and blood-eye barriers prohibit the free diffusion of solutes into the b