Zobrazeno 1 - 10
of 411
pro vyhledávání: '"Bernhard, Nieswandt"'
Autor:
Ophélie Le Chapelain, Soumaya Jadoui, Angèle Gros, Samir Barbaria, Keltouma Benmeziane, Véronique Ollivier, Sébastien Dupont, Mialitiana Solo Nomenjanahary, Sabrina Mavouna, Jasmina Rogozarski, Marie-Anne Mawhin, Giuseppina Caligiuri, Sandrine Delbosc, Françoise Porteu, Bernhard Nieswandt, Pierre H Mangin, Yacine Boulaftali, Benoit Ho-Tin-Noé
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-16 (2024)
Abstract Background How platelets interact with and influence the tumor microenvironment (TME) remains poorly characterized. Methods We compared the presence and participation of platelets in the TME of two tumors characterized by highly different TM
Externí odkaz:
https://doaj.org/article/8253c65b18f54a898e53bd7f3b37bc97
Autor:
Andreas Starke, Alexander M. Kollikowski, Vivian Vogt, Guido Stoll, Bernhard Nieswandt, Mirko Pham, David Stegner, Michael K. Schuhmann
Publikováno v:
Biomedicines, Vol 12, Iss 10, p 2191 (2024)
Background: Severe acute ischemic stroke (AIS) is mainly caused by thromboembolism originating from symptomatic carotid artery (ICA) stenosis or in the heart due to atrial fibrillation. Glycoprotein VI (GPVI), a principal platelet receptor, facilitat
Externí odkaz:
https://doaj.org/article/f668caeb58f740a484fde12cd765f6f1
Autor:
Till Karwen, Katarzyna Kolczynska‐Matysiak, Carina Gross, Mona C Löffler, Mike Friedrich, Angel Loza‐Valdes, Werner Schmitz, Magdalena Wit, Filip Dziaczkowski, Andrei Belykh, Jonathan Trujillo‐Viera, Rabih El‐Merahbi, Carsten Deppermann, Sameena Nawaz, Benoit Hastoy, Agnieszka Demczuk, Manuela Erk, Mariusz R Wieckowski, Patrik Rorsman, Katrin G Heinze, David Stegner, Bernhard Nieswandt, Grzegorz Sumara
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 9, Pp 1-23 (2023)
Abstract Hyperreactive platelets are commonly observed in diabetic patients indicating a potential link between glucose homeostasis and platelet reactivity. This raises the possibility that platelets may play a role in the regulation of metabolism. P
Externí odkaz:
https://doaj.org/article/974cd37e10194d4682e8df439ae20f8d
Autor:
Xiaojuan Zhao, Dominic Alibhai, Tony G. Walsh, Nathalie Tarassova, Maximilian Englert, Semra Z. Birol, Yong Li, Christopher M. Williams, Chris R. Neal, Philipp Burkard, Stephen J. Cross, Elizabeth W. Aitken, Amie K. Waller, José Ballester Beltrán, Peter W. Gunning, Edna C. Hardeman, Ejaife O. Agbani, Bernhard Nieswandt, Ingeborg Hers, Cedric Ghevaert, Alastair W. Poole
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Platelets, small hemostatic blood cells, are derived from megakaryocytes. Both bone marrow and lung are principal sites of thrombopoiesis although underlying mechanisms remain unclear. Outside the body, however, our ability to generate large
Externí odkaz:
https://doaj.org/article/b34379c46b594e3991173e9d3c71b0ac
Autor:
Yvonne Schurr, Lucy Reil, Markus Spindler, Bernhard Nieswandt, Laura M. Machesky, Markus Bender
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract The platelet specific integrin αIIbβ3 mediates platelet adhesion, aggregation and plays a central role in thrombosis and hemostasis. In resting platelets, αIIbβ3 is expressed on the membrane surface and in intracellular compartments. Upo
Externí odkaz:
https://doaj.org/article/7ef824ac8fb24d149eddb056af115eba
Publikováno v:
Platelets, Vol 34, Iss 1 (2023)
Circulating platelets maintain low cytosolic Ca2+ concentrations. At sites of vascular injury, agonist-induced Ca2+ release from platelet intracellular stores triggers influx of extracellular Ca2+, a process known as store-operated Ca2+ entry (SOCE).
Externí odkaz:
https://doaj.org/article/f66e7dc148964a8e82a878d455bd4c95
Autor:
Joanne C. Clark, Eleyna M. Martin, Luis A. Morán, Ying Di, Xueqing Wang, Malou Zuidscherwoude, Helena C. Brown, Deirdre M. Kavanagh, Johan Hummert, Johannes A. Eble, Bernhard Nieswandt, David Stegner, Alice Y. Pollitt, Dirk-Peter Herten, Michael G. Tomlinson, Angel García, Steve P. Watson
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
Fluorescence correlation spectroscopy on crosslinked nanobodies tested on C-type lectin-like receptor 2 (CLEC-2) show different outcomes for divalent and tetravalent nanobody ligands on CLEC-2 clustering, also dependent on CLEC-2 expression levels.
Externí odkaz:
https://doaj.org/article/7459f6954fe94e3e8043691e4c0d8e5b
Autor:
David Ascheid, Magdalena Baumann, Caroline Funke, Julia Volz, Jürgen Pinnecker, Mike Friedrich, Marie Höhn, Rajender Nandigama, Süleyman Ergün, Bernhard Nieswandt, Katrin G. Heinze, Erik Henke
Publikováno v:
Biology Direct, Vol 18, Iss 1, Pp 1-15 (2023)
Abstract In tumor therapy anti-angiogenic approaches have the potential to increase the efficacy of a wide variety of subsequently or co-administered agents, possibly by improving or normalizing the defective tumor vasculature. Successful implementat
Externí odkaz:
https://doaj.org/article/b1a63164057a41fda92985124212471c
Autor:
Helene A. Haeberle, Stefanie Calov, Peter Martus, Lina Maria Serna-Higuita, Michael Koeppen, Almuth Goll, Alice Bernard, Alexander Zarbock, Melanie Meersch, Raphael Weiss, Martin Mehrländer, Gernot Marx, Christian Putensen, Tamam Bakchoul, Harry Magunia, Bernhard Nieswandt, Valbona Mirakaj, Peter Rosenberger
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-11 (2023)
Abstract Background Acute respiratory distress syndrome (ARDS) results in significant hypoxia, and ARDS is the central pathology of COVID-19. Inhaled prostacyclin has been proposed as a therapy for ARDS, but data regarding its role in this syndrome a
Externí odkaz:
https://doaj.org/article/b90bd6e37cc64ef991e475ec1d9c972e
Autor:
Amro Elgheznawy, Patricia Öftering, Maximilian Englert, Kristina Mott, Friederike Kaiser, Charly Kusch, Uwe Gbureck, Michael R. Bösl, Harald Schulze, Bernhard Nieswandt, Timo Vögtle, Heike M. Hermanns
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Zinc (Zn2+) is considered as important mediator of immune cell function, thrombosis and haemostasis. However, our understanding of the transport mechanisms that regulate Zn2+ homeostasis in platelets is limited. Zn2+ transporters, ZIPs and ZnTs, are
Externí odkaz:
https://doaj.org/article/910106bae0214b969371100e54cf7a15