Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Bernd-Michael Löffler"'
Autor:
Shintu Jude, Augustine Amalraj, Ajaikumar B. Kunnumakkara, Chandradhara Divya, Bernd-Michael Löffler, Sreeraj Gopi
Publikováno v:
Molecules, Vol 23, Iss 10, p 2415 (2018)
Specific and sensitive ultra-high performance liquid chromatography-quadrupole time of flight-mass spectroscopy (UPLC-QTOF-MS) methods have been developed for the determination of curcuminoids and curcumin metabolites in human blood plasma. The UPLC-
Externí odkaz:
https://doaj.org/article/30b29441c6db4dceb16024affabad4ac
Publikováno v:
The Chemistry and Bioactive Components of Turmeric ISBN: 9781788015554
Curcuminoids are one of the most widely studied phytochemical moieties, owing to their potential therapeutic efficiency as well as the limitations observed in their bioavailability. So far, curcumin is the derivative that is at the center of research
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a268d03de32845d6473b25001152f626
https://doi.org/10.1039/9781788015936-00104
https://doi.org/10.1039/9781788015936-00104
Autor:
Chandradhara Divya, Ajaikumar B. Kunnumakkara, Augustine Amalraj, Sreeraj Gopi, Bernd-Michael Löffler, Shintu Jude
Publikováno v:
Molecules, Vol 23, Iss 10, p 2415 (2018)
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules
Volume 23
Issue 10
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules
Volume 23
Issue 10
Specific and sensitive ultra-high performance liquid chromatography-quadrupole time of flight-mass spectroscopy (UPLC-QTOF-MS) methods have been developed for the determination of curcuminoids and curcumin metabolites in human blood plasma. The UPLC-
Autor:
Bernd Kuhn, Hans Peter Wessel, Jens-Uwe Peters, Patrizio Mattei, Robert Narquizian, Pierre C. Wyss, Luca Gobbi, Daniel Hunziker, Thomas Lübbers, Bernd Michael Löffler, Markus Bohringer, Yves Ruff, Michael Hennig
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2966-2970
In a search for novel DPP-IV inhibitors, 2-aminobenzo[a]quinolizines were identified as submicromolar HTS hits. Due to the difficult synthetic access to this compound class, 1,3-disubstituted 4-aminopiperidines were used as model compounds for optimi
Autor:
Bernd-Michael Löffler, Johannes Aebi, Lucienne Juillerat-Jeanneret, Eric A. Kitas, Henrietta Dehmlow, Denise Blum-Kaelin, Yann Berger
Publikováno v:
Journal of Medicinal Chemistry. 48:483-498
Endothelin-1 (ET-1) is mitogenic and/or antiapoptotic in human cancers, and antagonists to ET-1 receptors are under evaluation for cancer treatment. Inhibition of ET-1 activation by the endothelin-converting enzymes 1(a)(-)(d) (ECE-1(a)(-)(d); EC 3.4
Publikováno v:
Structure. 11(8):947-959
Inhibition of dipeptidyl peptidase IV (DPP-IV), the main glucagon-like peptide 1 (GLP1)-degrading enzyme, has been proposed for the treatment of type II diabetes. We expressed and purified the ectodomain of human DPP-IV in Pichia pastoris and determi
Publikováno v:
Current Eye Research. 24:6-11
The important role of ET-1 in vasoconstriction has been shown for the vasoregulation in the retina, choroid and optic nerve. ET-1 induced vaso-constriction, however, can be treated effectively at the level of endothelin-1 converting enzyme (ECE-1) by
Autor:
Nicolas von Ahsen, Anna-Leena Sirén, Piotr Lewczuk, Hannelore Ehrenreich, Martin Hasselblatt, Bernd-Michael Löffler, Heike Kamrowski-Kruck
Publikováno v:
Glia. 34:18-26
Astrocytes are known to possess an effective endothelin (ET) eliminatory system which involves astrocytic ETA and ETB receptors and may become particularly relevant under pathophysiological conditions. The present study has therefore been designed to
Autor:
Dominik N. Müller, Joon-Keun Park, Bernd-Michael Löffler, Hermann Haller, Volker Breu, Ralf Dechend, Elke Genersch, Wolfgang Schneider, Friedrich C. Luft, Detlev Ganten, Folke Schmidt, Eero Mervaala
Publikováno v:
Scopus-Elsevier
Abstract —Reports on the effectiveness of endothelin receptor blockers in angiotensin (Ang) II–induced end-organ damage are conflicting, and the mechanisms involved are uncertain. We tested the hypothesis that endothelin (ET) A/B receptor blockad
Autor:
Wolfgang Brück, Jan Oldenburg, Anna-Leena Sirén, Hannelore Ehrenreich, Lothar Schilling, Stefan Gall, Jochen Herms, Bernd-Michael Löffler, Martin Hasselblatt, Heike Kamrowski-Kruck, C. Dembowski
Publikováno v:
Neuroscience. 91:1067-1075
Endothelins, due to their potent vasoactivity and mitogenicity, appear to play an important role in the brain, where all components of the endothelin system, peptides, receptors and converting enzyme, are expressed. To further elucidate the role of t