Intracellular hemin is a potent inhibitor of the voltage-gated potassium channel Kv10.1.

Autor: Sahoo, Nirakar, Yang, Kefan, Coburger, Ina, Bernert, Alisa, Swain, Sandip M., Gessner, Guido, Kappl, Reinhard, Kühl, Toni, Imhof, Diana, Hoshi, Toshinori, Schönherr, Roland, Heinemann, Stefan H.

Publikováno v: Scientific Reports; 8/27/2022, Vol. 12 Issue 1, p1-12, 12p

Impact of intracellular hemin on N-type inactivation of voltage-gated K ⁺ channels.

Autor: Coburger I; Department of Biophysics, Center for Molecular Biomedicine, Friedrich Schiller University Jena and Jena University Hospital, Hans-Knöll-Str. 2, D-07745, Jena, Germany., Yang K; Department of Biophysics, Center for Molecular Biomedicine, Friedrich Schiller University Jena and Jena University Hospital, Hans-Knöll-Str. 2, D-07745, Jena, Germany., Bernert A; Department of Biophysics, Center for Molecular Biomedicine, Friedrich Schiller University Jena and Jena University Hospital, Hans-Knöll-Str. 2, D-07745, Jena, Germany., Wiesel E; Department of Biophysics, Center for Molecular Biomedicine, Friedrich Schiller University Jena and Jena University Hospital, Hans-Knöll-Str. 2, D-07745, Jena, Germany., Sahoo N; Department of Biophysics, Center for Molecular Biomedicine, Friedrich Schiller University Jena and Jena University Hospital, Hans-Knöll-Str. 2, D-07745, Jena, Germany.; Department of Biology, The University of Texas Rio Grande Valley, 1201 West University Drive, Edinburg, TX, 78539, USA., Swain SM; Department of Biophysics, Center for Molecular Biomedicine, Friedrich Schiller University Jena and Jena University Hospital, Hans-Knöll-Str. 2, D-07745, Jena, Germany.; Department of Medicine, Duke University and Durham VA Medical Centers, Durham, NC, 27710, USA., Hoshi T; Department of Physiology, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA, 19104-6085, USA., Schönherr R; Department of Biophysics, Center for Molecular Biomedicine, Friedrich Schiller University Jena and Jena University Hospital, Hans-Knöll-Str. 2, D-07745, Jena, Germany., Heinemann SH; Department of Biophysics, Center for Molecular Biomedicine, Friedrich Schiller University Jena and Jena University Hospital, Hans-Knöll-Str. 2, D-07745, Jena, Germany. Stefan.H.Heinemann@uni-jena.de.

Publikováno v: Pflugers Archiv : European journal of physiology [Pflugers Arch] 2020 May; Vol. 472 (5), pp. 551-560. Date of Electronic Publication: 2020 May 10.