Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Bernhard Stockmeyer"'
Autor:
Stefan Barth, Theophilus Thepen, Judith Niesen, Fabian Philipp Kreutzer, Edgar Jost, Lea Hein, Christoph Stein, Hannes Brehm, Tim Stroisch, Dmitrij Hristodorov, Radoslav Mladenov, Rainer Fischer, Tim H. Brümmendorf, Christian Cremer, Bernhard Stockmeyer, Tobias Blume
Publikováno v:
International Journal of Cancer. 137:2729-2738
Antibody-based immunotherapy of leukemia requires the targeting of specific antigens on the surface of blasts. The Fc gamma receptor (CD64) has been investigated in detail, and CD64-targeting immunotherapy has shown promising efficacy in the targeted
Autor:
Tim H. Brümmendorf, Stefan Zwirner, Judith Niesen, Thomas Nachreiner, Christian Cremer, Gerrit Gresch, Stefan Barth, Elena Grieger, Radoslav Mladenov, Bernhard Stockmeyer, Lea Schenke, Rainer Fischer, Christoph Stein, Edgar Jost
Publikováno v:
British journal of haematology. 183(2)
Autor:
Joerg Bruenke, Matthias Peipp, Bernhard Stockmeyer, Christoph Stein, Georg H. Fey, Kristin Mentz, Heike Horner, Joerg Schubert, Michael Schwenkert, Karin Barbin, Christian Kellner
Publikováno v:
Cancer Letters. 303:128-139
Bispecific scFv antibody-derivatives (bsscFvs) recruiting natural killer (NK) cells for the lysis of malignant cells have therapeutic potential. However, a bsscFv specific for the B-lymphoid tumor antigen CD19 and the trigger molecule CD16 on NK cell
Autor:
Michael Schwenkert, Christoph Stein, Georg H. Fey, Andreas Mackensen, Fuat Oduncu, Markus Kügler, Kristin Mentz, Bernhard Stockmeyer, Ingo Schubert, Christian Kellner, Heiko Singer, Domenica Saul
Publikováno v:
British Journal of Haematology. 150:574-586
Two trivalent constructs consisting of single-chain Fv antibody fragments (scFvs) specific for the interleukin-3 receptor alpha chain (CD123), CD33 and the Fcgamma-receptor III (CD16) were designed and characterized for the elimination of acute myelo
Autor:
Georg H. Fey, Kristin Mentz, Christian Kellner, Michael Schwemmlein, Christoph Stein, Andreas Mackensen, Bernhard Stockmeyer, Harald Lanig, Heiko Singer, Michael Aigner, Fuat Oduncu
Publikováno v:
Journal of Immunotherapy. 33:599-608
Single-chain Fv triplebodies (sctb), consisting of a single polypeptide chain with 3 single-chain antibody variable fragments connected in tandem, were generated as antileukemic agents. A CD19-specific sctb of this format has previously been shown to
Autor:
Michael Dechant, Karin Barbin, Doreen Thierschmidt, Yvonne Guettinger, Thomas Valerius, Joerg Bruenke, Georg H. Fey, Matthias Peipp, Bernhard Stockmeyer, Heike Horner, Roland Repp
Publikováno v:
The Journal of Immunology. 184:1210-1217
Bispecific Abs offer new perspectives for cancer immunotherapy. In this study, we describe a recombinant bispecific single-chain fragment variable (bsscFv) directed against FcαRI (CD89) on polymorphonuclear neutrophils (PMNs) or monocytes/macrophage
Autor:
Christian Kellner, Julia Stieglmaier, Georg H. Fey, Kristin Mentz, Peter Lang, Michael Schwenkert, Michael Schwemmlein, Matthias Peipp, Bernhard Stockmeyer, Fuat Oduncu, Joerg Bruenke, Heiko Singer
Publikováno v:
Journal of Immunotherapy. 31:871-884
A novel bispecific antibody-derived recombinant protein targeting leukemias and lymphomas was designed, a single-chain Fv triple body (sctb) consisting of 1 polypeptide chain with 3 scFvs connected in tandem. The distal scFvs were specific for the tu
Autor:
Jörn-Dirk Beck, Peter Lang, Julia Stieglmaier, Georg H. Fey, F Oduncu, Matthias Peipp, Bertold Emmerich, Bernhard Stockmeyer, Domenica Saul, Christian Kellner, Michael Schwemmlein
Publikováno v:
Leukemia. 21:1405-1412
CD19 is a B-lineage-specific transmembrane signaling protein participating in the control of proliferation and differentiation. It is present at high surface density on chronic B-lymphocytic leukemia (B-CLL) cells and cells of other B-cell malignanci
Autor:
Karin Barbin, Domenica Saul, Michael Schwemmlein, Georg H. Fey, Matthias Peipp, Roland Repp, Bernhard Stockmeyer, Josef Birkmann, Fuat Oduncu, Bertold Emmerich
Publikováno v:
British Journal of Haematology. 133:141-151
A novel single-chain immunotoxin was constructed by combining a CD33-specific single chain Fv (scFv) antibody fragment with an engineered variant of Pseudomonas exotoxin A (ETA). The variant toxin carries the KDEL peptide at its C-terminus, a cellula
Autor:
Roland Repp, Thomas Valerius, Matthias Pfeiffer, Kristin Stieglmaier, Dietrich Niethammer, Peter Lang, Matthias Peipp, Bernhard Stockmeyer, Georg H. Fey, Susanne Kunert, Joerg Bruenke, Karin Barbin
Publikováno v:
British Journal of Haematology. 130:218-228
Summary A recombinant bispecific single-chain fragment variable antibody (bsscFv), directed against the B-cell antigen CD19 and the low affinity Fc-receptor FcγRIII (CD16), was designed for use in the treatment of patients with leukaemias and lympho