Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Bernhard, Loll"'
Autor:
Philipp K. Zuber, Nelly Said, Tarek Hilal, Bing Wang, Bernhard Loll, Jorge González-Higueras, César A. Ramírez-Sarmiento, Georgiy A. Belogurov, Irina Artsimovitch, Markus C. Wahl, Stefan H. Knauer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract RfaH, a paralog of the universally conserved NusG, binds to RNA polymerases (RNAP) and ribosomes to activate expression of virulence genes. In free, autoinhibited RfaH, an α-helical KOW domain sequesters the RNAP-binding site. Upon recruitm
Externí odkaz:
https://doaj.org/article/22619a1bbf0f4160960efd35b3c7e5a0
Autor:
Junqiao Jia, Tarek Hilal, Katherine E. Bohnsack, Aleksandar Chernev, Ning Tsao, Juliane Bethmann, Aruna Arumugam, Lane Parmely, Nicole Holton, Bernhard Loll, Nima Mosammaparast, Markus T. Bohnsack, Henning Urlaub, Markus C. Wahl
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
ASCC3 is a multi-functional helicase that contains two consecutive Ski2-like helicase units. Here, the authors show that ASCC3 can unwind DNA by threading one strand of a substrate duplex through both helicase units, supported by the TRIP4 protein.
Externí odkaz:
https://doaj.org/article/0ee2586a4c9f44dfb7f3b09d1b9bc981
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 18, Iss 1, Pp 972-978 (2022)
Terpene synthases are responsible for the biosynthesis of terpenes, the largest family of natural products. Hydropyrene synthase generates hydropyrene and hydropyrenol as its main products along with two byproducts, isoelisabethatrienes A and B. Fasc
Externí odkaz:
https://doaj.org/article/67311a32c2ff4c6394dfa53e5e97b569
Autor:
Viviane Kremling, Bernhard Loll, Szymon Pach, Ismail Dahmani, Christoph Weise, Gerhard Wolber, Salvatore Chiantia, Markus C. Wahl, Nikolaus Osterrieder, Walid Azab
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Cell entry of most alphaherpesviruses is mediated by the binding of glycoprotein D (gD) to different cell surface receptors. Equine herpesvirus type 1 (EHV-1) and EHV-4 gDs interact with equine major histocompatibility complex I (MHC-I) to initiate e
Externí odkaz:
https://doaj.org/article/3f383c03112646479d3bee13a5b7a488
Autor:
Marion Ringel, Nicole Dimos, Stephanie Himpich, Martina Haack, Claudia Huber, Wolfgang Eisenreich, Gerhard Schenk, Bernhard Loll, Thomas Brück
Publikováno v:
Microbial Cell Factories, Vol 21, Iss 1, Pp 1-15 (2022)
Abstract Background Terpene synthases are versatile catalysts in all domains of life, catalyzing the formation of an enormous variety of different terpenoid secondary metabolites. Due to their diverse bioactive properties, terpenoids are of great int
Externí odkaz:
https://doaj.org/article/e708d05bfff546cabca72f85a608594b
Autor:
Tam Dang, Bernhard Loll, Sebastian Müller, Ranko Skobalj, Julia Ebeling, Timur Bulatov, Sebastian Gensel, Josefine Göbel, Markus C. Wahl, Elke Genersch, Andi Mainz, Roderich D. Süssmuth
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The authors show that the N-acetyltransferase PamZ acts as a self-resistance factor disabling the antibacterial paenilamicin that is produced by the honey bee larvae pathogen Paenibacillus larvae.
Externí odkaz:
https://doaj.org/article/efd0e34fbaa048d5bbc9b3660ecfcfae
Autor:
Sophia Prem, Carl P. O. Helmer, Nicole Dimos, Stephanie Himpich, Thomas Brück, Daniel Garbe, Bernhard Loll
Publikováno v:
Microbial Cell Factories, Vol 21, Iss 1, Pp 1-15 (2022)
Abstract Fatty acid hydratases are unique to microorganisms. Their native function is the oxidation of unsaturated C–C bonds to enable detoxification of environmental toxins. Within this enzyme family, the oleate hydratases (Ohys), which catalyze t
Externí odkaz:
https://doaj.org/article/edc61b82d2c946f284242cb6d1614e4d
Autor:
Huan Lan, Esam T. Abualrous, Jana Sticht, Laura Maria Arroyo Fernandez, Tamina Werk, Christoph Weise, Martin Ballaschk, Peter Schmieder, Bernhard Loll, Christian Freund
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Tapasin is part of the peptide loading complex necessary for presenting antigenic peptides on MHC-I for the induction of adaptive immunity. Here the authors show that tapasin interacts with MHC-I in both conserved and allele-specific regions to promo
Externí odkaz:
https://doaj.org/article/8bd32bbbde944e95a968d72ae29445ed
Autor:
Hao-Hong Pei, Tarek Hilal, Zhuo A. Chen, Yong-Heng Huang, Yuan Gao, Nelly Said, Bernhard Loll, Juri Rappsilber, Georgiy A. Belogurov, Irina Artsimovitch, Markus C. Wahl
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The bacterial helicase-like transcription factor HelD interacts with the RNA polymerase (RNAP) and together with the RNAP δ subunit enhances RNAP cycling. Here, the authors present the cryo-EM structures of the monomeric and dimeric Bacillus subtili
Externí odkaz:
https://doaj.org/article/862de4900b514335855420b64fe9f8ae
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1819-1829 (2020)
While chemical steps involved in bioactive cembranoid biosynthesis have been examined, the corresponding enzymatic mechanisms leading to their formation remain elusive. In the tobacco plant, Nicotiana tabacum, a putative cembratriene-ol synthase (CBT
Externí odkaz:
https://doaj.org/article/5a71158715b24d4aad53049735762927