Zobrazeno 1 - 10
of 281
pro vyhledávání: '"Bernhart, Stephan H."'
Autor:
Schmidt, Maria, Arshad, Mamoona, Bernhart, Stephan H., Hakobyan, Siras, Arakelyan, Arsen, Loeffler-Wirth, Henry, Binder, Hans
Surveillance of the evolving SARS-CoV-2 genome combined with epidemiological monitoring and emerging vaccination became paramount tasks to control the pandemic which is rapidly changing in time and space. Genomic surveillance must combine generation
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A85411
https://ul.qucosa.de/api/qucosa%3A85411/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A85411/attachment/ATT-0/
Autor:
Bernhart, Stephan H., Kretzmer, Helene, Holdt, Lesca M., Jühling, Frank, Ammerpohl, Ole, Bergmann, Anke K., Northoff, Bernd H., Doose, Gero, Siebert, Reiner, Stadler, Peter F., Hoffmann, Steve
Publikováno v:
Scientific reports 6:37393 Doi: 10.1038/srep37393
Bivalent (poised or paused) chromatin comprises activating and repressing histone modifications at the same location. This combination of epigenetic marks at promoter or enhancer regions keeps genes expressed at low levels but poised for rapid activa
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A15181
https://ul.qucosa.de/api/qucosa%3A15181/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A15181/attachment/ATT-0/
Translational Control by RNA-RNA Interaction: Improved Computation of RNA-RNA Binding Thermodynamics
Autor:
Mückstein, Ulrike, Tafer, Hakim, Bernhart, Stephan H., Hernandez-Rosales, Maribel, Vogel, Jörg, Stadler, Peter F., Hofacker, Ivo L.
The thermodynamics of RNA-RNA interaction consists of two components: the energy necessary to make a potential binding region accessible, i.e., unpaired, and the energy gained from the base pairing of the two interaction partners. We show here that b
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A32007
https://ul.qucosa.de/api/qucosa%3A32007/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A32007/attachment/ATT-0/
Autor:
Bompfünewerer, Athanasius F., Backofen, Rolf, Bernhart, Stephan H., Hertel, Jana, Hofacker, Ivo L., Stadler, Peter F., Will, Sebastian
Dynamic Programming Algorithms solve many standard problems of RNA bioinformatics in polynomial time. In this contribution we discuss a series of variations on these standard methods that implement refined biophysical models, such as a restriction of
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A32162
https://ul.qucosa.de/api/qucosa%3A32162/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A32162/attachment/ATT-0/
Autor:
Backofen, Rolf, Bernhart, Stephan H., Flamm, Christoph, Fried, Claudia, Fritzsch, Guido, Hackermüller, Jörg, Hertel, Jana, Hofacker, Ivo L., Missal, Kristin, Mosig, Axel, Prohaska, Sonja J., Rose, Dominic, Stadler, Peter F., Tanzer, Andrea, Washietl, Stefan, Will, Sebastian
Starting with the discovery of microRNAs and the advent of genome‐wide transcriptomics, non‐protein‐coding transcripts have moved from a fringe topic to a central field research in molecular biology. In this contribution we review the state of
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A32161
https://ul.qucosa.de/api/qucosa%3A32161/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A32161/attachment/ATT-0/
Autor:
Bernhart, Stephan H., Tafer, Hakim, Mückstein, Ulrike, Flamm, Christoph, Stadler, Peter F., Hofacker, Ivo L.
Background: RNA has been recognized as a key player in cellular regulation in recent years. In many cases, non-coding RNAs exert their function by binding to other nucleic acids, as in the case of microRNAs and snoRNAs. The specificity of these inter
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A32119
https://ul.qucosa.de/api/qucosa%3A32119/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A32119/attachment/ATT-0/
The genome-wide search for non-coding RNAs requires efficient methods to compute and compare local secondary structures. Since the exact boundaries of such putative transcripts are typically unknown, arbitrary sequence windows have to be used in prac
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A32108
https://ul.qucosa.de/api/qucosa%3A32108/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A32108/attachment/ATT-0/
Autor:
Mückstein, Ulrike, Tafer, Hakim, Hackermüller, Jörg, Bernhart, Stephan H., Stadler, Peter F., Hofacker, Ivo L.
Background: Reliable prediction of RNA–RNA binding energies is crucial, e.g. for the understanding on RNAi, microRNA–mRNA binding and antisense interactions. The thermodynamics of such RNA–RNA interactions can be understood as the sum of two en
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A32006
https://ul.qucosa.de/api/qucosa%3A32006/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A32006/attachment/ATT-0/
Autor:
Müller, Luise, Hoffmann, Anne, Bernhart, Stephan H., Ghosh, Adhideb, Zhong, Jiawei, Hagemann, Tobias, Sun, Wenfei, Dong, Hua, Noé, Falko, Wolfrum, Christian, Dietrich, Arne, Stumvoll, Michael, Massier, Lucas, Blüher, Matthias, Kovacs, Peter, Chakaroun, Rima, Keller, Maria
Publikováno v:
In eBioMedicine August 2024 106
Motivation: Many classes of functional RNA molecules are characterized by highly conserved secondary structures but little detectable sequence similarity. Reliable multiple alignments can therefore be constructed only when the shared structural featu
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A32111
https://ul.qucosa.de/api/qucosa%3A32111/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A32111/attachment/ATT-0/