Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Bernd Schwenzer"'
Autor:
Anika Kaufmann, Silke Hampel, Christiane Rieger, David Kunhardt, Darja Schendel, Susanne Füssel, Bernd Schwenzer, Kati Erdmann
Publikováno v:
Journal of Nanobiotechnology, Vol 15, Iss 1, Pp 1-15 (2017)
Abstract Background In addition to conventional chemotherapeutics, nucleic acid-based therapeutics like antisense oligodeoxynucleotides (AS-ODN) represent a novel approach for the treatment of bladder cancer (BCa). An efficient delivery of AS-ODN to
Externí odkaz:
https://doaj.org/article/abd1a16f90734ac8967c3632a5b55d23
Autor:
Julia V Wölfle, Jörg Fiedler, Lutz Dürselen, Judith Reichert, Dieter Scharnweber, Anne Förster, Bernd Schwenzer, Heiko Reichel, Anita Ignatius, Rolf E Brenner
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86151 (2014)
The aim of the present study was to test the biocompatibility and functionality of orthopaedic bone implants with immobilized oligonucleotides serving as anchor stands for rhBMP-2 and rhVEGF-A conjugated with complementary oligonucleotides in an oste
Externí odkaz:
https://doaj.org/article/78cbdc2a471146c6aa2380e214105f73
Autor:
Cornelia Wolf-Brandstetter, Bernd Schwenzer, Henning Schliephake, Dieter Scharnweber, Vanessa Hänchen, Nelia Aeckerle
Publikováno v:
ACS Applied Materials & Interfaces. 8:3755-3764
Immobilization of bioactive molecules (BAMs) on a nanometer scale is of great interest for functionalization of implant and scaffold surfaces in current biomaterials research. A system for immobilization of one or more compounds is described, which i
Autor:
Bernd Schwenzer, N Aeckerle, Judith Reichert, Dieter Scharnweber, Henning Schliephake, Anne Förster, J Rublack
Publikováno v:
European Cells & Materials, Vol 30, Pp 28-40 (2015)
The aim of the present study was to test the hypothesis that immobilisation of bone morphogenic proteins on the surface of titanium implants through nano-anchored oligonucleotides can enhance peri-implant bone formation. Non-coding 60-mer DNA oligonu
Autor:
Bernd Schwenzer, Anne Förster, Henning Schliephake, Judith Reichert, Dieter Scharnweber, Jennifer Rublack
Publikováno v:
Journal of Clinical Periodontology. 42:302-310
Aims To test the immobilization of vascular endothelial growth factor (VEGF165) on the surface of titanium implants using DNA oligonucleotide (ODN) anchor strands for the ability to enhance periimplant bone formation. Materials and Methods DNA oligon
Autor:
Darja Schendel, Stefan Propping, Anika Kaufmann, Doreen Huebner, Christiane Rieger, Bernd Schwenzer, Kati Erdmann, Susanne Fuessel, Silke Hampel, Manfred P. Wirth, David Kunhardt
Publikováno v:
International Journal of Pharmaceutics. 479:357-363
In order to increase the effectiveness of therapeutics for bladder carcinoma (BCa) treatment, alternative strategies for intravesical applications are needed. The use of carbon nanotubes (CNTs) as basis for a multifunctional drug transporter is a pro
Publikováno v:
J. Mater. Chem. B. 2:7000-7008
The use of DNA-based therapeutics requires efficient delivery systems to transport the DNA to their place of action within the cell. To accomplish this, we investigated multiwalled carbon nanotubes (pristine MWCNT, p-MWCNT) functionalized with hydrox
Autor:
Corinna Mauth, Tina Schaefer, Anne Gaebler, Dieter Scharnweber, Bernd Schwenzer, Kathleen Fischer
Publikováno v:
Acta Biomaterialia. 9:4899-4905
Herein we describe the use of peptide linkers to establish a nucleic acid-based immobilization system based on biphasic calcium phosphates (BCP), with which different molecules can be immobilized at the same time in defined ratios. It consists of sin
Autor:
Henning Schliephake, N Strecker, Bernd Schwenzer, Anne Förster, Judith Reichert, Dieter Scharnweber
Publikováno v:
European Cells & Materials, Vol 23, Pp 161-169 (2012)
The aim of the present study was to test the hypothesis that sandblasted and acid etched titanium surfaces can be functionalised with vascular endothelial growth factor (VEGF) using oligonucleotides for anchorage and slow release. rhVEGF165 molecules
Autor:
Markus Böhl, Bernd Schwenzer
Publikováno v:
Chemical Biology & Drug Design. 69:212-215
We compared an antisense-oligodeoxynucleotide and four DNAzymes directed to the prothrombin mRNA for their efficiency to reduce prothrombin transcript level in HepG2 cells. The DNAzymes have different binding arm symmetry and cleavage sites, but are