Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Bernd Potzsch"'
Autor:
Nasim Shahidi Hamedani, Felix Lucian Happich, Eva-Maria Klein, Heiko Rühl, Günter Mayer, Johannes Oldenburg, Jens Müller, Bernd Pötzsch
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Activated protein C (APC) is a serine protease with anticoagulant and cytoprotective activities which make it an attractive target for diagnostic and therapeutic applications. In this work, we present one-step activation of APC from a commer
Externí odkaz:
https://doaj.org/article/4baba1e3aa6644ab833ea7b0573e83b9
Autor:
Tobias Becher, Robert Schimanski, Jens Müller, Stefan Baumann, Selina Klenantz, Bernd Pötzsch, Dirk Lossnitzer
Publikováno v:
International Journal of Cardiology: Heart & Vasculature, Vol 42, Iss , Pp 101097- (2022)
Introduction: Activation of the plasmatic coagulation system is a major contributor to acute myocardial infarction (AMI). Markers of plasmatic coagulation and thrombin activation are correlated with clinical, laboratory and outcome parameters. In thi
Externí odkaz:
https://doaj.org/article/8e74f8ce16504986bcaaf67adfc75ba2
Autor:
Sara Reda, Elena Thiele Serra, Jens Müller, Nasim Shahidi Hamedani, Johannes Oldenburg, Bernd Pötzsch, Heiko Rühl
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Elevated D-dimer levels during anticoagulant therapy with vitamin K antagonists (VKA) are associated with an increased risk of thrombosis. It has been hypothesized that elevated D-dimer levels in patients receiving direct oral anticoagulants (DOACs)
Externí odkaz:
https://doaj.org/article/0ca25618809d4bdaab99d15b0945837a
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0271330 (2022)
Emicizumab mimics the hemostatic activity of activated factor VIII (FVIIIa) within the tenase complex. Despite functional similarities between FVIIIa and emicizumab, conventional laboratory methods designed for monitoring of FVIII activity are inappr
Externí odkaz:
https://doaj.org/article/27951d9540954b22bef2abe0cf16a06d
Autor:
Sara Reda, Heiko Rühl, Jana Witkowski, Jens Müller, Anna Pavlova, Johannes Oldenburg, Bernd Pötzsch
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Protein C (PC) activity tests are routinely performed in a thrombophilia workup to screen for PC deficiency. Currently used tests combine conversion of PC to activated PC (APC) by the snake venom Protac with subsequent APC detection through hydrolysi
Externí odkaz:
https://doaj.org/article/93cec0a03e7d45b7b14e348be6cbceaa
Autor:
Amit Sharma, Jens Müller, Karin Schuetze, Verena Rolfes, Rosi Bissinger, Nathalia Rosero, Ashar Ahmad, Bernardo S Franklin, Berndt Zur, Holger Fröhlich, Florian Lang, Johannes Oldenburg, Bernd Pötzsch, Ullrich Wüllner
Publikováno v:
Biology, Vol 10, Iss 8, p 716 (2021)
Parkinson’s disease (PD) is the second most common age-related neurodegenerative disease. Accumulating evidence demonstrates that alpha-synuclein (α-Syn), an apparently predominant neuronal protein, is a major contributor to PD pathology. As α-Sy
Externí odkaz:
https://doaj.org/article/b56abce92eac4b839ec6b176420b1718
Autor:
Max Julian Friedrich, Jan Schmolders, Yorck Rommelspacher, Andreas Strauss, Heiko Rühl, Günter Mayer, Johannes Oldenburg, Dieter Christian Wirtz, Jens Müller, Bernd Pötzsch
Publikováno v:
TH Open, Vol 02, Iss 04, Pp e350-e356 (2018)
In the nonbleeding patient, constant low-level activation of coagulation enables a quick procoagulant response upon an injury. Conversely, local activation of coagulation might influence the systemic activity level of coagulation. To characterize thi
Externí odkaz:
https://doaj.org/article/fe2615e0be98450aad294468f3fae810
Autor:
Jan Moritz Ponert, Svenja Schwarz, Reza Haschemi, Jens Müller, Bernd Pötzsch, Gerd Bendas, Martin Schlesinger
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0191303 (2018)
Metastasis is responsible for the majority of cancer associated fatalities. Tumor cells leaving the primary tumor and entering the blood flow immediately interact with platelets. Activated platelets contribute in different ways to cancer cell surviva
Externí odkaz:
https://doaj.org/article/834b929a77ed4add9009b5a74b6f8117
Autor:
Heiko Rühl, Christina Berens, Anna Winterhagen, Jens Müller, Johannes Oldenburg, Bernd Pötzsch
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145012 (2015)
The objective of this study was to evaluate the elimination kinetics of hemostasis-related biomarkers including the prothrombin activation fragment F1+2, thrombin-antithrombin complex (TAT), plasmin-α2-antiplasmin complex (PAP), and D-dimer in human
Externí odkaz:
https://doaj.org/article/a0ce7b88a52c4ce0a294915c452ebfbe
Autor:
Heiko Rühl, Lars Schröder, Jens Müller, Shorena Sukhitashvili, Julia Welz, Walther C Kuhn, Johannes Oldenburg, Christian Rudlowski, Bernd Pötzsch
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105007 (2014)
The increased thrombotic risk of oral contraceptives (OC) has been attributed to various alterations of the hemostatic system, including acquired resistance to activated protein C (APC). To evaluate to what extent OC-associated APC resistance induces
Externí odkaz:
https://doaj.org/article/1f5a4d85b1704e9892521d18a315397e