Somatic RIT1 delins in arteriovenous malformations hyperactivate RAS-MAPK signaling amenable to MEK inhibition.

Autor: Kapp FG; Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, VASCERN VASCA European Reference Centre, 79106, Freiburg, Germany. friedrich.kapp@uniklinik-freiburg.de., Bazgir F; Institute of Biochemistry and Molecular Biology II, Medical Faculty and University Hospital, Heinrich-Heine University, Düsseldorf, Germany., Mahammadzade N; Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, VASCERN VASCA European Reference Centre, 79106, Freiburg, Germany., Mehrabipour M; Institute of Biochemistry and Molecular Biology II, Medical Faculty and University Hospital, Heinrich-Heine University, Düsseldorf, Germany., Vassella E; Institute of Pathology and Tissue Medicine, University of Bern, Bern, Switzerland., Bernhard SM; Division of Angiology, Swiss Cardiovascular Center, Inselspital, Bern University Hospital, Bern, Switzerland.; Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland., Döring Y; Division of Angiology, Swiss Cardiovascular Center, Inselspital, Bern University Hospital, Bern, Switzerland.; Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland.; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians University Munich, Pettenkoferstr 9, 80336, Munich, Germany., Holm A; Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, VASCERN VASCA European Reference Centre, 79106, Freiburg, Germany.; Vascular Biology Program, Department of Surgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA., Karow A; Department of Pediatrics and Adolescent Medicine, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054, Erlangen, Germany., Seebauer C; Department of Otorhinolaryngology, Regensburg University Medical Center, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany., Platz Batista da Silva N; Department of Radiology, Regensburg University Medical Center, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany., Wohlgemuth WA; University Clinic and Policlinic of Radiology at the Martin-Luther-Universität Halle-Wittenberg, Halle, Germany., Oppenheimer A; Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, VASCERN VASCA European Reference Centre, 79106, Freiburg, Germany., Kröning P; Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79106, Freiburg, Germany., Niemeyer CM; Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, VASCERN VASCA European Reference Centre, 79106, Freiburg, Germany., Schanze D; Institute of Human Genetics, University Hospital Magdeburg, 39120, Magdeburg, Germany., Zenker M; Institute of Human Genetics, University Hospital Magdeburg, 39120, Magdeburg, Germany., Eng W; Division of Hematology/Oncology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA., Ahmadian MR; Institute of Biochemistry and Molecular Biology II, Medical Faculty and University Hospital, Heinrich-Heine University, Düsseldorf, Germany., Baumgartner I; Division of Angiology, Swiss Cardiovascular Center, Inselspital, Bern University Hospital, Bern, Switzerland.; Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland., Rössler J; Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, VASCERN VASCA European Reference Centre, 79106, Freiburg, Germany. jochen.roessler@insel.ch.; Department of Vascular Medicine, National Reference Center of Rare Lymphatic and Vascular Diseases, UA11 INSERM - UM IDESP, Campus Santé, Montpellier Cedex 5, France. jochen.roessler@insel.ch.; Division of Paediatric Hematology and Oncology, Department of Paediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. jochen.roessler@insel.ch.

Publikováno v: Angiogenesis [Angiogenesis] 2024 Jul 05. Date of Electronic Publication: 2024 Jul 05.

Signaling Modulation Mediated by Ligand Water Interactions with the Sodium Site at μOR.

Autor: Ople RS; Center for Clinical Pharmacology, University of Health Sciences & Pharmacy at St. Louis and Washington University School of Medicine, St. Louis, Missouri 63110, United States.; Department of Anesthesiology and Washington University Pain Center, Washington University School of Medicine, St. Louis, Missouri 63110, United States., Ramos-Gonzalez N; Center for Clinical Pharmacology, University of Health Sciences & Pharmacy at St. Louis and Washington University School of Medicine, St. Louis, Missouri 63110, United States.; Department of Anesthesiology and Washington University Pain Center, Washington University School of Medicine, St. Louis, Missouri 63110, United States., Li Q; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California 94158, United States., Sobecks BL; Department of Computer Science, Stanford University, Stanford, California 94305, United States.; Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, United States.; Department of Molecular & Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, United States., Aydin D; Department of Computer Science, Stanford University, Stanford, California 94305, United States.; Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, United States.; Department of Molecular & Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, United States., Powers AS; Department of Computer Science, Stanford University, Stanford, California 94305, United States.; Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, United States.; Department of Molecular & Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, United States., Faouzi A; Center for Clinical Pharmacology, University of Health Sciences & Pharmacy at St. Louis and Washington University School of Medicine, St. Louis, Missouri 63110, United States.; Department of Anesthesiology and Washington University Pain Center, Washington University School of Medicine, St. Louis, Missouri 63110, United States., Polacco BJ; Department of Computer Science, Stanford University, Stanford, California 94305, United States.; Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, United States., Bernhard SM; Center for Clinical Pharmacology, University of Health Sciences & Pharmacy at St. Louis and Washington University School of Medicine, St. Louis, Missouri 63110, United States.; Department of Anesthesiology and Washington University Pain Center, Washington University School of Medicine, St. Louis, Missouri 63110, United States., Appourchaux K; Center for Clinical Pharmacology, University of Health Sciences & Pharmacy at St. Louis and Washington University School of Medicine, St. Louis, Missouri 63110, United States.; Department of Anesthesiology and Washington University Pain Center, Washington University School of Medicine, St. Louis, Missouri 63110, United States., Sribhashyam S; Center for Clinical Pharmacology, University of Health Sciences & Pharmacy at St. Louis and Washington University School of Medicine, St. Louis, Missouri 63110, United States.; Department of Anesthesiology and Washington University Pain Center, Washington University School of Medicine, St. Louis, Missouri 63110, United States., Eans SO; Department of Pharmacodynamics, University of Florida, Gainesville, Florida 032610, United States., Tsai BA; Department of Pharmacodynamics, University of Florida, Gainesville, Florida 032610, United States., Dror RO; Department of Computer Science, Stanford University, Stanford, California 94305, United States.; Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, United States.; Department of Molecular & Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, United States., Varga BR; Center for Clinical Pharmacology, University of Health Sciences & Pharmacy at St. Louis and Washington University School of Medicine, St. Louis, Missouri 63110, United States.; Department of Anesthesiology and Washington University Pain Center, Washington University School of Medicine, St. Louis, Missouri 63110, United States., Wang H; Department of Molecular & Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, United States., Hüttenhain R; Department of Molecular & Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, United States., McLaughlin JP; Department of Pharmacodynamics, University of Florida, Gainesville, Florida 032610, United States., Majumdar S; Center for Clinical Pharmacology, University of Health Sciences & Pharmacy at St. Louis and Washington University School of Medicine, St. Louis, Missouri 63110, United States.; Department of Anesthesiology and Washington University Pain Center, Washington University School of Medicine, St. Louis, Missouri 63110, United States.

Publikováno v: ACS central science [ACS Cent Sci] 2024 Jul 17; Vol. 10 (8), pp. 1490-1503. Date of Electronic Publication: 2024 Jul 17 (Print Publication: 2024).

GPCR-G protein selectivity revealed by structural pharmacology.

Autor: Bernhard SM; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA.; Center for Clinical Pharmacology, University of Health Sciences & Pharmacy and Washington University School of Medicine, St. Louis, MO, USA., Han J; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA.; Center for Clinical Pharmacology, University of Health Sciences & Pharmacy and Washington University School of Medicine, St. Louis, MO, USA., Che T; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA.; Center for Clinical Pharmacology, University of Health Sciences & Pharmacy and Washington University School of Medicine, St. Louis, MO, USA.

Publikováno v: The FEBS journal [FEBS J] 2024 Jul; Vol. 291 (13), pp. 2784-2791. Date of Electronic Publication: 2024 Jan 08.

Ligand and G-protein selectivity in the κ-opioid receptor.

Autor: Han J; Department of Anesthesiology, Washington University in St Louis, St Louis, MO, USA.; Center for Clinical Pharmacology, University of Health Sciences and Pharmacy in St Louis and Washington University School of Medicine, St Louis, MO, USA., Zhang J; Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO, USA.; Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, St Louis, MO, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Nazarova AL; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA, USA.; Department of Chemistry, University of Southern California, Los Angeles, CA, USA.; Center for New Technologies in Drug Discovery and Development, Bridge Institute, Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA., Bernhard SM; Department of Anesthesiology, Washington University in St Louis, St Louis, MO, USA.; Center for Clinical Pharmacology, University of Health Sciences and Pharmacy in St Louis and Washington University School of Medicine, St Louis, MO, USA., Krumm BE; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Zhao L; Department of Anesthesiology, Washington University in St Louis, St Louis, MO, USA., Lam JH; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA, USA.; Department of Chemistry, University of Southern California, Los Angeles, CA, USA.; Center for New Technologies in Drug Discovery and Development, Bridge Institute, Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA., Rangari VA; Center for Clinical Pharmacology, University of Health Sciences and Pharmacy in St Louis and Washington University School of Medicine, St Louis, MO, USA., Majumdar S; Department of Anesthesiology, Washington University in St Louis, St Louis, MO, USA.; Center for Clinical Pharmacology, University of Health Sciences and Pharmacy in St Louis and Washington University School of Medicine, St Louis, MO, USA.; Washington University Pain Center, Washington University in St Louis, St Louis, MO, USA., Nichols DE; Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA., Katritch V; Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA, USA.; Department of Chemistry, University of Southern California, Los Angeles, CA, USA.; Center for New Technologies in Drug Discovery and Development, Bridge Institute, Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA., Yuan P; Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO, USA.; Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine, St Louis, MO, USA.; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Fay JF; Department of Biochemistry and Molecular Biology, University of Maryland Baltimore, Baltimore, MD, USA. jfay@som.umaryland.edu., Che T; Department of Anesthesiology, Washington University in St Louis, St Louis, MO, USA. taoche@wustl.edu.; Center for Clinical Pharmacology, University of Health Sciences and Pharmacy in St Louis and Washington University School of Medicine, St Louis, MO, USA. taoche@wustl.edu.; Washington University Pain Center, Washington University in St Louis, St Louis, MO, USA. taoche@wustl.edu.

Publikováno v: Nature [Nature] 2023 May; Vol. 617 (7960), pp. 417-425. Date of Electronic Publication: 2023 May 03.

Molecular mechanism of biased signaling at the kappa opioid receptor.

Autor: El Daibani A; Department of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, USA.; Center for Clinical Pharmacology, University of Health Sciences & Pharmacy and Washington University School of Medicine, Saint Louis, MO, USA., Paggi JM; Department of Computer Science, Stanford University, Stanford, CA, USA., Kim K; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.; Department of Pharmacy, Yonsei University, Incheon, 21983, Republic of Korea., Laloudakis YD; Department of Computer Science, Stanford University, Stanford, CA, USA., Popov P; iMolecule, Skolkovo Institute of Science and Technology, Moscow, Russia., Bernhard SM; Department of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, USA.; Center for Clinical Pharmacology, University of Health Sciences & Pharmacy and Washington University School of Medicine, Saint Louis, MO, USA., Krumm BE; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Olsen RHJ; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Diberto J; Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, NC, USA., Carroll FI; Research Triangle Institute, P.O. Box 12194, Research Triangle Park, NC, 27709, USA., Katritch V; Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA., Wünsch B; Institut für Pharmazeutische und Medizinische Chemie, Universität Münster, Corrensstraße 48, 48149, Münster, Germany., Dror RO; Department of Computer Science, Stanford University, Stanford, CA, USA. ron.dror@stanford.edu.; Departments of Molecular and Cellular Physiology and of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA. ron.dror@stanford.edu., Che T; Department of Anesthesiology, Washington University School of Medicine, Saint Louis, MO, USA. taoche@wustl.edu.; Center for Clinical Pharmacology, University of Health Sciences & Pharmacy and Washington University School of Medicine, Saint Louis, MO, USA. taoche@wustl.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Mar 11; Vol. 14 (1), pp. 1338. Date of Electronic Publication: 2023 Mar 11.