Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Bernhard Luscher"'
Autor:
Anton V. Malyshev, Iuliia A. Sukhanova, Alexander S. Zlobin, Vasilina R. Gedzun, Vsevolod V. Pavshintsev, Ekaterina V. Vasileva, Arthur O. Zalevsky, Igor I. Doronin, Nikita A. Mitkin, Andrey V. Golovin, Maxim L. Lovat, Georgy I. Kovalev, Yurii A. Zolotarev, Askar R. Kuchumov, Gennady A. Babkin, Bernhard Luscher
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
The aim of the study was to develop better anxiolytics and antidepressants. We focused on GABAA receptors and the α2δ auxiliary subunit of V-gated Ca2+ channels as putative targets because they are established as mediators of efficacious anxiolytic
Externí odkaz:
https://doaj.org/article/744533a44c374b5489533f40fc433b89
Publikováno v:
Neurobiology of Stress, Vol 13, Iss , Pp 100238- (2020)
Chronic stress represents a vulnerability factor for anxiety and depressive disorders and has been widely used to model aspects of these disorders in rodents. Disinhibition of somatostatin (SST)-positive GABAergic interneurons in mice by deletion of
Externí odkaz:
https://doaj.org/article/b8ff3d2bcb774c04947f58760c19f5b0
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e47441 (2012)
Vulnerability for anxiety and depressive disorders is thought to have origins in early life and is increasingly recognized to involve deficits in GABAergic neurotransmission. Mice that were rendered heterozygous for the γ2 subunit gene of GABA(A) re
Externí odkaz:
https://doaj.org/article/cf7b0fe0c1fe4feb99455aa175b45c27
Autor:
Werner Sieghart, Uwe Rudolph, John A. Peters, Richard Olsen, Bernhard Luscher, Jeremy J. Lambert, Tim G. Hales, Delia Belelli
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
The GABAA receptor is a ligand-gated ion channel of the Cys-loop family that includes the nicotinic acetylcholine, 5-HT3 and strychnine-sensitive glycine receptors. GABAA receptor-mediated inhibition within the CNS occurs by fast synaptic transmissio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27f734d6fc75583e9ad1e9df611399fc
https://doi.org/10.2218/gtopdb/f72/2023.1
https://doi.org/10.2218/gtopdb/f72/2023.1
Publikováno v:
Advances in pharmacology (San Diego, Calif.). 89
There has been much recent progress in understanding of the mechanism of ketamine's rapid and enduring antidepressant effects. Here we review recent insights from clinical and preclinical studies, with special emphasis of ketamine-induced changes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bb527ac389f632c4cf824294944d703e
https://pubmed.ncbi.nlm.nih.gov/32616214
https://pubmed.ncbi.nlm.nih.gov/32616214
Autor:
Mirna Barsoum, Roksaneh Sayadi-Boroujeni, Alexander T. Stenzel, Philip Bussmann, Juliane Lüscher-Firzlaff, Bernhard Lüscher
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-21 (2023)
Abstract The trithorax protein ASH2L is essential for organismal and tissue development. As a subunit of COMPASS/KMT2 complexes, ASH2L is necessary for methylation of histone H3 lysine 4 (H3K4). Mono- and tri-methylation at this site mark active enha
Externí odkaz:
https://doaj.org/article/88206fdb0f804739b4fd150f29c244b8
Autor:
Mirna Barsoum, Alexander T. Stenzel, Agnieszka Bochyńska, Chao-Chung Kuo, Alexander Tsompanidis, Roksaneh Sayadi-Boroujeni, Philip Bussmann, Juliane Lüscher-Firzlaff, Ivan G. Costa, Bernhard Lüscher
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Changes in gene expression programs are intimately linked to cell fate decisions. Post-translational modifications of core histones contribute to control gene expression. Methylation of lysine 4 of histone H3 (H3K4) correlates with active pr
Externí odkaz:
https://doaj.org/article/945f11ec52004d7ebe0c874a7494f3b5
Publikováno v:
The Journal of physiology. 577(Pt 2)
Deficits in GABAergic inhibitory transmission are a hallmark of temporal lobe epilepsy and have been replicated in animal and tissue culture models of epilepsy. GABAergic inhibition comprises phasic and tonic inhibition that is mediated by synaptic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e61df7a379a6d72bc13039676d7945ed
https://pubmed.ncbi.nlm.nih.gov/16990405
https://pubmed.ncbi.nlm.nih.gov/16990405
Autor:
Catherine, Pannell, Sharon X, Simonian, Glenda E, Gillies, Bernhard, Luscher, Allan E, Herbison
Publikováno v:
Neuroendocrinology. 76(2)
Gonadal steroids exert an important regulatory influence upon the biosynthetic and secretory activity of the somatostatin and growth hormone-releasing hormone (GHRH) neurons controlling the release of growth hormone. It is hypothesized that some of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8f52cebaec42fde343d7604a2189ba83
https://pubmed.ncbi.nlm.nih.gov/12169770
https://pubmed.ncbi.nlm.nih.gov/12169770