Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Bernd-Ulrich von Specht"'
Publikováno v:
Vaccine. 28:4119-4122
The recombinant outer membrane protein OprF/I has been demonstrated in previous studies to protect against Pseudomonas aeruginosa infection through a mechanism of enhanced antibody-mediated opsonophagocytosis. Recent evidence indicates that P. aerugi
Autor:
Ulrich Baumann, Melanie Felies, Bernd Ulrich von Specht, Joachim Freihorst, Heinz Arnold, Meike Sörensen, J. Engelbert Gessner, Britta Gewecke, Dirk Bumann
Publikováno v:
Infection and Immunity. 72:6546-6553
We constructed an oral live vaccine based on the attenuatedaroAmutantSalmonella entericaserovar Typhimurium strain SL3261 expressing outer membrane proteins F and I (OprF-OprI) fromPseudomonas aeruginosaand investigated it in a mouse model. Strains w
Autor:
Heinz P Hahn, Bernd Ulrich von Specht
Publikováno v:
FEMS Immunology & Medical Microbiology. 37:87-98
Live attenuated Salmonella strains have been extensively explored as oral delivery systems for recombinant vaccine antigens and effector proteins with immunoadjuvant and immunomodulatory potential. The feasibility of this approach was demonstrated in
Publikováno v:
FEMS Immunology & Medical Microbiology. 37:161-166
In a recent clinical trial we evaluated the safety and immunogenicity of a recombinant OprF-OprI vaccine consisting of the mature outer membrane protein I (OprI) and amino acids 190-342 of OprF of Pseudomonas aeruginosa in burn patients and compared
Autor:
Claudia Heilmann, Georg Lutter, Patrick von Samson, Friedhelm Beyersdorf, Tim Attmann, Kerstin Schlegel, Bernd Ulrich von Specht
Publikováno v:
European Journal of Cardio-Thoracic Surgery. 22:957-964
Objective: Treatment of coronary disease by growth factors has become an increasingly used strategy for otherwise untreatable patients and is subject to a number of clinical studies. The aim is to stimulate the development of a sufficient collateral
Publikováno v:
Protein Expression and Purification. 25:437-447
Previously, we constructed human interleukin-6 (hIL-6)-secreting Escherichia coli and Salmonella typhimurium strains by fusion of the hIL-6 cDNA to the HlyA(s) secretional signal, utilizing the hemolysin export apparatus for extracellular delivery of
Autor:
J Barten Legutki, Brian M. Price, John Staczek, Darrell R. Galloway, Bernd Ulrich von Specht, Linda B. Gilleland, Harry E. Gilleland
Publikováno v:
FEMS Immunology & Medical Microbiology. 33:89-99
The outer membrane protein F gene (oprF) of Pseudomonas aeruginosa was recently shown by us to protect mice from P. aeruginosa chronic pulmonary infection when used as a DNA vaccine administered by three biolistic (gene gun) intradermal inoculations
Publikováno v:
FEMS Microbiology Letters. 201:277-283
To identify the outer membrane protein component of the Caulobacter crescentus CB2 surface-layer export machinery we used the Serratia marcescens LipD protein to find homologs in the CB2 genome. From two homologous sequences found, one encodes a puta
Publikováno v:
FEMS Immunology & Medical Microbiology. 27:333-340
Previously, we reported a plasmid-bearing Salmonella typhimurium strain capable of secreting human interleukin-6 (hIL-6) when genetically fused to the Escherichia coli hemolysin transport signal (HlyA(S)). Stationary phase culture supernatants of thi
Autor:
Rainer Amberg, Eduard H. Farthmann, U. Schöffel, Bernd-Ulrich von Specht, Wolfgang Sendt, Asem Hassan
Publikováno v:
The European Journal of Surgery. 165:1024-1030
To test the hypothesis that different surgical procedures may lead to different degrees of activation of the human peritoneal response.Clinical laboratory study.University Hospital, Germany.Peritoneal specimens taken from the incision or parietal res