Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Bernd Jablonka"'
Autor:
Andrew A. Brown, Juan J. Fernandez-Tajes, Mun-gwan Hong, Caroline A. Brorsson, Robert W. Koivula, David Davtian, Théo Dupuis, Ambra Sartori, Theodora-Dafni Michalettou, Ian M. Forgie, Jonathan Adam, Kristine H. Allin, Robert Caiazzo, Henna Cederberg, Federico De Masi, Petra J. M. Elders, Giuseppe N. Giordano, Mark Haid, Torben Hansen, Tue H. Hansen, Andrew T. Hattersley, Alison J. Heggie, Cédric Howald, Angus G. Jones, Tarja Kokkola, Markku Laakso, Anubha Mahajan, Andrea Mari, Timothy J. McDonald, Donna McEvoy, Miranda Mourby, Petra B. Musholt, Birgitte Nilsson, Francois Pattou, Deborah Penet, Violeta Raverdy, Martin Ridderstråle, Luciana Romano, Femke Rutters, Sapna Sharma, Harriet Teare, Leen ‘t Hart, Konstantinos D. Tsirigos, Jagadish Vangipurapu, Henrik Vestergaard, Søren Brunak, Paul W. Franks, Gary Frost, Harald Grallert, Bernd Jablonka, Mark I. McCarthy, Imre Pavo, Oluf Pedersen, Hartmut Ruetten, Mark Walker, The DIRECT Consortium, Jerzy Adamski, Jochen M. Schwenk, Ewan R. Pearson, Emmanouil T. Dermitzakis, Ana Viñuela
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract We evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity, where multiple variants regulate a particular molecular phenotype,
Externí odkaz:
https://doaj.org/article/03b888dddec54ecd93647492ab5dd5aa
Autor:
Morgan Obura, Joline W J Beulens, Roderick Slieker, Anitra D M Koopman, Trynke Hoekstra, Giel Nijpels, Petra Elders, Robert W Koivula, Azra Kurbasic, Markku Laakso, Tue H Hansen, Martin Ridderstråle, Torben Hansen, Imre Pavo, Ian Forgie, Bernd Jablonka, Hartmut Ruetten, Andrea Mari, Mark I McCarthy, Mark Walker, Alison Heggie, Timothy J McDonald, Mandy H Perry, Federico De Masi, Søren Brunak, Anubha Mahajan, Giuseppe N Giordano, Tarja Kokkola, Emmanouil Dermitzakis, Ana Viñuela, Oluf Pedersen, Jochen M Schwenk, Jurek Adamski, Harriet J A Teare, Ewan R Pearson, Paul W Franks, Leen M 't Hart, Femke Rutters, IMI-DIRECT Consortium
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0242360 (2020)
AimSubclasses of different glycaemic disturbances could explain the variation in characteristics of individuals with type 2 diabetes (T2D). We aimed to examine the association between subgroups based on their glucose curves during a five-point mixed-
Externí odkaz:
https://doaj.org/article/fa28468aa1134da49de7b42ba239579c
Autor:
Petra J. M. Elders, Andrea Mari, Femke Rutters, Musholt P, Caiazzo R, Ana Viñuela, Harriet Teare, Fernandez J, H Grallert, McEvoy D, Kristine H. Allin, Pattou F, Jochen M. Schwenk, Pavo I, Mourby M, Dupuis T, Giuseppe N. Giordano, Tarja Kokkola, Andrew T. Hattersley, Adam J, Jagadish Vangipurapu, Ian M Forgie, Anubha Mahajan, Cédric Howald, Caroline Brorsson, Adamski J, Henrik Vestergaard, Gary Frost, Emmanouil T. Dermitzakis, Thomas Willum Hansen, Alison Heggie, Deborah Penet, Sapna Sharma, McDonald Tj, Mark Haid, De Masi F, Raverdy, Bernd Jablonka, Paul W. Franks, Robert W. Koivula, Andrew A. Brown, Søren Brunak, Mark I. McCarthy, Konstantinos D. Tsirigos, Angus G. Jones, Ridderstrale M, Mun-Gwan Hong, E R Pearson, Markku Laakso, Birgitte Nilsson, Davtian D, T’Hart Lm, Walker M, Oluf Pedersen, Ruetten H, Henna Cederberg, Luciana Romano
Genetic variants identified by genome-wide association studies can contribute to disease risk by altering the production and abundance of mRNA, proteins and other molecules. However, the interplay between molecular intermediaries that define the path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b140e9ddef00dc40c94154233c60821b
https://doi.org/10.1101/2021.03.26.21254347
https://doi.org/10.1101/2021.03.26.21254347
Autor:
Emil K. Rydzka, Søren Brunak, Karina Banasik, Ian M Forgie, Timothy J. McDonald, Jacqueline W. M. Postma, Ramneek Gupta, Harriet Teare, Anna Barnett, Bernd Jablonka, Sanna Herrgard, Jane Kaye, Federico De Masi, Piotr Jaroslaw Chmura, Ewan R. Pearson
Publikováno v:
Life Sciences, Society and Policy, Vol 14, Iss 1, Pp 1-17 (2018)
Teare, H J A, de Masi, F, Banasik, K, Barnett, A, Herrgard, S, Jablonka, B, Postma, J W M, McDonald, T J, Forgie, I, Chmura, P J, Rydzka, E K, Gupta, R, Brunak, S, Pearson, E & Kaye, J 2018, ' The governance structure for data access in the DIRECT consortium : an innovative medicines initiative (IMI) project ', Life Sciences, Society and Policy, vol. 14, no. 1, 20, pp. 1-17 . https://doi.org/10.1186/s40504-018-0083-0
Teare, H J A, De Masi, F, Banasik, K, Barnett, A, Herrgard, S, Jablonka, B, Postma, J W M, McDonald, T J, Forgie, I, Chmura, P J, Rydzka, E K, Gupta, R, Brunak, S, Pearson, E & Kaye, J 2018, ' The governance structure for data access in the DIRECT consortium: an innovative medicines initiative (IMI) project ', Life Sciences, Society and Policy, vol. 14, 20 . https://doi.org/10.1186/s40504-018-0083-0
Teare, H J A, de Masi, F, Banasik, K, Barnett, A, Herrgard, S, Jablonka, B, Postma, J W M, McDonald, T J, Forgie, I, Chmura, P J, Rydzka, E K, Gupta, R, Brunak, S, Pearson, E & Kaye, J 2018, ' The governance structure for data access in the DIRECT consortium : an innovative medicines initiative (IMI) project ', Life Sciences, Society and Policy, vol. 14, no. 1, 20, pp. 1-17 . https://doi.org/10.1186/s40504-018-0083-0
Teare, H J A, De Masi, F, Banasik, K, Barnett, A, Herrgard, S, Jablonka, B, Postma, J W M, McDonald, T J, Forgie, I, Chmura, P J, Rydzka, E K, Gupta, R, Brunak, S, Pearson, E & Kaye, J 2018, ' The governance structure for data access in the DIRECT consortium: an innovative medicines initiative (IMI) project ', Life Sciences, Society and Policy, vol. 14, 20 . https://doi.org/10.1186/s40504-018-0083-0
Biomedical research projects involving multiple partners from public and private sectors require coherent internal governance mechanisms to engender good working relationships. The DIRECT project is an example of such a venture, funded by the Innovat
Autor:
Roderick C. Slieker, Imre Pavo, Tue H. Hansen, Thomas Willum Hansen, Martin Ridderstråle, A. Mari, Leen M 't Hart, Morgan Obura, Femke Rutters, Ian M Forgie, Giel Nijpels, Joline W.J. Beulens, Petra J. M. Elders, Timothy J. McDonald, Hartmut Ruetten, J. M. Dekker, Robert W. Koivula, Mark Walker, Markku Laakso, Trynke Hoekstra, Ewan R. Pearson, Mandy H Perry, Anitra D.M. Koopman, Mark I. McCarthy, Azra Kurbasic, Paul W. Franks, Bernd Jablonka
Publikováno v:
Obura, M, Beulens, J W J, Nijpels, G, Elders, P & IMI-DIRECT Consortium 2021, ' Clinical profiles of post-load glucose subgroups and their association with glycaemic traits over time: An IMI-DIRECT study ', Diabetic Medicine, vol. 38, no. 2, e14428 . https://doi.org/10.1111/dme.14428
Obura, M, Beulens, J W J, Slieker, R, Koopman, A D M, Hoekstra, T, Nijpels, G, Elders, P, Dekker, J M, Koivula, R W, Kurbasic, A, Laakso, M, Hansen, T H, Ridderstråle, M, Hansen, T, Pavo, I, Forgie, I, Jablonka, B, Ruetten, H, Mari, A, McCarthy, M I, Walker, M, McDonald, T J, Perry, M H, Pearson, E R, Franks, P W, 't Hart, L M & Rutters, F 2021, ' Clinical profiles of post-load glucose subgroups and their association with glycaemic traits over time : An IMI-DIRECT study ', Diabetic Medicine, vol. 38, no. 2, 14428 . https://doi.org/10.1111/dme.14428
the IMI-DIRECT Consortium 2021, ' Clinical profiles of post-load glucose subgroups and their association with glycaemic traits over time : An IMI-DIRECT study ', Diabetic Medicine, vol. 38, no. 2, e14428 . https://doi.org/10.1111/dme.14428
Diabetic Medicine, 38(2). WILEY
Diabetic Medicine, 38(2):e14428. Wiley-Blackwell
Obura, M, Beulens, J W J, Slieker, R, Koopman, A D M, Hoekstra, T, Nijpels, G, Elders, P, Dekker, J M, Koivula, R W, Kurbasic, A, Laakso, M, Hansen, T H, Ridderstråle, M, Hansen, T, Pavo, I, Forgie, I, Jablonka, B, Ruetten, H, Mari, A, McCarthy, M I, Walker, M, McDonald, T J, Perry, M H, Pearson, E R, Franks, P W, ‘t Hart, L M, Rutters, F & for the IMI DIRECT Consortium 2021, ' Clinical profiles of post-load glucose subgroups and their association with glycaemic traits over time : An IMI-DIRECT study ', Diabetic Medicine, vol. 38, no. 2, e14428 . https://doi.org/10.1111/dme.14428
Diabetic Medicine, 38(2):e14428. Wiley-Blackwell Publishing
Obura, M, Beulens, J W J, Slieker, R, Koopman, A D M, Hoekstra, T, Nijpels, G, Elders, P, Dekker, J M, Koivula, R W, Kurbasic, A, Laakso, M, Hansen, T H, Ridderstråle, M, Hansen, T, Pavo, I, Forgie, I, Jablonka, B, Ruetten, H, Mari, A, McCarthy, M I, Walker, M, McDonald, T J, Perry, M H, Pearson, E R, Franks, P W, 't Hart, L M & Rutters, F 2021, ' Clinical profiles of post-load glucose subgroups and their association with glycaemic traits over time : An IMI-DIRECT study ', Diabetic Medicine, vol. 38, no. 2, 14428 . https://doi.org/10.1111/dme.14428
the IMI-DIRECT Consortium 2021, ' Clinical profiles of post-load glucose subgroups and their association with glycaemic traits over time : An IMI-DIRECT study ', Diabetic Medicine, vol. 38, no. 2, e14428 . https://doi.org/10.1111/dme.14428
Diabetic Medicine, 38(2). WILEY
Diabetic Medicine, 38(2):e14428. Wiley-Blackwell
Obura, M, Beulens, J W J, Slieker, R, Koopman, A D M, Hoekstra, T, Nijpels, G, Elders, P, Dekker, J M, Koivula, R W, Kurbasic, A, Laakso, M, Hansen, T H, Ridderstråle, M, Hansen, T, Pavo, I, Forgie, I, Jablonka, B, Ruetten, H, Mari, A, McCarthy, M I, Walker, M, McDonald, T J, Perry, M H, Pearson, E R, Franks, P W, ‘t Hart, L M, Rutters, F & for the IMI DIRECT Consortium 2021, ' Clinical profiles of post-load glucose subgroups and their association with glycaemic traits over time : An IMI-DIRECT study ', Diabetic Medicine, vol. 38, no. 2, e14428 . https://doi.org/10.1111/dme.14428
Diabetic Medicine, 38(2):e14428. Wiley-Blackwell Publishing
© 2020 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UKAim: To examine the hypothesis that, based on their glucose curves during a seven-point oral glucose tolerance test, people at elevated type 2 diabetes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9de591531c18b445cb2a4b530c9647b
https://research.vumc.nl/en/publications/db90adc2-3c87-4bb8-b1fc-6b324a25aeec
https://research.vumc.nl/en/publications/db90adc2-3c87-4bb8-b1fc-6b324a25aeec
Autor:
Natalie R. van Zuydam, Alexander Stiby, Moustafa Abdalla, Erin Austin, Emma H. Dahlström, Stela McLachlan, Efthymia Vlachopoulou, Emma Ahlqvist, Chen Di Liao, Niina Sandholm, Carol Forsblom, Anubha Mahajan, Neil R. Robertson, N. William Rayner, Eero Lindholm, Juha Sinisalo, Markus Perola, Milla Kallio, Emily Weiss, Jackie Price, Andrew Paterson, Barbara Klein, Veikko Salomaa, Colin N.A. Palmer, Per-Henrik Groop, Leif Groop, Mark I. McCarthy, Mariza de Andrade, Andrew P. Morris, Jemma C. Hopewell, Helen M. Colhoun, Iftikhar J. Kullo, Sólveig Grétarsdóttir, Guðmar Þorleifsson, Unnur þorsteinsdóttir, Kari Stefansson, Michael Mark, Timo Kanninen, Barbara Thorand, Giuseppe Remuzzi, David Dunger, Angela Shore, Ulf Smith, Seppo Ylä-Herttuala, Claudio Cobelli, Riccardo Bellazzi, Ele Ferrannini, Carlo Patrono, Pirjo Nuutila, Paul McKeague, Birgit Steckel-Hamann, Li-ming Gan, Everson Nogoceke, Piero Tortoli, Bernd Jablonka, Mary-Julia Brosnan
Publikováno v:
Circulation. Genomic and Precision Medicine
Van Zuydam, N R, Stiby, A, Abdalla, M, Dahlstrom, EH, McLachlan, S, Vlachopoulou, E, Price, J F, Ahlqvist, E, Di Liao, C, Sandholm, N, Forsblom, C, Mahajan, A, Robertson, N R, Rayner, N W, Lindholm, E, Sinisalo, J, Perola, M, Kallio, M, Weiss, E, Paterson, A, Klein, B, Salomaa, V, McCarthy, M, de Andrade, M, Morris, AP, Hopewell, JC, Colhoun, H M & Kullo, IJ 2021, ' A genome-wide association study of peripheral artery disease ', Circulation: Genomic and Precision Medicine . https://doi.org/10.1161/CIRCGEN.119.002862
Circ. Genom. Precis. Med. 14:e002862 (2021)
Circulation: Genomic and Precision Medicine
Van Zuydam, N R, Stiby, A, Abdalla, M, Dahlstrom, EH, McLachlan, S, Vlachopoulou, E, Price, J F, Ahlqvist, E, Di Liao, C, Sandholm, N, Forsblom, C, Mahajan, A, Robertson, N R, Rayner, N W, Lindholm, E, Sinisalo, J, Perola, M, Kallio, M, Weiss, E, Paterson, A, Klein, B, Salomaa, V, McCarthy, M, de Andrade, M, Morris, AP, Hopewell, JC, Colhoun, H M & Kullo, IJ 2021, ' A genome-wide association study of peripheral artery disease ', Circulation: Genomic and Precision Medicine . https://doi.org/10.1161/CIRCGEN.119.002862
Circ. Genom. Precis. Med. 14:e002862 (2021)
Circulation: Genomic and Precision Medicine
Supplemental Digital Content is available in the text.
Background: Peripheral artery disease (PAD) affects >200 million people worldwide and is associated with high mortality and morbidity. We sought to identify genomic variants associated with
Background: Peripheral artery disease (PAD) affects >200 million people worldwide and is associated with high mortality and morbidity. We sought to identify genomic variants associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1331a7c40e7d9286577d43c5d5fbb16a
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-458405
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-458405
Autor:
Petra J. M. Elders, Ana Viñuela, Roderick C. Slieker, Søren Brunak, Anitra D.M. Koopman, Torben Hansen, Femke Rutters, Martin Ridderstråle, Trynke Hoekstra, Andrea Mari, Bernd Jablonka, Ewan R. Pearson, Oluf Pedersen, Jurek Adamski, Tarja Kokkola, Giel Nijpels, Morgan Obura, Markku Laakso, Tue H. Hansen, Anubha Mahajan, Mandy H Perry, Leen M 't Hart, Hartmut Ruetten, Robert W. Koivula, Giuseppe N. Giordano, Azra Kurbasic, Jochen M. Schwenk, Emmanouil T. Dermitzakis, Mark I. McCarthy, Ian M Forgie, Timothy J. McDonald, Harriet Teare, Mark Walker, Federico De Masi, Alison Heggie, Paul W. Franks, Joline W.J. Beulens, Imre Pavo
Publikováno v:
PLoS ONE
Obura, M, Beulens, J W J, Slieker, R, Koopman, A D M, Hoekstra, T, Nijpels, G, Elders, P, Koivula, R W, Kurbasic, A, Laakso, M, Hansen, T H, Ridderstråle, M, Hansen, T, Pavo, I, Forgie, I, Jablonka, B, Ruetten, H, Mari, A, McCarthy, M I, Walker, M, Heggie, A, McDonald, T J, Perry, M H, De Masi, F, Brunak, S, Mahajan, A, Giordano, G N, Kokkola, T, Dermitzakis, E, Viñuela, A, Pedersen, O, Schwenk, J M, Adamski, J, Teare, H J A, Pearson, E R, Franks, P W, Hart, L M T, Rutters, F & for the IMI-DIRECT Consortium 2020, ' Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes : An IMI-DIRECT study ', PLoS ONE, vol. 15, no. 11, e0242360 . https://doi.org/10.1371/journal.pone.0242360
PLoS ONE, 15(11). PUBLIC LIBRARY SCIENCE
Obura, M, Beulens, J W J, Nijpels, G, Elders, P & IMI-DIRECT Consortium 2020, ' Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study ', PLoS ONE, vol. 15, no. 11 November, e0242360 . https://doi.org/10.1371/journal.pone.0242360
PLoS ONE, 15(11 November):e0242360. Public Library of Science
PLoS ONE, 15(11):e0242360. Public Library of Science
Obura, M, Beulens, J W J, Slieker, R, Koopman, A D M, Hoekstra, T, Nijpels, G, Elders, P, Koivula, R W, Kurbasic, A, Laakso, M, Hansen, T H, Ridderstråle, M, Hansen, T, Pavo, I, Forgie, I, Jablonka, B, Ruetten, H, Mari, A, McCarthy, M I, Walker, M, Heggie, A, McDonald, T J, Perry, M H, de Masi, F, Brunak, S, Mahajan, A, Giordano, G N, Kokkola, T, Dermitzakis, E, Viñuela, A, Pedersen, O, Schwenk, J M, Adamski, J, Teare, H J A, Pearson, E R, Franks, P W, Hart, L M T & Rutters, F 2020, ' Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes : An IMI-DIRECT study ', PLOS ONE, vol. 15, no. 11 November, e0242360 . https://doi.org/10.1371/journal.pone.0242360
Obura, M, Beulens, J W J, Slieker, R, Koopman, A D M, Hoekstra, T, Nijpels, G, Elders, P, Koivula, R W, Kurbasic, A, Laakso, M, Hansen, T H, Ridderstråle, M, Hansen, T, Pavo, I, Forgie, I, Jablonka, B, Ruetten, H, Mari, A, McCarthy, M I, Walker, M, Heggie, A, McDonald, T J, Perry, M H, De Masi, F, Brunak, S, Mahajan, A, Giordano, G N, Kokkola, T, Dermitzakis, E, Viñuela, A, Pedersen, O, Schwenk, J M, Adamski, J, Teare, H J A, Pearson, E R, Franks, P W, 't Hart, L M, Rutters, F & IMI-DIRECT consortium 2020, ' Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes : An IMI-DIRECT study ', PLOS ONE, vol. 15, no. 11, e0242360 . https://doi.org/10.1371/journal.pone.0242360
PLoS ONE, Vol 15, Iss 11, p e0242360 (2020)
IMI-DIRECT Consortium 2020, ' Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes : An IMI-DIRECT study ', PLoS ONE, vol. 15, no. 11, e0242360, pp. e0242360 . https://doi.org/10.1371/journal.pone.0242360
Obura, M, Beulens, J W J, Slieker, R, Koopman, A D M, Hoekstra, T, Nijpels, G, Elders, P, Koivula, R W, Kurbasic, A, Laakso, M, Hansen, T H, Ridderstråle, M, Hansen, T, Pavo, I, Forgie, I, Jablonka, B, Ruetten, H, Mari, A, McCarthy, M I, Walker, M, Heggie, A, McDonald, T J, Perry, M H, De Masi, F, Brunak, S, Mahajan, A, Giordano, G N, Kokkola, T, Dermitzakis, E, Viñuela, A, Pedersen, O, Schwenk, J M, Adamski, J, Teare, H J A, Pearson, E R, Franks, P W, Hart, L M T, Rutters, F & for the IMI-DIRECT Consortium 2020, ' Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes : An IMI-DIRECT study ', PLoS ONE, vol. 15, no. 11, e0242360 . https://doi.org/10.1371/journal.pone.0242360
PLoS ONE, 15(11). PUBLIC LIBRARY SCIENCE
Obura, M, Beulens, J W J, Nijpels, G, Elders, P & IMI-DIRECT Consortium 2020, ' Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study ', PLoS ONE, vol. 15, no. 11 November, e0242360 . https://doi.org/10.1371/journal.pone.0242360
PLoS ONE, 15(11 November):e0242360. Public Library of Science
PLoS ONE, 15(11):e0242360. Public Library of Science
Obura, M, Beulens, J W J, Slieker, R, Koopman, A D M, Hoekstra, T, Nijpels, G, Elders, P, Koivula, R W, Kurbasic, A, Laakso, M, Hansen, T H, Ridderstråle, M, Hansen, T, Pavo, I, Forgie, I, Jablonka, B, Ruetten, H, Mari, A, McCarthy, M I, Walker, M, Heggie, A, McDonald, T J, Perry, M H, de Masi, F, Brunak, S, Mahajan, A, Giordano, G N, Kokkola, T, Dermitzakis, E, Viñuela, A, Pedersen, O, Schwenk, J M, Adamski, J, Teare, H J A, Pearson, E R, Franks, P W, Hart, L M T & Rutters, F 2020, ' Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes : An IMI-DIRECT study ', PLOS ONE, vol. 15, no. 11 November, e0242360 . https://doi.org/10.1371/journal.pone.0242360
Obura, M, Beulens, J W J, Slieker, R, Koopman, A D M, Hoekstra, T, Nijpels, G, Elders, P, Koivula, R W, Kurbasic, A, Laakso, M, Hansen, T H, Ridderstråle, M, Hansen, T, Pavo, I, Forgie, I, Jablonka, B, Ruetten, H, Mari, A, McCarthy, M I, Walker, M, Heggie, A, McDonald, T J, Perry, M H, De Masi, F, Brunak, S, Mahajan, A, Giordano, G N, Kokkola, T, Dermitzakis, E, Viñuela, A, Pedersen, O, Schwenk, J M, Adamski, J, Teare, H J A, Pearson, E R, Franks, P W, 't Hart, L M, Rutters, F & IMI-DIRECT consortium 2020, ' Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes : An IMI-DIRECT study ', PLOS ONE, vol. 15, no. 11, e0242360 . https://doi.org/10.1371/journal.pone.0242360
PLoS ONE, Vol 15, Iss 11, p e0242360 (2020)
IMI-DIRECT Consortium 2020, ' Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes : An IMI-DIRECT study ', PLoS ONE, vol. 15, no. 11, e0242360, pp. e0242360 . https://doi.org/10.1371/journal.pone.0242360
Aim Subclasses of different glycaemic disturbances could explain the variation in characteristics of individuals with type 2 diabetes (T2D). We aimed to examine the association between subgroups based on their glucose curves during a five-point mixed
Autor:
Natalie R. van Zuydam, Claes Ladenvall, Benjamin F. Voight, Rona J. Strawbridge, Juan Fernandez-Tajes, N. William Rayner, Neil R. Robertson, Anubha Mahajan, Efthymia Vlachopoulou, Anuj Goel, Marcus E. Kleber, Christopher P. Nelson, Lydia Coulter Kwee, Tõnu Esko, Evelin Mihailov, Reedik Mägi, Lili Milani, Krista Fischer, Stavroula Kanoni, Jitender Kumar, Ci Song, Jaana A. Hartiala, Nancy L. Pedersen, Markus Perola, Christian Gieger, Annette Peters, Liming Qu, Sara M. Willems, Alex S.F. Doney, Andrew D. Morris, Yan Zheng, Giorgio Sesti, Frank B. Hu, Lu Qi, Markku Laakso, Unnur Thorsteinsdottir, Harald Grallert, Cornelia van Duijn, Muredach P. Reilly, Erik Ingelsson, Panos Deloukas, Sek Kathiresan, Andres Metspalu, Svati H. Shah, Juha Sinisalo, Veikko Salomaa, Anders Hamsten, Nilesh J. Samani, Winfried März, Stanley L. Hazen, Hugh Watkins, Danish Saleheen, Andrew P. Morris, Helen M. Colhoun, Leif Groop, Mark I. McCarthy, Colin N.A. Palmer, John Danesh, Jeanette Erdmann, Dongfeng Gu, Jaspal S. Kooner, Robert Roberts, Heribert Schunkert, Themistocles L. Assimes, Stefan Blankenberg, Bernhard O. Boehm, John C. Chambers, Robert Clarke, Rory Collins, George Dedoussis, Paul W. Franks, G. Kees Hovingh, Bong-Jo Kim, Terho Lehtimäki, Ruth McPherson, Markku S Nieminen, Christopher O’Donnell, Samuli Ripatti, Manjinder S Sandhu, Stefan Schreiber, Agneta Siegbahn, Cristen J. Willer, Pierre A. Zalloua, Michael Mark, Timo Kanninen, Barbara Thorand, Giuseppe Remuzzi, David Dunger, Angela Shore, Ulf Smith, Per-Henrik Groop, Seppo Ylä-Herttuala, Claudio Cobelli, Riccardo Bellazzi, Ele Ferrannini, Carlo Patrono, Pirjo Nuutila, Paul McKeague, Birgit Steckel-Hamann, Li-ming Gan, Everson Nogoceke, Piero Tortoli, Bernd Jablonka, Mary-Julia Brosnan
Publikováno v:
Circ. Genom. Precis. Med. 13, 640-648 (2020)
Van Zuydam, N R, Ladenvall, C, Voight, B F, Strawbridge, R J, Fernandez-tajes, J, Rayner, N W, Robertson, N R, Mahajan, A, Vlachopoulou, E, Goel, A, Kleber, M E, Nelson, C P, Kwee, L C, Esko, T, Mihailov, E, Mägi, R, Milani, L, Fischer, K, Kanoni, S, Kumar, J, Song, C, Hartiala, J A, Pedersen, N L, Perola, M, Gieger, C, Peters, A, Qu, L, Willems, S M, Doney, A S F, Morris, A P, Zheng, Y, Sesti, G, Hu, F B, Qi, L, Laakso, M, Thorsteinsdottir, U, Grallert, H, Van Duijn, C, Reilly, M P, Ingelsson, E, Deloukas, P, Kathiresan, S, Metspalu, A, Shah, S H, Sinisalo, J, Salomaa, V, Hamsten, A, Samani, N J, März, W, Hazen, S L, Watkins, H, Saleheen, D, Morris, A P, Colhoun, H M, Groop, L, Mccarthy, M I, Palmer, C N A, Danesh, J, Erdmann, J, Gu, D, Kooner, J S, Roberts, R, Schunkert, H, Assimes, T L, Blankenberg, S, Boehm, B O, Chambers, J C, Clarke, R, Collins, R, Dedoussis, G, Franks, P W, Hovingh, G K, Kim, B, Lehtimäki, T, Mcpherson, R, Nieminen, M S, O’donnell, C, Ripatti, S, Sandhu, M S, Schreiber, S, Siegbahn, A, Willer, C J, Zalloua, P A, Mark, M, Kanninen, T, Thorand, B, Remuzzi, G, Dunger, D, Shore, A, Smith, U, Groop, P, Ylä-herttuala, S, Cobelli, C, Bellazzi, R, Ferrannini, E, Patrono, C, Nuutila, P, Mckeague, P, Steckel-hamann, B, Gan, L, Nogoceke, E, Tortoli, P, Jablonka, B & Brosnan, M 2020, ' Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus ', Circulation: Genomic and precision medicine, vol. 13, no. 6 . https://doi.org/10.1161/CIRCGEN.119.002769
2020, ' Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus ', Circulation: Genomic and Precision Medicine, vol. 13, no. 6, pp. e002769 . https://doi.org/10.1161/CIRCGEN.119.002769
Circulation. Genomic and Precision Medicine
Circulation-Genomic and Precision Medicine, 13(6), 640-648. Lippincott Williams & Wilkins
Van Zuydam, N R, Ladenvall, C, Voight, B F, Strawbridge, R J, Fernandez-tajes, J, Rayner, N W, Robertson, N R, Mahajan, A, Vlachopoulou, E, Goel, A, Kleber, M E, Nelson, C P, Kwee, L C, Esko, T, Mihailov, E, Mägi, R, Milani, L, Fischer, K, Kanoni, S, Kumar, J, Song, C, Hartiala, J A, Pedersen, N L, Perola, M, Gieger, C, Peters, A, Qu, L, Willems, S M, Doney, A S F, Morris, A P, Zheng, Y, Sesti, G, Hu, F B, Qi, L, Laakso, M, Thorsteinsdottir, U, Grallert, H, Van Duijn, C, Reilly, M P, Ingelsson, E, Deloukas, P, Kathiresan, S, Metspalu, A, Shah, S H, Sinisalo, J, Salomaa, V, Hamsten, A, Samani, N J, März, W, Hazen, S L, Watkins, H, Saleheen, D, Morris, A P, Colhoun, H M, Groop, L, Mccarthy, M I, Palmer, C N A, Danesh, J, Erdmann, J, Gu, D, Kooner, J S, Roberts, R, Schunkert, H, Assimes, T L, Blankenberg, S, Boehm, B O, Chambers, J C, Clarke, R, Collins, R, Dedoussis, G, Franks, P W, Hovingh, G K, Kim, B, Lehtimäki, T, Mcpherson, R, Nieminen, M S, O’donnell, C, Ripatti, S, Sandhu, M S, Schreiber, S, Siegbahn, A, Willer, C J, Zalloua, P A, Mark, M, Kanninen, T, Thorand, B, Remuzzi, G, Dunger, D, Shore, A, Smith, U, Groop, P, Ylä-herttuala, S, Cobelli, C, Bellazzi, R, Ferrannini, E, Patrono, C, Nuutila, P, Mckeague, P, Steckel-hamann, B, Gan, L, Nogoceke, E, Tortoli, P, Jablonka, B & Brosnan, M 2020, ' Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus ', Circulation: Genomic and precision medicine, vol. 13, no. 6 . https://doi.org/10.1161/CIRCGEN.119.002769
2020, ' Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus ', Circulation: Genomic and Precision Medicine, vol. 13, no. 6, pp. e002769 . https://doi.org/10.1161/CIRCGEN.119.002769
Circulation. Genomic and Precision Medicine
Circulation-Genomic and Precision Medicine, 13(6), 640-648. Lippincott Williams & Wilkins
Supplemental Digital Content is available in the text.
Background: Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D). Methods: To test whether this reflects differential genetic influences on CAD risk i
Background: Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D). Methods: To test whether this reflects differential genetic influences on CAD risk i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c110178bdcbf867d2320b1757655095
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=60858
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=60858
Autor:
Azra Kurbasic, Femke Rutters, Markku Laakso, Joline W.J. Beulens, Caroline Brorsson, Mark Walker, Tarja Kokkola, Emmanouil T. Dermitzakis, Gary Frost, Andrew T. Hattersley, Hartmut Ruetten, Søren Brunak, Simone P. Rauh, Federico De Masi, Ramneek Gupta, Imre Pavo, Christopher J. Groves, Jerzy Adamski, Andrea Tura, Bernd Jablonka, Alison Heggie, Tue H. Hansen, Ana Viñuela, Martin Ridderstråle, Andrea Mari, Jane Kaye, Henrik Vestergaard, Robert W. Koivula, Kristine H. Allin, Harriet Teare, Michelle Hudson, Thomas E. White, Jochen M. Schwenk, Mark I. McCarthy, Maritta Siloaho, Mandy H Perry, Ewan R. Pearson, Oluf Pedersen, Ian M Forgie, Timothy J. McDonald, Soren Brage, Anubha Mahajan, E. Louise Thomas, Paul W. Franks, Anitra D.M. Koopman, Philippe Froguel, Torben Hansen, Jimmy D. Bell, Giuseppe N. Giordano, Adem Y. Dawed
Publikováno v:
Koivula, R W, Forgie, I M, Kurbasic, A, Viñuela, A, Heggie, A, Giordano, G N, Hansen, T H, Hudson, M, Koopman, A D M, Rutters, F, Siloaho, M, Allin, K H, Brage, S R, Brorsson, C A, Dawed, A Y, de Masi, F, Groves, C J, Kokkola, T, Mahajan, A, Perry, M H, Rauh, S P, Ridderstråle, M, Teare, H J A, Thomas, E L, Tura, A, Vestergaard, H, White, T, Adamski, J, Bell, J D, Beulens, J W, Brunak, S R, Dermitzakis, E T, Froguel, P, Frost, G, Gupta, R, Hansen, T, Hattersley, A, Jablonka, B, Kaye, J, Laakso, M, McDonald, T J, Pedersen, O, Schwenk, J M, Pavo, I, Mari, A, McCarthy, M I, Ruetten, H, Walker, M, Pearson, E, Franks, P W & IMI DIRECT Consortium 2019, ' Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium ', Diabetologia, vol. 62, no. 9, pp. 1601-1615 . https://doi.org/10.1007/s00125-019-4906-1
Koivula, R W, Forgie, I M, Kurbasic, A, Viñuela, A, Heggie, A, Giordano, G N, Hansen, T H, Hudson, M, Koopman, A D M, Rutters, F, Siloaho, M, Allin, K H, Brage, S, Brorsson, C A, Dawed, A Y, De Masi, F, Groves, C J, Kokkola, T, Mahajan, A, Perry, M H, Rauh, S P, Ridderstråle, M, Teare, H J A, Thomas, E L, Tura, A, Vestergaard, H, White, T, Adamski, J, Bell, J D, Beulens, J W, Brunak, S, Dermitzakis, E T, Froguel, P, Frost, G, Gupta, R, Hansen, T, Hattersley, A, Jablonka, B, Kaye, J, Laakso, M, McDonald, T J, Pedersen, O, Schwenk, J M, Pavo, I, Mari, A, McCarthy, M I, Ruetten, H, Walker, M, Pearson, E, Franks, P W & IMI-DIRECT consortium 2019, ' Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes : descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium ', Diabetologia, vol. 62, no. 9, pp. 1601-1615 . https://doi.org/10.1007/s00125-019-4906-1
Diabetologia
Diabetologia, Vol. 62, No 9 (2019) pp. 1601-1615
Diabetologia, 62(9), 1601-1615. Springer Verlag
Diabetologia 62, 1601-1615 (2019)
Koivula, R W, Forgie, I M, Kurbasic, A, Viñuela, A, Heggie, A, Giordano, G N, Hansen, T H, Hudson, M, Koopman, A D M, Rutters, F, Siloaho, M, Allin, K H, Brage, S, Brorsson, C A, Dawed, A Y, De Masi, F, Groves, C J, Kokkola, T, Mahajan, A, Perry, M H, Rauh, S P, Ridderstråle, M, Teare, H J A, Thomas, E L, Tura, A, Vestergaard, H, White, T, Adamski, J, Bell, J D, Beulens, J W, Brunak, S, Dermitzakis, E T, Froguel, P, Frost, G, Gupta, R, Hansen, T, Hattersley, A, Jablonka, B, Kaye, J, Laakso, M, McDonald, T J, Pedersen, O, Schwenk, J M, Pavo, I, Mari, A, McCarthy, M I, Ruetten, H, Walker, M, Pearson, E, Franks, P W & the IMI-DIRECT consortium 2019, ' Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium ', Diabetologia, vol. 62, no. 9, pp. 1601-1615 . https://doi.org/10.1007/s00125-019-4906-1
Koivula, R W, Forgie, I M, Kurbasic, A, Viñuela, A, Heggie, A, Giordano, G N, Hansen, T H, Hudson, M, Koopman, A D M, Rutters, F, Siloaho, M, Allin, K H, Brage, S, Brorsson, C A, Dawed, A Y, De Masi, F, Groves, C J, Kokkola, T, Mahajan, A, Perry, M H, Rauh, S P, Ridderstråle, M, Teare, H J A, Thomas, E L, Tura, A, Vestergaard, H, White, T, Adamski, J, Bell, J D, Beulens, J W, Brunak, S, Dermitzakis, E T, Froguel, P, Frost, G, Gupta, R, Hansen, T, Hattersley, A, Jablonka, B, Kaye, J, Laakso, M, McDonald, T J, Pedersen, O, Schwenk, J M, Pavo, I, Mari, A, McCarthy, M I, Ruetten, H, Walker, M, Pearson, E, Franks, P W & IMI-DIRECT consortium 2019, ' Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes : descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium ', Diabetologia, vol. 62, no. 9, pp. 1601-1615 . https://doi.org/10.1007/s00125-019-4906-1
Diabetologia
Diabetologia, Vol. 62, No 9 (2019) pp. 1601-1615
Diabetologia, 62(9), 1601-1615. Springer Verlag
Diabetologia 62, 1601-1615 (2019)
Koivula, R W, Forgie, I M, Kurbasic, A, Viñuela, A, Heggie, A, Giordano, G N, Hansen, T H, Hudson, M, Koopman, A D M, Rutters, F, Siloaho, M, Allin, K H, Brage, S, Brorsson, C A, Dawed, A Y, De Masi, F, Groves, C J, Kokkola, T, Mahajan, A, Perry, M H, Rauh, S P, Ridderstråle, M, Teare, H J A, Thomas, E L, Tura, A, Vestergaard, H, White, T, Adamski, J, Bell, J D, Beulens, J W, Brunak, S, Dermitzakis, E T, Froguel, P, Frost, G, Gupta, R, Hansen, T, Hattersley, A, Jablonka, B, Kaye, J, Laakso, M, McDonald, T J, Pedersen, O, Schwenk, J M, Pavo, I, Mari, A, McCarthy, M I, Ruetten, H, Walker, M, Pearson, E, Franks, P W & the IMI-DIRECT consortium 2019, ' Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium ', Diabetologia, vol. 62, no. 9, pp. 1601-1615 . https://doi.org/10.1007/s00125-019-4906-1
Aims/hypothesis Here, we describe the characteristics of the Innovative Medicines Initiative (IMI) Diabetes Research on Patient Stratification (DIRECT) epidemiological cohorts at baseline and follow-up examinations (18, 36 and 48 months of follow-up)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91fc5bd3c22959b53a248befc4dd035d
https://research.vumc.nl/en/publications/5fde05e6-dbb5-4b2a-b5e2-07f7e0521b01
https://research.vumc.nl/en/publications/5fde05e6-dbb5-4b2a-b5e2-07f7e0521b01
Autor:
Philippe Froguel, Anubha Mahajan, Simone P. Rauh, Maritta Siloaho, Henrik Vestergaard, Mandy H Perry, Adem Y. Dawed, Jochen M. Schwenk, Imre Pavo, Torben Hansen, Mark Walker, Ian M Forgie, Timothy J. McDonald, Jimmy D. Bell, Anitra D.M. Koopman, E. Louise Thomas, Azra Kurbasic, Kristine H. Allin, Christopher J. Groves, Giuseppe N. Giordano, Bernd Jablonka, Ramneek Gupta, Tarja Kokkola, Andrew T. Hattersley, Femke Rutters, Caroline Brorsson, Paul W. Franks, Emmanouil T. Dermitzakis, Jerzy Adamski, Robert W. Koivula, Mark I. McCarthy, Hartmut Ruetten, Tue H. Hansen, Thomas E. White, Harriet Teare, Ana Viñuela, Michelle Hudson, Jacqueline M. Dekker, Andrea Tura, Ewan R. Pearson, Oluf Pedersen, Andrea Mari, Gary Frost, Federico De Masi, Alison Heggie, Markku Laakso, Soren Brage, Søren Brunak, Martin Ridderstråle
/SummaryBackground and aims:Understanding the aetiology, clinical presentation and prognosis of type 2 diabetes (T2D) and optimizing its treatment might be facilitated by biomarkers that help predict a person’s susceptibility to the risk factors th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad68dd6a149dc9c574098a913567b0d