Structure of the major carrot allergen {Dau c 1}

Autor: Arnaud Baslé, Zora Marković-Housley, Karin Hoffmann-Sommergruber, Sivaraman Padavattan, Bernhard Maderegger, Tilman Schirmer

Publikováno v: Acta Crystallogr. D Biol. Crystallogr.

Dau c 1 is a major allergen of carrot ( Daucus carota) which displays IgE cross-reactivity with the homologous major birch-pollen allergen Bet v 1. The crystal structure of Dau c 1 has been determined to a resolution of 2.7 angstrom, revealing tight

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d23fd11314643c1d27f4d4b8118a3dba

Development of a hypoallergenic recombinant parvalbumin for first-in-man subcutaneous immunotherapy of fish allergy

Autor: Suzanne Quaak, Marianne Witten, Birgit Linhart, E. N. Clare Mills, Bernhard Maderegger, Neil M. Rigby, Ines Swoboda, Jet Heyse, Antonio Portolés, Jaap H. Akkerdaas, Rudolf Valenta, Sonia Vázquez-Cortés, Per Stahl-Skov, Anna Lewandowska-Polak, Lars Blom, Sara Santos-Magadan, Laurian Zuidmeer-Jongejan, Frank Stolz, Carsten Bindslev-Jensen, Heidi J. Schnoor, Rosa Ferrara, Sigurveig T. Sigurdardottir, Juan A. Asturias, Bernard Maillere, Michael Clausen, Maria Livia Bernardi, Georg Stegfellner, George A. Stavroulakis, Montserrat Fernandez-Rivas, Stephan Kopp, Lars K. Poulsen, Ville Ranta-Panula, Ronald van Ree, Claudio Nicoletti, Nikolaos G. Papadopoulos, Adriano Mari, Martina Hauer, Bettina M. Jensen, Angela Neubauer, Hans Huber, Alberto Martínez, Serge A. Versteeg, Marek L. Kowalski

Publikováno v: International archives of allergy and immunology, 166(1), 41-51. S. Karger AG
Zuidmeer-Jongejan, L, Huber, H, Swoboda, I, Rigby, N, Versteeg, S A, Jensen, B M, Quaak, S, Akkerdaas, J H, Blom, L, Asturias, J, Bindslev-Jensen, C, Bernardi, M L, Clausen, M, Ferrara, R, Hauer, M, Heyse, J, Kopp, S, Kowalski, M L, Lewandowska-Polak, A, Linhart, B, Maderegger, B, Maillere, B, Mari, A, Martinez, A, Mills, E N C, Neubauer, A, Nicoletti, C, Papadopoulos, N G, Portoles, A, Ranta-Panula, V, Santos-Magadan, S, Schnoor, H J, Sigurdardottir, S T, Stahl-Skov, P, Stavroulakis, G, Stegfellner, G, Vázquez-Cortés, S, Witten, M, Stolz, F, Poulsen, L K, Fernandez-Rivas, M, Valenta, R & van Ree, R 2015, ' Development of a hypoallergenic recombinant parvalbumin for first-in-man subcutaneous immunotherapy of fish allergy ', International Archives of Allergy and Immunology, vol. 166, no. 1, pp. 41-51 . https://doi.org/10.1159/000371657

Background: The FAST (food allergy-specific immunotherapy) project aims at developing safe and effective subcutaneous immunotherapy for fish allergy, using recombinant hypoallergenic carp parvalbumin, Cyp c 1. Objectives: Preclinical characterization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc066341d280b23515e2f881dbe10e49
http://hdl.handle.net/2158/1093596

Altered IgE epitope presentation: A model for hypoallergenic activity revealed for Bet v 1 trimer

Autor: Margarete Focke-Tejkl, Susanne Spitzauer, Josef Thalhamer, Ines Swoboda, Katharina Blatt, Harald Herrmann, Susanne Vrtala, Domen Zafred, Peter Valent, Anna Gieras, Rudolf Valenta, Yuliya Dall’Antonia, Walter Keller, Raffaela Campana, Bernhard Maderegger, Sandra Scheiblhofer, Angela Neubauer

Publikováno v: Molecular immunology. 48(4)

In order to reduce side effects in the course of allergen specific immunotherapy hypoallergenic allergen derivatives with reduced IgE reactivity have been made by genetic engineering. In contrast to other recombinant hypoallergenic allergen derivativ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af79beda1d63e89e8807bac386b929f
https://pubmed.ncbi.nlm.nih.gov/21093057

In vitro analysis of birch-pollen-associated food allergy by use of recombinant allergens in the basophil activation test

Autor: I. Sauer, Stephan Erdmann, R. Kwiecien, B. Sachs, S. Moll-Slodowy, H.F. Merk, Karin Hoffmann-Sommergruber, Bernhard Maderegger, A. Schmidt, Otto Scheiner

Publikováno v: International archives of allergy and immunology. 136(3)

Background: Basophil activation is associated with the expression of CD63. In birch-pollen-associated food allergy to celery, carrot and apple, Bet v 1, Api g 1, Dau c 1 and Mal d 1 are major allergens. Recombinant allergens have not yet been used in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd6aaa077d8f7e0340763a5ba722386
https://pubmed.ncbi.nlm.nih.gov/15713985

Hypoallergenic derivatives of the major birch pollen allergen Bet v 1 obtained by rational sequence reassembly

Autor: Margarete Focke-Tejkl, Ines Swoboda, Rudolf Valenta, Peter Jertschin, Walter Keller, Domen Zafred, Raffaela Campana, Susanne Spitzauer, Gottfried Stegfellner, Katharina Blatt, Angela Neubauer, Peter Valent, Bernhard Maderegger, Susanne Vrtala, Anna Gieras

Publikováno v: Publons
Europe PubMed Central
ResearcherID

Background At least 100 million patients suffer from birch pollen allergy. Objective Rational design of recombinant derivatives of the major birch pollen allergen, Bet v 1, characterized by reduced IgE reactivity, preservation of sequences relevant f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b5dfd668f031107e5a56305b627ca6
https://publons.com/publon/48978825/