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Akademický článek

SwissPKcdw – A clinical data warehouse for the optimization of pediatric dosing regimens

Autor: Roland Goers, Diana Coman Schmid, Vera F. Jäggi, Paolo Paioni, Michal J. Okoniewski, Althea Parker, Beat Bangerter, Sofia Georgakopoulou, Thierry Sengstag, Julia Bielicki, Romy Tilen, Swen Vermeul, Stefanie D. Krämer, Christoph Berger, Bernd Rinn, Henriette E. Meyer zu Schwabedissen

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 12, Pp 1578-1587 (2021)

Abstract Clinical trials have been performed mainly in adults and accordingly the necessary information is lacking for pediatric patients, especially regarding dosage recommendation for approved drugs. This gap in information could be filled with res

Externí odkaz: https://doaj.org/article/1bfbcff86d324ff3b15781ea26768d4d

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Akademický článek

Gentamicin Population Pharmacokinetics in Pediatric Patients—A Prospective Study with Data Analysis Using the saemix Package in R

Autor: Paolo Paioni, Vera F. Jäggi, Romy Tilen, Michelle Seiler, Philipp Baumann, Dominic S. Bräm, Carole Jetzer, Robin T. U. Haid, Aljoscha N. Goetschi, Roland Goers, Daniel Müller, Diana Coman Schmid, Henriette E. Meyer zu Schwabedissen, Bernd Rinn, Christoph Berger, Stefanie D. Krämer

Publikováno v: Pharmaceutics, Vol 13, Iss 10, p 1596 (2021)

The aminoglycoside gentamicin is used for the empirical treatment of pediatric infections. It has a narrow therapeutic window. In this prospective study at University Children’s Hospital Zurich, Switzerland, we aimed to characterize the pharmacokin

Externí odkaz: https://doaj.org/article/acfd0ccad93d4489bfdb8b56e9eb95a5

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SwissPKcdw - A clinical data warehouse for the optimization of pediatric dosing regimens

Autor: Romy Tilen, Bernd Rinn, Michal J. Okoniewski, Stefanie D. Krämer, Diana Coman Schmid, Henriette E. Meyer zu Schwabedissen, Swen Vermeul, Sofia Georgakopoulou, Christoph Berger, Roland Goers, Beat Bangerter, Julia Bielicki, Thierry Sengstag, Vera F. Jäggi, Paolo Paioni, Althea Parker

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 12, Pp 1578-1587 (2021)

Clinical trials have been performed mainly in adults and accordingly the necessary information is lacking for pediatric patients, especially regarding dosage recommendation for approved drugs. This gap in information could be filled with results from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::921eee4f9c281ca95942a4a34c61e292
https://openaccess.sgul.ac.uk/id/eprint/113864/1/psp4.12723.pdf

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SwissPK

Autor: Roland, Goers, Diana, Coman Schmid, Vera F, Jäggi, Paolo, Paioni, Michal J, Okoniewski, Althea, Parker, Beat, Bangerter, Sofia, Georgakopoulou, Thierry, Sengstag, Julia, Bielicki, Romy, Tilen, Swen, Vermeul, Stefanie D, Krämer, Christoph, Berger, Bernd, Rinn, Henriette E, Meyer Zu Schwabedissen

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5643622c01c1d605ab8239a3fdf3079a
https://pubmed.ncbi.nlm.nih.gov/34729953

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SPHN - The BioMedIT Network: A Secure IT Platform for Research with Sensitive Human Data

Autor: Diana, Coman Schmid, Katrin, Crameri, Sabine, Oesterle, Bernd, Rinn, Thierry, Sengstag, Heinz, Stockinger, Thomas, Wüst

Publikováno v: Studies in health technology and informatics. 270

The BioMedIT project is funded by the Swiss government as an integral part of the Swiss Personalized Health Network (SPHN), aiming to provide researchers with access to a secure, powerful and versatile IT infrastructure for doing data-driven research

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a2596e6b23b6c789f1461f17a0d322ef
https://pubmed.ncbi.nlm.nih.gov/32570566

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Computer vision profiling of neurite outgrowth dynamics reveals spatiotemporal modularity of Rho GTPase signaling

Autor: Fethallah Benmansour, Bernd Rinn, Germán González, Kevin Smith, Pascal Fua, Ludovico Fusco, François Fleuret, Riwal Lefort, Caterina Barillari, Olivier Pertz

Publikováno v: The Journal of Cell Biology
The Journal of cell biology
Fusco, Ludovico; Lefort, Riwal; Smith, Kevin; Benmansour, Fethallah; Gonzalez, German; Barillari, Caterina; Rinn, Bernd; Fleuret, Francois; Fua, Pascal; Pertz, Olivier (2016). Computer vision profiling of neurite outgrowth dynamics reveals spatiotemporal modularity of Rho GTPase signaling. Journal of cell biology, 212(1), pp. 91-111. Rockefeller Institute Press 10.1083/jcb.201506018

NeuriteTracker is a computer vision approach used to analyze neuronal morphodynamics and to examine spatiotemporal Rho GTPase signaling networks regulating neurite outgrowth.
Rho guanosine triphosphatases (GTPases) control the cytoskeletal dynam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7efd7b40e9819069e3b64a1d42932d4a
http://europepmc.org/articles/PMC4700477

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NGS-pipe: a flexible, easily extendable, and highly configurable framework for NGS analysis

Publikováno v: Bioinformatics, 34 (1)
Bioinformatics

Motivation Next-generation sequencing is now an established method in genomics, and massive amounts of sequencing data are being generated on a regular basis. Analysis of the sequencing data is typically performed by lab-specific in-house solutions,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204a8126a1f41b186b3a8f73c8512e85

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iPortal: the swiss grid proteomics portal: Requirements and new features based on experience and usability considerations

Autor: Lars Malmström, Witold Wolski, Bernd Rinn, Chandrasekhar Ramakrishnan, Adam Srebniak, Franz-Josef Elmer, Lorenz C. Blum, Peter Z. Kunszt, Béla Hullár, Emanuel Schmid, Andreas Quandt

Publikováno v: Concurrency and Computation: Practice and Experience. 27:433-445

Summary Development of workflow and data management systems are challenging because of the need to provide a service for users with varying degrees of expertise from novices to experts with more knowledge than the developers. We have received feedbac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d43c526c4d6c04da35f7de73735912b
https://doi.org/10.1002/cpe.3294

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FAIRDOMHub: a repository and collaboration environment for sharing systems biology research

Autor: Katherine, Wolstencroft, Olga, Krebs, Jacky L, Snoep, Natalie J, Stanford, Finn, Bacall, Martin, Golebiewski, Rostyk, Kuzyakiv, Quyen, Nguyen, Stuart, Owen, Stian, Soiland-Reyes, Jakub, Straszewski, David D, van Niekerk, Alan R, Williams, Lars, Malmström, Bernd, Rinn, Wolfgang, Müller, Carole, Goble

Publikováno v: Nucleic Acids Research

The FAIRDOMHub is a repository for publishing FAIR (Findable, Accessible, Interoperable and Reusable) Data, Operating procedures and Models (https://fairdomhub.org/) for the Systems Biology community. It is a web-accessible repository for storing and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aeebdf8b44ec109c1b5d9ace97519f4f
https://pubmed.ncbi.nlm.nih.gov/27899646

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OpenBIS ELN-LIMS: An open-source database for academic laboratories

Autor: Diana S. M. Ottoz, Chandrasekhar Ramakrishnan, Bernd Rinn, Juan Mariano Fuentes-Serna, Fabian Rudolf, Caterina Barillari

Publikováno v: Bioinformatics, 32 (4)
Bioinformatics

The open-source platform openBIS (open Biology Information System) offers an Electronic Laboratory Notebook and a Laboratory Information Management System (ELN-LIMS) solution suitable for the academic life science laboratories. openBIS ELN-LIMS allow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d338a78426e8f1564dc7a5c2dd5bbe37
https://hdl.handle.net/20.500.11850/109095

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