Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Bernd Klaus"'
Publikováno v:
eLife, Vol 12 (2023)
Individuals with PhDs and postdoctoral experience in the life sciences can pursue a variety of career paths. Many PhD students and postdocs aspire to a permanent research position at a university or research institute, but competition for such positi
Externí odkaz:
https://doaj.org/article/32a58bea62f74c37afcdb04c94293113
Autor:
Magdalena Zimoń, Yunfeng Huang, Anthi Trasta, Aliaksandr Halavatyi, Jimmy Z. Liu, Chia-Yen Chen, Peter Blattmann, Bernd Klaus, Christopher D. Whelan, David Sexton, Sally John, Wolfgang Huber, Ellen A. Tsai, Rainer Pepperkok, Heiko Runz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Studying the contribution of pairs of genes to complex traits has been challenging. Here, the authors combine exome and genotype data with RNAi to screen for genetic interactions between 30 genes identified in lipid GWAS to hint at pairs whose joint
Externí odkaz:
https://doaj.org/article/2bb3a6e883434f35aa8c3f3734f6d85f
Autor:
Ignacio L. Ibarra, Nele M. Hollmann, Bernd Klaus, Sandra Augsten, Britta Velten, Janosch Hennig, Judith B. Zaugg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Although transcription factor (TF) cooperativity is widespread, a global mechanistic understanding of the role of TF cooperativity is still lacking. Here the authors introduce a statistical learning framework that provides structural insight into TF
Externí odkaz:
https://doaj.org/article/72d38bbd5c5341449dcf400e10a51167
Autor:
Ebru Ercan-Herbst, Jens Ehrig, David C. Schöndorf, Annika Behrendt, Bernd Klaus, Borja Gomez Ramos, Nuria Prat Oriol, Christian Weber, Dagmar E. Ehrnhoefer
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-19 (2019)
Abstract Tau is a microtubule-binding protein that can receive various post-translational modifications (PTMs) including phosphorylation, methylation, acetylation, glycosylation, nitration, sumoylation and truncation. Hyperphosphorylation of tau is l
Externí odkaz:
https://doaj.org/article/b2babf57c14c4605bf6c7338a04d0417
Publikováno v:
Cell Reports, Vol 14, Iss 10, Pp 2463-2475 (2016)
A comprehensive map of transcription start sites (TSSs) across the highly AT-rich genome of P. falciparum would aid progress toward deciphering the molecular mechanisms that underlie the timely regulation of gene expression in this malaria parasite.
Externí odkaz:
https://doaj.org/article/4eeb47ab4bb94f76b1b675f67e41e174
Autor:
Bernd Klaus, Stefanie Reisenauer
Publikováno v:
F1000Research, Vol 5 (2018)
In this article, we walk through an end-to-end Affymetrix microarray differential expression workflow using Bioconductor packages. This workflow is directly applicable to current "Gene'' type arrays, e.g.the HuGene or MoGene arrays, but can easily be
Externí odkaz:
https://doaj.org/article/27699a9d6e4c4c13b9c58d03f6ee355a
Autor:
Gokmen Zararsiz, Dincer Goksuluk, Bernd Klaus, Selcuk Korkmaz, Vahap Eldem, Erdem Karabulut, Ahmet Ozturk
Publikováno v:
PeerJ, Vol 5, p e3890 (2017)
RNA-Seq is a recent and efficient technique that uses the capabilities of next-generation sequencing technology for characterizing and quantifying transcriptomes. One important task using gene-expression data is to identify a small subset of genes th
Externí odkaz:
https://doaj.org/article/1b3f2c4658034acd985c57f49d4c350e
Publikováno v:
PeerJ, Vol 4, p e1981 (2016)
The genome-wide study of epigenetic states requires the integrative analysis of histone modification ChIP-seq data. Here, we introduce an easy-to-use analytic framework to compare profiles of enrichment in histone modifications around classes of geno
Externí odkaz:
https://doaj.org/article/b5823de1c17f4b1b868fd7e5c1d29767
The life sciences are training growing numbers of PhDs and postdocs, who increasingly engage in collaborative research. The impact of these changes on the careers of researchers is, however, unclear. Here, we report an analysis of the training outcom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::152aa10c52952d912a242a81ec2cb036
https://doi.org/10.1101/2022.03.01.481975
https://doi.org/10.1101/2022.03.01.481975
Autor:
Sandra Augsten, Nele Merret Hollmann, Britta Velten, Ignacio L. Ibarra, Janosch Hennig, Bernd Klaus, Judith B. Zaugg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
Recent high-throughput transcription factor (TF) binding assays revealed that TF cooperativity is a widespread phenomenon. However, a global mechanistic and functional understanding of TF cooperativity is still lacking. To address this, here we intro