Zobrazeno 1 - 10
of 268
pro vyhledávání: '"Bernhard, Bettler"'
Autor:
Noa Bielopolski, Michal Stawarski, Ilana Roitman, Karen Fridman, Shane Wald-Altman, Simon Früh, Bernhard Bettler, Andreea Nissenkorn
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
GABAB receptors (GABABRs) are G protein-coupled receptors for γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system. Pathogenic variants in the GABBR1 and GABBR2 genes, which encode the GB1 and GB2 subunits
Externí odkaz:
https://doaj.org/article/6104369c0098470197d3f546a913242f
Autor:
Pascal Dominic Rem, Vita Sereikaite, Diego Fernández-Fernández, Sebastian Reinartz, Daniel Ulrich, Thorsten Fritzius, Luca Trovo, Salomé Roux, Ziyang Chen, Philippe Rondard, Jean-Philippe Pin, Jochen Schwenk, Bernd Fakler, Martin Gassmann, Tania Rinaldi Barkat, Kristian Strømgaard, Bernhard Bettler
Publikováno v:
eLife, Vol 12 (2023)
Amyloid-β precursor protein (APP) regulates neuronal activity through the release of secreted APP (sAPP) acting at cell surface receptors. APP and sAPP were reported to bind to the extracellular sushi domain 1 (SD1) of GABAB receptors (GBRs). A 17 a
Externí odkaz:
https://doaj.org/article/f48ea31c4d5245788aa36e87dccbb8c4
Autor:
Li-Pao Fang, Na Zhao, Laura C. Caudal, Hsin-Fang Chang, Renping Zhao, Ching-Hsin Lin, Nadine Hainz, Carola Meier, Bernhard Bettler, Wenhui Huang, Anja Scheller, Frank Kirchhoff, Xianshu Bai
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Early postnatal interruption of the bidirectional GABA/TNFSF12 signaling between parvalbumin-positive interneurons and oligodendrocyte precursor cells impairs correct prefrontal cortical network activity and social cognitive behavior later in life.
Externí odkaz:
https://doaj.org/article/2d0a09c506374f3cb705f43e9434264f
Autor:
Runan Sun, Taku Tsunekawa, Tomonori Hirose, Hiroshi Yaginuma, Keigo Taki, Akira Mizoguchi, Takashi Miyata, Tomoko Kobayashi, Mariko Sugiyama, Takeshi Onoue, Hiroshi Takagi, Daisuke Hagiwara, Yoshihiro Ito, Shintaro Iwama, Hidetaka Suga, Ryoichi Banno, Bernhard Bettler, Hiroshi Arima
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Previous studies suggest that signaling by the gamma-aminobutyric acid (GABA) type B receptor (GABABR) is involved in the regulation of binge eating, a disorder which might contribute to the development of obesity. Here, we show that intermi
Externí odkaz:
https://doaj.org/article/a6c163f2cf0942a3b0a4e66cf7b17b42
Autor:
Mahnaz Mansouri, Leopold Kremser, Thanh-Phuong Nguyen, Yu Kasugai, Laura Caberlotto, Martin Gassmann, Bettina Sarg, Herbert Lindner, Bernhard Bettler, Lucia Carboni, Francesco Ferraguti
Publikováno v:
Cells, Vol 12, Iss 9, p 1325 (2023)
The metabotropic glutamate receptor 1 (mGlu1) plays a pivotal role in synaptic transmission and neuronal plasticity. Despite the fact that several interacting proteins involved in the mGlu1 subcellular trafficking and intracellular transduction mecha
Externí odkaz:
https://doaj.org/article/1fc6d52602db4e149a31891afc01bb64
Autor:
Taku Tsunekawa, Ryoichi Banno, Hiroshi Yaginuma, Keigo Taki, Akira Mizoguchi, Mariko Sugiyama, Takeshi Onoue, Hiroshi Takagi, Daisuke Hagiwara, Yoshihiro Ito, Shintaro Iwama, Motomitsu Goto, Hidetaka Suga, Bernhard Bettler, Hiroshi Arima
Publikováno v:
iScience, Vol 20, Iss , Pp 337-347 (2019)
Summary: Binge eating could contribute to the development of obesity, and previous studies suggest that gamma-aminobutyric acid (GABA) type B receptor (GABABR) signaling is involved in the regulation of binge eating. Here, we show that time-restricte
Externí odkaz:
https://doaj.org/article/ad12e467e8364f3881cefdcde71a5c7c
Autor:
Noelia P. Di Giorgio, Marianne Bizzozzero-Hiriart, Pablo N. Surkin, Esteban Repetto, María M. Bonaventura, Florencia N. Tabares, Nadia S. Bourguignon, Ayelén Converti, Juan M. Riaño Gomez, Bernhard Bettler, Victoria Lux-Lantos
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 324:E314-E329
We developed a unique mouse lacking GABAB receptors specifically in Kiss1 cells to evaluate the impact on reproduction and metabolism. Knockout males showed a severe impact on glucose homeostasis, which worsened with aging. These results reinforce th
Autor:
Pradeep Bhandari, David Vandael, Diego Fernández-Fernández, Thorsten Fritzius, David Kleindienst, Cihan Önal, Jacqueline Montanaro, Martin Gassmann, Peter Jonas, Akos Kulik, Bernhard Bettler, Ryuichi Shigemoto, Peter Koppensteiner
Publikováno v:
eLife, Vol 10 (2021)
The synaptic connection from medial habenula (MHb) to interpeduncular nucleus (IPN) is critical for emotion-related behaviors and uniquely expresses R-type Ca2+ channels (Cav2.3) and auxiliary GABAB receptor (GBR) subunits, the K+-channel tetrameriza
Externí odkaz:
https://doaj.org/article/0a37b242705b4a829d776d1abe599f5f
Autor:
Margarita C. Dinamarca, Adi Raveh, Andy Schneider, Thorsten Fritzius, Simon Früh, Pascal D. Rem, Michal Stawarski, Txomin Lalanne, Rostislav Turecek, Myeongjeong Choo, Valérie Besseyrias, Wolfgang Bildl, Detlef Bentrop, Matthias Staufenbiel, Martin Gassmann, Bernd Fakler, Jochen Schwenk, Bernhard Bettler
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
The mechanisms that control the presynaptic abundance of GABAB receptors (GBRs) remains unclear. This study shows that sequence-related epitopes in APP, AJAP-1 and PIANP bind with nanomolar affinities to the N-terminal sushi-domain of presynaptic GBR
Externí odkaz:
https://doaj.org/article/1122aad37c3e4affaea79ae9d7612a6d
Autor:
Letizia Mariotti, Gabriele Losi, Annamaria Lia, Marcello Melone, Angela Chiavegato, Marta Gómez-Gonzalo, Michele Sessolo, Serena Bovetti, Angelo Forli, Micaela Zonta, Linda Maria Requie, Iacopo Marcon, Arianna Pugliese, Cécile Viollet, Bernhard Bettler, Tommaso Fellin, Fiorenzo Conti, Giorgio Carmignoto
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Interneurons in the neocortex have functional and morphological subtypes. Here, Mariotti and colleagues show that activation of parvalbumin-expressing interneurons evokes depressing calcium responses in astrocytes while somatostatin-expressing intern
Externí odkaz:
https://doaj.org/article/456179a2c5a54300b6477423f829937e