Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Bernd L. Sorg"'
Publikováno v:
PLoS ONE, Vol 9, Iss 1 (2014)
Externí odkaz:
https://doaj.org/article/0a0ed386d36045408b2bf18935abe6df
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
Changes in vitamin D serum levels have been associated with inflammatory diseases, such as inflammatory bowel disease, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, atherosclerosis or asthma. Genome- and transcriptome-wide s
Externí odkaz:
https://doaj.org/article/cc79c00448e5457cb9d9fa04c6fd0c58
5‐Lipoxygenase (5‐LO) is the initial enzyme in the biosynthesis of leukotrienes, which are mediators involved in pathophysiological conditions such as asthma and certain cancer types. Knowledge of proteins involved in 5‐LO pathway regulation, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5636196dde1add53cf32b534bbd993eb
https://publica.fraunhofer.de/handle/publica/267000
https://publica.fraunhofer.de/handle/publica/267000
Publikováno v:
Prostaglandins & Other Lipid Mediators. 123:63-67
Epoxyeicosatrienoic acids (EETs) are potent lipid mediators formed by cytochrome P450 epoxygenases from arachidonic acid. They consist of four regioisomers of cis-epoxyeicosatrienoic acids: 5,6-, 8,9-, 11,12- and 14,15-EET. Here we investigated wheth
Autor:
Birger Christensson, Bernd L. Sorg, Olof Rådmark, Yilmaz Mahshid, Magnus Björkholm, Birgitta Sander, Hans-Erik Claesson, Vildan Dincbas-Renqvist, Duran Sürün, Stavroula Markoutsa
Publikováno v:
Prostaglandins, Leukotrienes and Essential Fatty Acids. 100:33-40
The key enzyme in leukotriene (LT) biosynthesis is 5-lipoxygenase (5-LO), which is expressed in myeloid cells and in B lymphocytes. There are three phosphorylation sites on 5-LO (Ser271, Ser523 and Ser663). Protein kinase A (PKA) phosphorylates 5-LO
Autor:
Bernd L. Sorg, Michael Karas, Bettina Hofmann, Duran Sürün, Stavroula Markoutsa, Dieter Steinhilber
Publikováno v:
FEBS Journal. 281:1931-1947
The enzyme 5-lipoxygenase (5-LO) catalyzes the first reactions in the biosynthesis of leukotrienes, powerful lipid mediators that are involved in several physiological and pathological processes. 5-LO activity is tightly regulated by several factors,
Autor:
Bernd L. Sorg, Dimitrios G. Papasotiriou, Stavroula Markoutsa, Ann-Kathrin Häfner, Michael Karas, Ute Bahr
Publikováno v:
PROTEOMICS. 14:659-667
The discovery of PTMs in proteins by MS requires nearly complete sequence coverage of the detected proteolytic peptides. Unfortunately, mass spectrometric analysis of the desired sequence fragments is often impeded due to low ionization efficiency an
Autor:
Kirsten L. Stoffers, Sabine Seuter, Bernd L. Sorg, Olof Rådmark, Oliver Rau, Dieter Steinhilber
Publikováno v:
Journal of Molecular Biology. 395:884-896
5-Lipoxygenase (5-LO) gene expression is strongly upregulated during induction of myeloid cell differentiation by 1alpha,25-dihydroxyvitamin D(3) (calcitriol) and transforming growth factor-beta (TGFbeta) in a promoter-independent manner. In an activ
Autor:
Bernd L. Sorg, Nicole Schnur, Ad Gillis, Careen Katryniok, Andreas von Knethen, Dieter Steinhilber, Olof Rådmark, Leendert H. J. Looijenga
Publikováno v:
Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1801(1), 49-57. Elsevier
Human 5-lipoxygenase (5-LO) is the key enzyme in the formation of inflammatory leukotrienes. 540 gene expression is mainly restricted to B cells and cells of myeloid origin. It is known that basal 5-lipoxygenase promoter activity is regulated by DNA
Publikováno v:
Lindner, S C, Köhl, U, Maier, T, Steinhilber, D & Sorg, B L 2009, ' TLR2 ligands augment cPLA2alpha activity and lead to enhanced leukotriene release in human monocytes ', Journal of Leukocyte Biology, vol. 86, no. 2, pp. 389-99 . https://doi.org/10.1189/jlb.1008591
Increased synthesis of inflammatory eicosanoids can be primed by innate immune receptor activation. Toll-like receptors (TLRs) play an important role in innate immunity. They detect pathogen-associated receptor patterns (PAMPs) and initiate subsequen