Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Bernhards R. Ogutu"'
Autor:
Reagan M. Mogire, Silviane A. Miruka, Dennis W. Juma, Case W. McNamara, Ben Andagalu, Jeremy N. Burrows, Elodie Chenu, James Duffy, Bernhards R. Ogutu, Hoseah M. Akala
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-13 (2024)
Abstract Drug discovery is an intricate and costly process. Repurposing existing drugs and active compounds offers a viable pathway to develop new therapies for various diseases. By leveraging publicly available biomedical information, it is possible
Externí odkaz:
https://doaj.org/article/9abd7be432b44ac9ad401606323a2e80
Autor:
Gladys C. Chemwor, Ben M. Andagalu, Irene A. Onyango, Benjamin H. Opot, Raphael O. Okoth, Redemptah A. Yedah, Jackline A. Juma, Edwin W. Mwakio, Dancan M. Wakoli, Joseph G. Amwoma, Agnes C. Cheruiyot, Dennis W. Juma, Bernhards R. Ogutu, Timothy E. Egbo, Eric C. Garges, Amanda L. Roth, Edwin Kamau, Oliver J. Watson, Hoseah M. Akala
Publikováno v:
International Journal of Infectious Diseases, Vol 132, Iss , Pp 17-25 (2023)
Objectives: This study examined the treatment response of mixed vs single-species Plasmodium falciparum infections to artemisinin-based combination therapies (ACTs). Methods: A total of 1211 blood samples collected on days 0, 7, 14, 21, 28, 35, and 4
Externí odkaz:
https://doaj.org/article/d19083ff7cf44a0d9b137282179c1b84
Publikováno v:
Malaria Journal, Vol 21, Iss 1, Pp 1-11 (2022)
Abstract Background The World Health Organization recommends quinine plus clindamycin as first-line treatment of malaria in the first trimester of pregnancy and as a second-line treatment for uncomplicated falciparum malaria when artemisinin-based dr
Externí odkaz:
https://doaj.org/article/ce16694c116e4f17bb523df184134a70
Autor:
Christine N. L. Wanjala, Elke Bergmann-Leitner, Hoseah M. Akala, Geoffrey Odhiambo, Bernhards R. Ogutu, Ben Andagalu, Edwin Kamau, Daniel Ochiel
Publikováno v:
Malaria Journal, Vol 19, Iss 1, Pp 1-8 (2020)
Abstract Background Naturally acquired immunity (NAI), which is characterized by protection against overt clinical disease and high parasitaemia, is acquired with age and transmission intensity. The role of NAI on the efficacy of anti-malarial drugs,
Externí odkaz:
https://doaj.org/article/9a2116b22ab44a8184f0870694ff6b43
Autor:
Charles O. Obonyo, Bernhards R. Ogutu
Publikováno v:
Malaria Journal, Vol 21, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/5e957743d5c64303a9577bc551129ec9
Autor:
Yash Gupta, Neha Sharma, Snigdha Singh, Jesus G. Romero, Vinoth Rajendran, Reagan M. Mogire, Mohammad Kashif, Jordan Beach, Walter Jeske, Poonam, Bernhards R. Ogutu, Stefan M. Kanzok, Hoseah M. Akala, Jennifer Legac, Philip J. Rosenthal, David J. Rademacher, Ravi Durvasula, Agam P. Singh, Brijesh Rathi, Prakasha Kempaiah
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1371 (2022)
Malaria elimination urgently needs novel antimalarial therapies that transcend resistance, toxicity, and high costs. Our multicentric international collaborative team focuses on developing multistage antimalarials that exhibit novel mechanisms of act
Externí odkaz:
https://doaj.org/article/51f533a3d8a647a8b2b71052ec3441fa
Autor:
Douglas O. Ochora, Esezah K. Kakudidi, Jane Namukobe, Perpetua Ipulet, Dancan M. Wakoli, Winnie Okore, Edwin W. Mwakio, Redempthah A. Yeda, Agnes C. Cheruiyot, Dennis W. Juma, Ben Andagalu, Amanda L. Roth, Bernhards R. Ogutu, Abiy Yenesew, Hoseah M. Akala
Publikováno v:
Plants, Vol 11, Iss 1, p 47 (2021)
Malaria is the most lethal parasitic disease in the world. The frequent emergence of resistance by malaria parasites to any drug is the hallmark of sustained malaria burden. Since the deployment of artemisinin-based combination therapies (ACTs) it is
Externí odkaz:
https://doaj.org/article/27b43c3627354952ad059357c663a37f
Autor:
Christian N. Nguetse, Ayola Akim Adegnika, Tsiri Agbenyega, Bernhards R. Ogutu, Sanjeev Krishna, Peter G. Kremsner, Thirumalaisamy P. Velavan
Publikováno v:
Malaria Journal, Vol 16, Iss 1, Pp 1-9 (2017)
Abstract Background The Plasmodium falciparum multidrug resistance 1 (PfMDR1), P. falciparum Ca2+-ATPase (PfATP6) and Kelch-13 propeller domain (PfK13) loci are molecular markers of parasite susceptibility to anti-malarial drugs. Their frequency dist
Externí odkaz:
https://doaj.org/article/b9eb2a0e5e4c496985dec5a6d4f4045f
Autor:
Angela O. Achieng, Peninah Muiruri, Luicer A. Ingasia, Benjamin H. Opot, Dennis W. Juma, Redemptah Yeda, Bidii S. Ngalah, Bernhards R. Ogutu, Ben Andagalu, Hoseah M. Akala, Edwin Kamau
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 5, Iss 3, Pp 92-99 (2015)
Artemether–lumefantrine (AL) became the first-line treatment for uncomplicated malaria in Kenya in 2006. Studies have shown AL selects for SNPs in pfcrt and pfmdr1 genes in recurring parasites compared to the baseline infections. The genotypes asso
Externí odkaz:
https://doaj.org/article/abbbeff2eee247d5bab114bd5d409723
Autor:
Christine Wanjala, Elke Bergmann-Leitner, Hoseah M Akala, Geoffrey Odhiambo, Bernhards R Ogutu, Ben Andagalu, Edwin Kamau, Daniel Ochiel
Background Naturally acquired immunity (NAI), which is characterized by protection against overt clinical disease and high parasitaemia, is acquired with age and transmission intensity. The role of NAI on the efficacy of anti-malarial drugs, includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0365c3c9a7edbe6baa63130be22216ae
https://doi.org/10.21203/rs.2.18722/v1
https://doi.org/10.21203/rs.2.18722/v1
