Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Bernhard F. Gibbs"'
Autor:
Stephanie Schlichtner, Inna M. Yasinska, Elena Klenova, Maryam Abooali, Gurprit S. Lall, Steffen M. Berger, Sabrina Ruggiero, Dietmar Cholewa, Milan Milošević, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTMalignant tumors often escape anticancer immune surveillance by suppressing the cytotoxic functions of T lymphocytes. While many of these immune evasion networks include checkpoint proteins, small molecular weight compounds, such as the amino
Externí odkaz:
https://doaj.org/article/af8e958bbeec46739a4b45819fd24cbb
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/63fed4272cb04f45843c9bbf8fa3422e
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
Basophils crucially contribute to allergies and other Th2-driven diseases by rapidly releasing inflammatory and immunomodulatory mediators following high-affinity IgE-receptor crosslinking. Although these basophil-mediated responses depend on sensiti
Externí odkaz:
https://doaj.org/article/b43da17b1e10421fa90919f92a8c7df8
Autor:
Gaetan Aime Noubissi Nzeteu, Bernhard F. Gibbs, Nika Kotnik, Achim Troja, Maximilian Bockhorn, N. Helge Meyer
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Pancreatic cancer (PC) has a complex and unique tumor microenvironment (TME). Due to the physical barrier formed by the desmoplastic stroma, the delivery of drugs to the tumor tissue is limited. The TME also contributes to resistance to various immun
Externí odkaz:
https://doaj.org/article/475189f468f740958d6e4c8a987b8398
Autor:
Gaetan Aime Noubissi Nzeteu, Stephanie Schlichtner, Sulamith David, Aylin Ruppenstein, Elizaveta Fasler-Kan, Ulrike Raap, Vadim V. Sumbayev, Bernhard F. Gibbs, N. Helge Meyer
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Recently, the V-domain immunoglobulin suppressor of T-cell activation (VISTA) was identified as a negative immune checkpoint regulator (NCR) that is mainly expressed in hematopoietic cells. Preclinical studies have shown that VISTA blockade results i
Externí odkaz:
https://doaj.org/article/efc8ca0dc2af46be88b2cef44b04ee93
Autor:
Stephanie Schlichtner, Inna M. Yasinska, Sabrina Ruggiero, Steffen M. Berger, Nijas Aliu, Mateja Prunk, Janko Kos, N. Helge Meyer, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Immune checkpoint proteins play crucial roles in human embryonic development but are also used by cancer cells to escape immune surveillance. These proteins and biochemical pathways associated with them form a complex machinery capable of blocking th
Externí odkaz:
https://doaj.org/article/df9cbb22cd0c4b25850127b6e31a3396
Autor:
Anette Teo Hansen Selnø, Stephanie Schlichtner, Inna M. Yasinska, Svetlana S. Sakhnevych, Walter Fiedler, Jasmin Wellbrock, Steffen M. Berger, Elena Klenova, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
High mobility group box 1 (HMGB1) is a non-histone protein which is predominantly localised in the cell nucleus. However, stressed, dying, injured or dead cells can release this protein into the extracellular matrix passively. In addition, HMGB1 rele
Externí odkaz:
https://doaj.org/article/c04a7804921742bfb246d9e415af1d0d
Autor:
Inna M. Yasinska, N. Helge Meyer, Stephanie Schlichtner, Rohanah Hussain, Giuliano Siligardi, Maxwell Casely-Hayford, Walter Fiedler, Jasmin Wellbrock, Cloe Desmet, Luigi Calzolai, Luca Varani, Steffen M. Berger, Ulrike Raap, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Acute myeloid leukemia (AML), a blood/bone marrow cancer, is a severe and often fatal malignancy. AML cells are capable of impairing the anti-cancer activities of cytotoxic lymphoid cells. This includes the inactivation of natural killer (NK) cells a
Externí odkaz:
https://doaj.org/article/fde3b7a88f6a40a58578f302b9d89082
Autor:
Urda Rüdrich, Manuela Gehring, Eleni Papakonstantinou, Anja Illerhaus, Judith Engmann, Alexander Kapp, Karin Hartmann, N. Helge Meyer, Bernhard F. Gibbs, Ulrike Raap
Publikováno v:
Acta Dermato-Venereologica, Vol 98, Iss 8, Pp 766-771 (2018)
Bullous pemphigoid (BP) is characterized by substantial skin and blood eosinophilia as well as intensive pruritus. Since the pruritogenic cytokine interleukin (IL)-31 is increased in inflammatory skin diseases the aim of this study was to determine w
Externí odkaz:
https://doaj.org/article/8879b514222241059e0b98ead137c964
Autor:
Isabel Gonçalves Silva, Inna M. Yasinska, Svetlana S. Sakhnevych, Walter Fiedler, Jasmin Wellbrock, Marco Bardelli, Luca Varani, Rohanah Hussain, Giuliano Siligardi, Giacomo Ceccone, Steffen M. Berger, Yuri A. Ushkaryov, Bernhard F. Gibbs, Elizaveta Fasler-Kan, Vadim V. Sumbayev
Publikováno v:
EBioMedicine, Vol 22, Iss C, Pp 44-57 (2017)
Acute myeloid leukemia (AML) is a severe and often fatal systemic malignancy. Malignant cells are capable of escaping host immune surveillance by inactivating cytotoxic lymphoid cells. In this work we discovered a fundamental molecular pathway, which
Externí odkaz:
https://doaj.org/article/e004d7f74c5c43a19b8c11d1701ce852