Zobrazeno 1 - 10
of 247
pro vyhledávání: '"Bernd Schmeck"'
Autor:
Daniela Zöller, Christian Haverkamp, Adeline Makoudjou, Ghislain Sofack, Saskia Kiefer, Denis Gebele, Michelle Pfaffenlehner, Martin Boeker, Harald Binder, Kapil Karki, Christian Seidemann, Bernd Schmeck, Timm Greulich, Harald Renz, Stefanie Schild, Susanne A. Seuchter, Dativa Tibyampansha, Roland Buhl, Gernot Rohde, Franziska C. Trudzinski, Robert Bals, Sabina Janciauskiene, Daiana Stolz, Sebastian Fähndrich
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Background Chronic obstructive pulmonary disease (COPD) is an inflammatory multisystemic disease caused by environmental exposures and/or genetic factors. Inherited alpha-1-antitrypsin deficiency (AATD) is one of the best recognized genetic
Externí odkaz:
https://doaj.org/article/3f847567425d47e5befc939a121eab8a
Autor:
Marie Burt, Georgia Angelidou, Christopher Nils Mais, Christian Preußer, Timo Glatter, Thomas Heimerl, Rüdiger Groß, Javier Serrania, Gowtham Boosarpu, Elke Pogge von Strandmann, Janis A. Müller, Gert Bange, Anke Becker, Mareike Lehmann, Danny Jonigk, Lavinia Neubert, Hinrich Freitag, Nicole Paczia, Bernd Schmeck, Anna Lena Jung
Publikováno v:
Journal of Extracellular Vesicles, Vol 13, Iss 5, Pp n/a-n/a (2024)
Abstract The continuous emergence of multidrug‐resistant bacterial pathogens poses a major global healthcare challenge, with Klebsiella pneumoniae being a prominent threat. We conducted a comprehensive study on K. pneumoniae’s antibiotic resistan
Externí odkaz:
https://doaj.org/article/d578823b51904a85bb20616a75988ddc
Autor:
Wilhelm Bertrams, Jochen Wilhelm, Pia-Marie Veeger, Carolina Hanko, Kristina auf dem Brinke, Björn Klabunde, Hendrik Pott, Barbara Weckler, Timm Greulich, Claus F. Vogelmeier, Bernd Schmeck
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
IntroductionPatients suffering from chronic obstructive pulmonary disease (COPD) are prone to acute exacerbations (AECOPD) or community acquired pneumonia (CAP), both posing severe risk of morbidity and mortality. There is no available biomarker that
Externí odkaz:
https://doaj.org/article/f827b8a31c5541f8ad98654025563d86
Autor:
Amir Pandi, David Adam, Amir Zare, Van Tuan Trinh, Stefan L. Schaefer, Marie Burt, Björn Klabunde, Elizaveta Bobkova, Manish Kushwaha, Yeganeh Foroughijabbari, Peter Braun, Christoph Spahn, Christian Preußer, Elke Pogge von Strandmann, Helge B. Bode, Heiner von Buttlar, Wilhelm Bertrams, Anna Lena Jung, Frank Abendroth, Bernd Schmeck, Gerhard Hummer, Olalla Vázquez, Tobias J. Erb
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Bioactive peptides are key molecules in health and medicine. Deep learning holds a big promise for the discovery and design of bioactive peptides. Yet, suitable experimental approaches are required to validate candidates in high throughput a
Externí odkaz:
https://doaj.org/article/adbbacf7db9c45aca2f0981cf0f79344
Autor:
Björn Klabunde, André Wesener, Wilhelm Bertrams, Isabell Beinborn, Nicole Paczia, Kristin Surmann, Sascha Blankenburg, Jochen Wilhelm, Javier Serrania, Kèvin Knoops, Eslam M. Elsayed, Katrin Laakmann, Anna Lena Jung, Andreas Kirschbaum, Sven Hammerschmidt, Belal Alshaar, Nicolas Gisch, Mobarak Abu Mraheil, Anke Becker, Uwe Völker, Evelyn Vollmeister, Birke J. Benedikter, Bernd Schmeck
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Lower respiratory tract infections caused by Streptococcus pneumoniae (Spn) are a leading cause of death globally. Here we investigate the bronchial epithelial cellular response to Spn infection on a transcriptomic, proteomic and metabolic l
Externí odkaz:
https://doaj.org/article/f53e17d7ffee4a8b866fd16db80c5bb8
Autor:
Björn Klabunde, André Wesener, Wilhelm Bertrams, Stephan Ringshandl, Luke D. Halder, Evelyn Vollmeister, Bernd Schmeck, Birke J. Benedikter
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-10 (2023)
Abstract Background Lung infections caused by Streptococcus pneumonia are a global leading cause of death. The reactive oxygen species H2O2 is one of the virulence factors of Streptococcus pneumoniae. The Golgi apparatus is essential for the inflamma
Externí odkaz:
https://doaj.org/article/55b9010d63cd4bee8e868367fb2bf524
Autor:
Katrin Laakmann, Jorina Mona Eckersberg, Moritz Hapke, Marie Wiegand, Jeff Bierwagen, Isabell Beinborn, Christian Preußer, Elke Pogge von Strandmann, Thomas Heimerl, Bernd Schmeck, Anna Lena Jung
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background Sepsis is one of the leading causes of death worldwide and characterized by blood stream infections associated with a dysregulated host response and endothelial cell (EC) dysfunction. Ribonuclease 1 (RNase1) acts as a protective f
Externí odkaz:
https://doaj.org/article/7c0269688b8b458fb4d7267fe2e39b81
Autor:
Jeff Bierwagen, Marie Wiegand, Katrin Laakmann, Olga Danov, Hannah Limburg, Stefanie Muriel Herbel, Thomas Heimerl, Jens Dorna, Danny Jonigk, Christian Preußer, Wilhelm Bertrams, Armin Braun, Katherina Sewald, Leon N. Schulte, Stefan Bauer, Elke Pogge von Strandmann, Eva Böttcher-Friebertshäuser, Bernd Schmeck, Anna Lena Jung
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Gram-negative bacteria naturally secrete nano-sized outer membrane vesicles (OMVs), which are important mediators of communication and pathogenesis. OMV uptake by host cells activates TLR signalling via transported PAMPs. As important reside
Externí odkaz:
https://doaj.org/article/5ab97f46113346758e29ef1c0e67adfd
Autor:
Stefanie M. Herbel, Lambert Moyon, Marvin Christ, Eslam M. Elsayed, Brian E. Caffrey, Silke Malmsheimer, Iwan Grin, Kerstin Hoffmann, Kristin Surmann, Sascha Blankenburg, Anna Lena Jung, Christina E. Herkt, Marco Borsò, Beyza Bozdag, Axel Imhof, Anke Becker, Samuel Wagner, Gert Bange, Uwe Völker, Wilhelm Bertrams, Annalisa Marsico, Bernd Schmeck
Publikováno v:
Virulence, Vol 13, Iss 1, Pp 2042-2058 (2022)
Legionella pneumophila (L.p.) is a bacterial pathogen which is a common causative agent of pneumonia. In humans, it infects alveolar macrophages and transfers hundreds of virulence factors that interfere with cellular signalling pathways and the tran
Externí odkaz:
https://doaj.org/article/3cfbe5db3b0f4145a005db5fed54388b
Autor:
Anna Lena Jung, Maria Han, Kathrin Griss, Wilhelm Bertrams, Christoph Nell, Timm Greulich, Andreas Klemmer, Hendrik Pott, Dominik Heider, Claus F. Vogelmeier, Stefan Hippenstiel, Norbert Suttorp, Bernd Schmeck
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
IntroductionCommunity-acquired pneumonia (CAP) and acute exacerbations of chronic obstructive pulmonary disease (AECOPD) result in high morbidity, mortality, and socio-economic burden. The usage of easily accessible biomarkers informing on disease en
Externí odkaz:
https://doaj.org/article/19100ed459f44882b71674f7d9a3346d