Zobrazeno 1 - 10
of 214
pro vyhledávání: '"Bernd Meibohm"'
Autor:
Robin Michelet, Linda B. S. Aulin, Jens M. Borghardt, Teresa Dalla Costa, Paolo Denti, Manuel Ibarra, Guangda Ma, Bernd Meibohm, Goonaseelan (Colin) Pillai, Stephan Schmidt, Stefanie Hennig, Charlotte Kloft
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 6, Pp 743-747 (2023)
Externí odkaz:
https://doaj.org/article/d47a9342018b4215a7fc58031d099e10
Autor:
Keyur R. Parmar, Pradeep B. Lukka, Santosh Wagh, Zaid H. Temrikar, Jiuyu Liu, Richard E. Lee, Miriam Braunstein, Anthony J. Hickey, Gregory T. Robertson, Mercedes Gonzalez-Juarrero, Andrea Edginton, Bernd Meibohm
Publikováno v:
Pharmaceutics, Vol 15, Iss 6, p 1759 (2023)
Spectinamides 1599 and 1810 are lead spectinamide compounds currently under preclinical development to treat multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis. These compounds have previously been tested at various combinati
Externí odkaz:
https://doaj.org/article/e146c5c3fef646658561f95712d507a4
Autor:
Bernd Meibohm
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Therapeutic proteins such as monoclonal antibodies and their derivatives, fusions proteins, hormone analogs and enzymes for replacement therapy are an ever-growing mainstay in our pharmacopoeia. While a growing number of these medications are develop
Externí odkaz:
https://doaj.org/article/88c071274bca4b38bc1270bd509107c0
Autor:
Bing Yang, Robert B Parker, Bernd Meibohm, Zaid H Temrikar, Ashish Srivastava, S Casey Laizure
Publikováno v:
PLoS ONE, Vol 17, Iss 11, p e0278111 (2022)
Dimethyl fumarate (DMF) is a first-line prodrug for the treatment of relapsing-remitting multiple sclerosis (RRMS) that is completely metabolized to monomethyl fumarate (MMF), the active metabolite, before reaching the systemic circulation. Its metab
Externí odkaz:
https://doaj.org/article/0929d5d3f7e143f6b238c74808f1332a
Autor:
Valentina Shakhnovich, Bernd Meibohm, Amy Rosenberg, Andrzej M. Kierzek, Rachel Hasenkamp, Ryan S. Funk, Craig J. Thalhauser, Piet H. van derGraaf, Yow‐Ming C. Wang, Lora Hamuro
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 2, Pp 219-223 (2020)
Externí odkaz:
https://doaj.org/article/7e393e533b14403299f2fb8e170aff30
Autor:
Joseph W. Polli, Christopher R. McCurdy, Dale Eric Wurster, Binodh S. DeSilva, Annette Bak, Reina Bendayan, Bernd Meibohm, Allen C. Templeton, William Weiser, for the AAPS Leadership
Publikováno v:
AAPS Open, Vol 4, Iss 1, Pp 1-4 (2018)
Externí odkaz:
https://doaj.org/article/333fd29abf4e46938308e09081a6149f
Autor:
Karen Santos, Pradeep B. Lukka, Anne Grzegorzewicz, Mary Jackson, Ashit Trivedi, Fernando Pavan, Marlus Chorilli, Miriam Braunstein, Anthony Hickey, Bernd Meibohm, Mercedes Gonzalez-Juarrero
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
There is an urgent need to treat tuberculosis (TB) quickly, effectively and without side effects. Mycobacterium tuberculosis (Mtb), the causative organism of TB, can survive for long periods of time within macrophages and dendritic cells and these in
Externí odkaz:
https://doaj.org/article/474f7a8a8f054cdf9c76928c6f2b5eec
Autor:
Lukas Kovar, Andreas Weber, Michael Zemlin, Yvonne Kohl, Robert Bals, Bernd Meibohm, Dominik Selzer, Thorsten Lehr
Publikováno v:
Pharmaceutics, Vol 12, Iss 10, p 908 (2020)
Fentanyl is widely used for analgesia, sedation, and anesthesia both in adult and pediatric populations. Yet, only few pharmacokinetic studies of fentanyl in pediatrics exist as conducting clinical trials in this population is especially challenging.
Externí odkaz:
https://doaj.org/article/5b434bd5d61e4392b35ce8cbc6571013
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0172628 (2017)
Ethanol consumption is negatively associated with antiretroviral therapy (ART) adherence and general health in HIV positive individuals. Previously, we demonstrated ethanol-mediated alterations to metabolism of elvitegravir (EVG) in human liver micro
Externí odkaz:
https://doaj.org/article/d3312c80ca1147f8bf0ac3082325d0f5
Autor:
Narasimha M Midde, Mohammad A Rahman, Chetan Rathi, Junhao Li, Bernd Meibohm, Weihua Li, Santosh Kumar
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149225 (2016)
Elvitegravir (EVG), an integrase inhibitor for the treatment HIV infection, is increasingly becoming the part of first-line antiretroviral therapy (ART) regimen. EVG is mainly metabolized through cytochrome P450 (CYP) 3A4. Previously, we have shown t
Externí odkaz:
https://doaj.org/article/f45591a32d0849008998d363b5ec4645