Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Bernd Kühn"'
Publikováno v:
Stem Cell Research, Vol 81, Iss , Pp 103613- (2024)
Dopaminergic (DA) neurons play critical roles in various neurological processes and disorders, particularly Parkinson’s disease. To enable precise visualization and tracking of DA neurons, we generated TH-EGFP, a tyrosine hydroxylase (TH)-driven en
Externí odkaz:
https://doaj.org/article/f62c5041e0724b16bc2cc4da692ddc5f
Autor:
Julien Dinkel, Grzegorz Bauman, Moritz Schneider, Olaf Dietrich, Thomas Gaass, David Bondesson, Bernd Kühn
Publikováno v:
Magnetic Resonance in Medicine
Purpose To improve the robustness of pulmonary ventilation- and perfusion-weighted imaging with Fourier decomposition (FD) MRI in the presence of respiratory and cardiac frequency variations by replacing the standard fast Fourier transform with the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e8189fc9f1903b4f0faf414eee8c38
http://europepmc.org/articles/PMC6767124
http://europepmc.org/articles/PMC6767124
Autor:
Kenneth Atz, Leandro Cotos, Clemens Isert, Maria Håkansson, Dorota Focht, Mattis Hilleke, David F. Nippa, Michael Iff, Jann Ledergerber, Carl C. G. Schiebroek, Valentina Romeo, Jan A. Hiss, Daniel Merk, Petra Schneider, Bernd Kuhn, Uwe Grether, Gisbert Schneider
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract De novo drug design aims to generate molecules from scratch that possess specific chemical and pharmacological properties. We present a computational approach utilizing interactome-based deep learning for ligand- and structure-based generati
Externí odkaz:
https://doaj.org/article/d7bb743be1dc457aa2795efb9109d361
Autor:
Sumire Honda Malca, Nadine Duss, Jasmin Meierhofer, David Patsch, Michael Niklaus, Stefanie Reiter, Steven Paul Hanlon, Dennis Wetzl, Bernd Kuhn, Hans Iding, Rebecca Buller
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract Semi-rational enzyme engineering is a powerful method to develop industrial biocatalysts. Profiting from advances in molecular biology and bioinformatics, semi-rational approaches can effectively accelerate enzyme engineering campaigns. Here
Externí odkaz:
https://doaj.org/article/59de910ece304113b1624d29bd3d0b40
Autor:
Bashair A Alhummiany, Margaret Saysell, Cherry Coupland, Steven Sourbron, M.W. Mansfield, David L. Buckley, David Shelley, Kelly Wroe, Bernd Kühn, Maria-Alexandra Olaru, Kanishka Sharma, Julie Bailey
Publikováno v:
Journal of Magnetic Resonance Imaging
Background Renal blood flow (RBF) can be measured with dynamic contrast enhanced-MRI (DCE-MRI) and arterial spin labeling (ASL). Unfortunately, individual estimates from both methods vary and reference-standard methods are not available. A potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b792a883f54ae4b966b86ceb56ae15
Autor:
Bernd Kühn, Saba Shirvani, Pawel Tokarczuk, Ben K. Statton, James Tomlinson, Peter Weale, Declan P. O'Regan, Marina Quinlan, Alaine Berry
Publikováno v:
European Radiology
Objectives We investigated the feasibility and reproducibility of free-breathing motion-corrected multiple inversion time (multi-TI) pulsed renal arterial spin labelling (PASL), with general kinetic model parametric mapping, to simultaneously quantif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5182a92e7631c8f549651bf670c83423
https://doi.org/10.1007/s00330-018-5628-3
https://doi.org/10.1007/s00330-018-5628-3
Akademický článek
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Autor:
Melody Li, Bernd Kuhn
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103094- (2024)
Summary: SCN2A loss-of-function variants cause a range of neurodevelopmental disorders. Here, we present a protocol to induce severe Scn2a insufficiency in mice. We describe steps for intracerebroventricular (ICV) antisense oligonucleotide (ASO) inje
Externí odkaz:
https://doaj.org/article/dc49828cd4f647f191ed3c904681b7e8
Autor:
Mujin Yang, Daobin Zhang, Zhifu Yao, Zhen Ma, Junhua Luan, Cuiping Wang, Bernd Kuhn, Zengbao Jiao, Yilu Zhao, Tao Yang, Xingjun Liu, Shuai Wang
Publikováno v:
Journal of Materials Research and Technology, Vol 26, Iss , Pp 9261-9275 (2023)
In this study, G-phase strengthened 7Ni maraging alloys were studied using a combination of thermodynamic prediction based on the TCFE-7 database and advanced experimental techniques, including micro-hardness testing, electron backscatter diffraction
Externí odkaz:
https://doaj.org/article/1b67fd8dc9d54a7b9e34396455cc80af
Autor:
Han-Ying Wang, Hiroshi Takagi, Patrick N. Stoney, Anai Echeverria, Bernd Kuhn, Kuei-Sen Hsu, Tomoyuki Takahashi
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109515- (2024)
Summary: Transient anoxia causes amnesia and neuronal death. This is attributed to enhanced glutamate release and modeled as anoxia-induced long-term potentiation (aLTP). aLTP is mediated by glutamate receptors and nitric oxide (·NO) and occludes st
Externí odkaz:
https://doaj.org/article/1071ce67fe7c4090a1186b026dea20dd