Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Bernhard Gutmann"'
Autor:
Bernhard Gutmann, Toma N. Glasnov, Tahseen Razzaq, Walter Goessler, Dominique M. Roberge, C. Oliver Kappe
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 7, Iss 1, Pp 503-517 (2011)
The decomposition of 5-benzhydryl-1H-tetrazole in an N-methyl-2-pyrrolidone/acetic acid/water mixture was investigated under a variety of high-temperature reaction conditions. Employing a sealed Pyrex glass vial and batch microwave conditions at 240
Externí odkaz:
https://doaj.org/article/06d08e2244f044f8a40cd660996bbe62
Autor:
Olivier Hannaerts, Dominique M. Roberge, Brendon J. Doyle, Petteri Elsner, Bernhard Gutmann, Christof Aellig, Arturo Macchi
Publikováno v:
Organic Process Research & Development. 24:2169-2182
Pharmaceutical production has historically relied on multipurpose batch vessels in order to produce material through scheduled production campaigns. Although this method is flexible, it is becoming...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c2ffab7eee5a45dcc6916f5306babf6
https://doi.org/10.1021/acs.oprd.0c00207
https://doi.org/10.1021/acs.oprd.0c00207
Autor:
Arturo Macchi, Dominique M. Roberge, Michael Bittel, Brendon J. Doyle, Bernhard Gutmann, Thierry Hubler
Publikováno v:
Industrial & Engineering Chemistry Research. 59:4007-4019
The solid handling ability and flow patterns of a baffleless oscillatory flow coil reactor are investigated and characterized. Previous works in oscillatory flow have been generally conducted in st...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbbf3ed61a2ddaff6e02a903fe7353fe
https://doi.org/10.1021/acs.iecr.9b04496
https://doi.org/10.1021/acs.iecr.9b04496
Publikováno v:
Chemcatchem
The development of a continuous‐flow protocol for a palladium‐catalyzed methoxycarbonylation of (hetero)aryl chlorides using carbon monoxide gas and methanol is described. (Hetero)aryl chlorides are the least expensive of the aryl halides, but ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34105ffa76a1121ed6f7d6788df6fbf
http://europepmc.org/articles/PMC6813631
http://europepmc.org/articles/PMC6813631
Publikováno v:
Accounts of Chemical Research
Conspectus In recent years, a steadily growing number of chemists, from both academia and industry, have dedicated their research to the development of continuous flow processes performed in milli- or microreactors. The common availability of continu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369d6630ad7add28160f6fe3fc04ce1a
https://pubmed.ncbi.nlm.nih.gov/32543830
https://pubmed.ncbi.nlm.nih.gov/32543830
Autor:
Bernhard Gutmann, C. Oliver Kappe, Paul Hanselmann, Christopher A. Hone, Michael Bersier, Ana Torvisco, Manuel Köckinger
Publikováno v:
Organic Process Research & Development. 22:1553-1563
The development of a scalable telescoped continuous flow procedure for difluoromethylation of a protected amino acid with fluoroform (CHF3, R-23) gas and subsequent high temperature deprotection to provide eflornithine, an important Active Pharmaceut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f26af312236da1faf9a03b152acdbe13
https://doi.org/10.1021/acs.oprd.8b00318
https://doi.org/10.1021/acs.oprd.8b00318
Autor:
Manuel Köckinger, Paul Hanselmann, C. Oliver Kappe, Bernhard Gutmann, Michael Bersier, Tanja Ciaglia
Publikováno v:
Green Chemistry. 20:108-112
Fluoroform (CHF3) can be considered as an ideal reagent for difluoromethylation reactions. However, due to the low reactivity of fluoroform, only very few applications have been reported so far. Herein we report a continuous flow difluoromethylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1659ef89efe229d101182832fa4b0a61
https://doi.org/10.1039/c7gc02913f
https://doi.org/10.1039/c7gc02913f
Autor:
C. Oliver Kappe, Bernhard Gutmann
Publikováno v:
Journal of Flow Chemistry. 7:65-71
Optimizing current chemical processes alone does not yield the improvements required in the fine chemical and pharmaceutical industries. At least partially, a switch from batch to continuous manufacturing is needed. Cost-, time-, and atom-efficient r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b53d7ed5bb0cd92b0c05cb4c67dc744c
https://doi.org/10.1556/1846.2017.00009
https://doi.org/10.1556/1846.2017.00009
Publikováno v:
European Journal of Organic Chemistry. 2017:6511-6517
Herein we report a convenient, fast, and high-yielding method for the generation of the racemic amide anaesthetics mepivacaine, ropivacaine, and bupivacaine. Coupling of α-picolinic acid and 2,6-xylidine under sealed-vessel microwave conditions gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9ea76948fcb489f62877ec8d579f860
https://doi.org/10.1002/ejoc.201700824
https://doi.org/10.1002/ejoc.201700824
Publikováno v:
Organic Process Research & Development. 21:1080-1087
A continuous-flow Pd-catalyzed oxidative carbonylation protocol utilizing CO and O2 gas for the synthesis of carbonylated heterocycles is described. The optimization of temperature, pressure, CO/O2 ratio, catalyst loading, and reaction time resulted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce7779d39283abda5a9e2ad04fd50a75
https://doi.org/10.1021/acs.oprd.7b00217
https://doi.org/10.1021/acs.oprd.7b00217