Integrating Phenotypic Search and Phosphoproteomic Profiling of Active Kinases for Optimization of Drug Mixtures for RCC Treatment.

Autor: van Beijnum JR; Angiogenesis Laboratory, Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, De Boelelaan 1117, 1081HV, 1182 DB Amsterdam, The Netherlands., Weiss A; Molecular Pharmacology Group, School of Pharmaceutical Sciences, University of Geneva, 1211 Geneva, Switzerland.; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, 1211 Geneva, Switzerland., Berndsen RH; Angiogenesis Laboratory, Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, De Boelelaan 1117, 1081HV, 1182 DB Amsterdam, The Netherlands.; Molecular Pharmacology Group, School of Pharmaceutical Sciences, University of Geneva, 1211 Geneva, Switzerland., Wong TJ; Angiogenesis Laboratory, Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, De Boelelaan 1117, 1081HV, 1182 DB Amsterdam, The Netherlands., Reckman LC; Angiogenesis Laboratory, Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, De Boelelaan 1117, 1081HV, 1182 DB Amsterdam, The Netherlands., Piersma SR; Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, De Boelelaan 1117, 1081HV, 1182 DB Amsterdam, The Netherlands.; OncoProteomics Laboratory, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, 1081 HV Amsterdam, The Netherlands., Zoetemelk M; Molecular Pharmacology Group, School of Pharmaceutical Sciences, University of Geneva, 1211 Geneva, Switzerland.; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, 1211 Geneva, Switzerland., de Haas R; Angiogenesis Laboratory, Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, De Boelelaan 1117, 1081HV, 1182 DB Amsterdam, The Netherlands.; Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, De Boelelaan 1117, 1081HV, 1182 DB Amsterdam, The Netherlands.; OncoProteomics Laboratory, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, 1081 HV Amsterdam, The Netherlands., Dormond O; Department of Visceral surgery, Lausanne University Hospital and University of Lausanne, 1015 Lausanne, Switzerland., Bex A; Royal Free London NHS Foundation Trust, Renal Cancer Centre, University College London, Division of Surgical and Interventional Science, London NW3 2QG, UK.; Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands., Henneman AA; Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, De Boelelaan 1117, 1081HV, 1182 DB Amsterdam, The Netherlands.; OncoProteomics Laboratory, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, 1081 HV Amsterdam, The Netherlands., Jimenez CR; Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, De Boelelaan 1117, 1081HV, 1182 DB Amsterdam, The Netherlands.; OncoProteomics Laboratory, Amsterdam UMC, Vrije Universiteit Amsterdam, Cancer Center Amsterdam, 1081 HV Amsterdam, The Netherlands., Griffioen AW; Angiogenesis Laboratory, Department of Medical Oncology, Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, De Boelelaan 1117, 1081HV, 1182 DB Amsterdam, The Netherlands., Nowak-Sliwinska P; Molecular Pharmacology Group, School of Pharmaceutical Sciences, University of Geneva, 1211 Geneva, Switzerland.; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, 1211 Geneva, Switzerland.; Translational Research Centre in Oncohaematology, 1211 Geneva, Switzerland.

Publikováno v: Cancers [Cancers (Basel)] 2020 Sep 21; Vol. 12 (9). Date of Electronic Publication: 2020 Sep 21.

Colorectal Cancer Growth Retardation through Induction of Apoptosis, Using an Optimized Synergistic Cocktail of Axitinib, Erlotinib, and Dasatinib.

Autor: Berndsen RH; Molecular Pharmacology Group, Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Rue Michel-Servet 1, 1211 Geneva, Switzerland.; Angiogenesis Laboratory, Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC-Location VUmc, VU University Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands., Swier N; Angiogenesis Laboratory, Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC-Location VUmc, VU University Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands., van Beijnum JR; Angiogenesis Laboratory, Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC-Location VUmc, VU University Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands., Nowak-Sliwinska P; Molecular Pharmacology Group, Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Rue Michel-Servet 1, 1211 Geneva, Switzerland.; Translational Research Center in Oncohaematology, Rue Michel-Servet 1, 1211 Geneva, Switzerland.

Publikováno v: Cancers [Cancers (Basel)] 2019 Nov 27; Vol. 11 (12). Date of Electronic Publication: 2019 Nov 27.

Epigenetic approach for angiostatic therapy: promising combinations for cancer treatment.

Autor: Berndsen RH; Department of Medical Oncology, VU University Medical Center, 1007, MB, Amsterdam, The Netherlands., Abdul UK; Department of Medical Oncology, VU University Medical Center, 1007, MB, Amsterdam, The Netherlands., Weiss A; School of Pharmaceutical Sciences, University of Geneva, Rue Michel-Servet 1, 1211, Geneva, Switzerland., Zoetemelk M; School of Pharmaceutical Sciences, University of Geneva, Rue Michel-Servet 1, 1211, Geneva, Switzerland., Te Winkel MT; Department of Medical Oncology, VU University Medical Center, 1007, MB, Amsterdam, The Netherlands., Dyson PJ; Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology, 1015, Lausanne, Switzerland., Griffioen AW; Department of Medical Oncology, VU University Medical Center, 1007, MB, Amsterdam, The Netherlands., Nowak-Sliwinska P; School of Pharmaceutical Sciences, University of Geneva, Rue Michel-Servet 1, 1211, Geneva, Switzerland. Patrycja.Nowak-Sliwinska@unige.ch.

Publikováno v: Angiogenesis [Angiogenesis] 2017 May; Vol. 20 (2), pp. 245-267. Date of Electronic Publication: 2017 Apr 04.

A streamlined search technology for identification of synergistic drug combinations.

Autor: Weiss A; Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.; Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands., Berndsen RH; Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland., Ding X; Med-X Research Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China., Ho CM; Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, USA., Dyson PJ; Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland., van den Bergh H; Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland., Griffioen AW; Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands., Nowak-Sliwinska P; Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland.; Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands.

Publikováno v: Scientific reports [Sci Rep] 2015 Sep 29; Vol. 5, pp. 14508. Date of Electronic Publication: 2015 Sep 29.

Angiostatic treatment prior to chemo- or photodynamic therapy improves anti-tumor efficacy.

Autor: Weiss A; 1] Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland [2] Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center Amsterdam, The Netherlands., Bonvin D; Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland., Berndsen RH; 1] Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland [2] Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center Amsterdam, The Netherlands., Scherrer E; Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland., Wong TJ; Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center Amsterdam, The Netherlands., Dyson PJ; Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland., Griffioen AW; Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center Amsterdam, The Netherlands., Nowak-Sliwinska P; 1] Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology (EPFL), Lausanne, Switzerland [2] Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center Amsterdam, The Netherlands.

Publikováno v: Scientific reports [Sci Rep] 2015 Mar 11; Vol. 5, pp. 8990. Date of Electronic Publication: 2015 Mar 11.